Prenatal exposure to bisphenol A and hyperactivity in children: a systematic review and meta-analysis

Rochester, Johanna R.; Bolden, Ashley L.; Kwiatkowski, Carol F.

doi:10.1016/j.envint.2017.12.028

Cited by 105 publications

(51 citation statements)

References 97 publications

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“…Also well documented is the capacity for developmental BPA exposure to impact non‐reproductive sexually dimorphic behaviours, especially anxiety . The available human data largely corroborate the animal data, with multiple lines of evidence linking prenatal exposure to heightened risk of deleterious childhood behaviours, including anxiety and hyperactivity …”

Section: Framing Clarity‐bpa For Brain and Behaviourmentioning

confidence: 68%

Achieving CLARITY on bisphenol A, brain and behaviour

Patisaul

2019

J Neuroendocrinology

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There is perhaps no endocrine disrupting chemical more controversial than bisphenol A (BPA). Comprising a high‐volume production chemical used in a variety of applications, BPA has been linked to a litany of adverse health‐related outcomes, including effects on brain sexual differentiation and behaviour. Risk assessors preferentially rely on classical guideline‐compliant toxicity studies over studies published by academic scientists, and have generally downplayed concerns about the potential risks that BPA poses to human health. It has been argued, however, that, because traditional toxicity studies rarely contain neural endpoints, and only a paucity of endocrine‐sensitive endpoints, they are incapable of fully evaluating harm. To address current controversies on the safety of BPA, the United States National Institute of Environmental Health Sciences, the National Toxicology Program (NTP), and the US Food and Drug Administration established the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY‐BPA). CLARITY‐BPA performed a classical regulatory‐style toxicology study (Core study) in conjunction with multiple behavioural, molecular and cellular studies conducted by academic laboratories (grantee studies) using a collaboratively devised experimental framework and the same animals and tissues. This review summarises the results from the grantee studies that focused on brain and behaviour. Evidence of altered neuroendocrine development, including age‐ and sex‐specific expression of oestrogen receptor (ER)α and ERβ, and the abrogation of brain and behavioural sexual dimorphisms, supports the conclusion that developmental BPA exposure, even at doses below what regulatory agencies regard as “safe” for humans, contribute to brain and behavioural change. The consistency and the reproducibility of the effects across CLARITY‐BPA and prior studies using the same animal strain and almost identical experimental conditions are compelling. Combined analysis of all of the data from the CLARITY‐BPA project is underway at the NTP and a final report expected in late 2019.

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Section: Framing Clarity‐bpa For Brain and Behaviourmentioning

confidence: 68%

Achieving CLARITY on bisphenol A, brain and behaviour

Patisaul

2019

J Neuroendocrinology

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“…There is some concern that fetuses, infants, toddlers, and children may be particularly vulnerable to adverse effects of BPA due to the vulnerability of developing organs to endocrine disrupting chemicals, particularly the brain, following pre- and/or postnatal exposure to BPA [ 16 ]. Indeed, early exposure to BPA has been associated with an increased risk of altered cognitive function (e.g., learning, memory) and behavior (e.g., hyperactivity), metabolic disorders (e.g., obesity), and breast or prostate cancer developed in later life [ 18 , 19 , 20 , 21 ]. In order to reduce the exposure to BPA in young children, BPA was banned in baby bottles in Canada, Europe, and USA [ 15 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Exposure to New Emerging Bisphenols Among Young Children in Switzerland

Lucarini

Krasniqi

Rosset³

et al. 2020

IJERPH

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Restrictions on the use of bisphenol A (BPA) in consumer products led to its replacement by various bisphenol (BP) analogues, yet young children’s exposure to these analogues has been poorly characterized so far. This study aimed to characterize infants’ and toddlers’ exposure to BPA and 14 emerging BP analogues (i.e., bisphenol AF, bisphenol AP, bisphenol B, bisphenol BP, bisphenol C (BPC), bisphenol E, bisphenol F (BPF), bisphenol G, bisphenol M (BPM), bisphenol P, bisphenol PH, bisphenol S (BPS), bisphenol TMC, and bisphenol Z). We extracted infants’ and toddlers’ urine from diapers (n = 109) collected in Swiss daycare centers as a practical and noninvasive alternative approach to urinary biomonitoring. Bisphenols were present in 47% of the samples, with BPC and BPM being the most frequently detected (23% and 25% of all samples, respectively). The mean concentrations of urinary BPS and BPF were greater than that of BPA. This contrasts with data reported previously. Furthermore, statistical analysis revealed a significant and negative correlation between urinary BPM concentration and the population’s age. Our results provide a first characterization of infants’ and toddlers’ exposure to bisphenols in Switzerland. This knowledge can be used to support ongoing biomonitoring studies and to prioritize exposure reduction and prevention strategies.

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“… 6 , 7 , 8 , 9 Phthalates and phenols are widely used in consumer products, including food processing and packaging equipment, personal care products (eg, cosmetics and fragrances), and pharmaceuticals, resulting in ubiquitous exposure. 6 , 10 , 11 Although epidemiologic studies have reported associations between prenatal and early childhood exposure to EDCs and ADHD-like behaviors, 8 , 12 , 13 few studies have examined the association of exposure to these chemicals during adolescence with ADHD-like behaviors. Similar to the prenatal period, adolescence is a critical time for brain development, characterized by structural and functional changes in the brain as well as the onset of behavioral problems, some of which may be due to hormonal changes.…”

Section: Introductionmentioning

confidence: 99%

Association of Exposure to Endocrine-Disrupting Chemicals During Adolescence With Attention-Deficit/Hyperactivity Disorder–Related Behaviors

et al. 2020

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Key Points Question Is exposure to endocrine-disrupting chemicals during adolescence a risk factor for behaviors associated with attention-deficit/hyperactivity disorder (ADHD)? Findings In this cross-sectional analysis of data from 205 adolescents participating in a prospective birth cohort study, exposure to select phthalates was associated with an increased risk of ADHD-related behaviors. Associations were strongest for phthalates with antiandrogenic activity. Meaning These findings support the potential importance of exposures to endocrine-disrupting chemicals, especially phthalates, during adolescence as correlates of ADHD-related behaviors.

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Prenatal exposure to bisphenol A and hyperactivity in children: a systematic review and meta-analysis

Cited by 105 publications

References 97 publications

Achieving CLARITY on bisphenol A, brain and behaviour

Achieving CLARITY on bisphenol A, brain and behaviour

Exposure to New Emerging Bisphenols Among Young Children in Switzerland

Association of Exposure to Endocrine-Disrupting Chemicals During Adolescence With Attention-Deficit/Hyperactivity Disorder–Related Behaviors

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