Prenatal exposure to AVP or caffeine but not oxytocin alters learning in female rats

Swenson, Robyn R.; Beckwith, Bill E.; Lamberty, Kerri J.; Krebs, Scott J.; Tinius, Timothy P.

doi:10.1016/0196-9781(90)90011-s

Cited by 21 publications

(9 citation statements)

References 18 publications

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“…Prenatal caffeine exposure has also been shown to alter passive avoidance learning in a sex dependent fashion. Adult female offspring of caffeine treated dams (60 mg/kg/day on GD13–19) showed significantly enhanced retention at 25 days after training when compared to placebo treated controls [39]. Sexually dimorphic effects of prenatal caffeine exposure have also been shown on measures of locomotion and anxiety in the open field, with male animals exhibiting decreased activity and increased defecation [21].…”

Section: Discussionmentioning

confidence: 99%

Chronic prenatal caffeine exposure impairs novel object recognition and radial arm maze behaviors in adult rats

Soellner

Grandys

Nuñez

2009

Behavioural Brain Research

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In this report, we demonstrate that chronic prenatal exposure to a moderate dose of caffeine disrupts novel object recognition and radial arm maze behaviors in adult male and female rats. Pregnant dams were administered either tap water or 75 mg/L caffeinated tap water throughout gestation. Oral self-administration in the drinking water led to an approximate maternal intake of 10 mg/kg/day, equivalent to 2–3 cups of coffee/day in humans based on a metabolic body weight conversion. In adulthood, the offspring underwent testing on novel object recognition, radial arm maze, and Morris water maze tasks. Prenatal caffeine exposure was found to impair 24-hour memory retention in the novel object recognition task and impair both working and reference memory in the radial arm maze. However, prenatal caffeine exposure did not alter Morris water maze performance in either a simple water maze procedure or in an advanced water maze procedure that included reversal and working memory paradigms. These findings demonstrate that chronic oral intake of caffeine throughout gestation can alter adult cognitive behaviors in rats.

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Section: Discussionmentioning

confidence: 99%

Chronic prenatal caffeine exposure impairs novel object recognition and radial arm maze behaviors in adult rats

Soellner

Grandys

Nuñez

2009

Behavioural Brain Research

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“…Further evidence of the special significance of vasopressin relative to OT is research indicating (a) that effects of prenatal stress on social memory in rats is mediated by vasopressin 1a receptor mRNA expression but not OT receptors (Grundwald, Benítez, & Brunton, 2016) and (b) that prenatal exposure to AVP or caffeine, but not OT, alters learning in female rats (Swenson, Beckwith, Lamberty, Krebs, & Tinius, 1990). Of significance also is that whereas OT is first detected a few days following birth, AVP can be detected in the prenatal and perinatal periods in the fetal brain and is thought to play a significant role in central nervous system maturation (Bloch et al, 1990; Tribollet, Goumaz, Raggenbass, Dubois-Dauphin, & Dreifuss, 1991).…”

Section: Future Research Directionsmentioning

confidence: 99%

Prenatal programming of postnatal plasticity revisited—And extended

Hartman

Belsky

2018

Dev Psychopathol

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Two sets of evidence reviewed herein, one indicating that prenatal stress is associated with elevated behavioral and physiological dysregulation and the other that such phenotypic functioning is itself associated with heightened susceptibility to positive and negative environmental influences postnatally, raises the intriguing hypothesis first advanced by Pluess and Belsky (2011) that prenatal stress fosters, promotes, or “programs” postnatal developmental plasticity. Here we review further evidence consistent with this proposition, including new experimental research systematically manipulating both prenatal stress and postnatal rearing. Collectively this work would seem to explain why prenatal stress has so consistently been linked to problematic development: stresses encountered prenatally are likely to continue postnatally, thereby adversely affecting the development of children programmed (by prenatal stress) to be especially susceptible to environmental effects. Less investigated are the potential benefits prenatal stress may promote, due to increased plasticity, when the postnatal environment proves to be favorable. Future directions of research pertaining to potential mechanisms instantiating postnatal plasticity and moderators of such prenatal-programming effects are outlined.

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“…Although oxytocin-receptor binding was also examined as a possible mediator of such prenatal-stress effects, no evidence for such a role emerged. Further evidence of the special significance of vasopressin relative to oxytocin is research indicating (a) that effects of prenatal stress on social memory in rats is mediated by vasopressin 1a receptor mRNA expression but not oxytocin receptors (Grundwald, Benítez, & Brunton, 2016) and (b) that prenatal exposure to AVP or caffeine, but not OT, alters learning in female rats (Swenson, Beckwith, Lamberty, Krebs, & Tinius, 1990). Also of significance is that whereas OT is first detected a few days following birth, AVP can be detected in the prenatal and perinatal periods in the fetal brain, and WHAT?/UNCLEAR: OT OR AVP?…”

Section: Serotonin Although Prenatal Stress Involves a Cascade Of Comentioning

confidence: 99%

Prenatal stress and enhanced developmental plasticity

Hartman

Belsky

2018

J Neural Transm

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Two separate lines of inquiry indicate (a) that prenatal stress is associated with heightened behavioral and physiological reactivity, and (b) that these postnatal phenotypes are associated with increased susceptibility to both positive and negative developmental experiences and environmental exposures. This research considered together raises the intriguing hypothesis first advanced by Pluess and Belsky (Dev Psychopathol 23:29-38, 2011) that prenatal-stress fosters, promotes or "programs" postnatal developmental plasticity. In this paper, we review further evidence consistent with this proposition, including a novel animal study which experimentally manipulated both prenatal stress and postnatal rearing. Directions for future work focused on mechanisms mediating the plasticity-inducing effects of prenatal stress and the moderators of such effects are outlined.

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Prenatal exposure to AVP or caffeine but not oxytocin alters learning in female rats

Cited by 21 publications

References 18 publications

Chronic prenatal caffeine exposure impairs novel object recognition and radial arm maze behaviors in adult rats

Chronic prenatal caffeine exposure impairs novel object recognition and radial arm maze behaviors in adult rats

Prenatal programming of postnatal plasticity revisited—And extended

Prenatal stress and enhanced developmental plasticity

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