Prenatal exposure to chromium (Cr) and nickel (Ni) in a sample of Iranian pregnant women: urinary levels and associated socio-demographic and lifestyle factors

Moradnia, Maryam; Attar, Hossein Movahedian; Heidari, Zahra; Mohammadi, Farzaneh; Kelishadi, Roya

doi:10.1007/s11356-021-15201-w

Cited by 19 publications

(4 citation statements)

References 53 publications

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“…During the manufacturing process of cosmetic products, hexavalent chromium which is a known human carcinogen can be added as an impurity and may cause allergic dermatitis due to exposure through skin contact from such products (29). Moreover, it is also reported that the elevated levels of chromium in urinary samples of pregnant women may be associated with chromium exposure through the use of cosmetics, passive smoking, and other sources (30). Exposure to hexavalent chromium may also lead to lung cancer through inhalation and can cause an increased risk of stomach tumors due to exposure through consuming chromium contaminated drinking water (31).…”

Section: Chromiummentioning

confidence: 99%

Quantitative Analysis of Heavy Metals in Unbranded Whitening Creams Sold in Karachi

Alamgir

Fatima

Aslam

et al. 2022

Pak Euro. J. Med & LS

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The use of cosmetic products contaminated with toxic heavy metals can cause serious health issues among consumers. Especially, skin whitening products are widely used among women and consumers are completely unaware of the presence of toxic metals in such products. Therefore, the present study is conducted for the first time in Karachi that aims to assess the concentration of selected heavy metals in unbranded skin whitening creams sold in local markets of Karachi using Merck Super Nova60 kits. The findings of the study revealed that the mean concentration of heavy metals was found in the order of Pb > Cr > Ni > Cu > As among all collected samples. Proper monitoring and control of heavy metals must be required during the manufacturing process of the products to avoid serious health impacts among consumers.

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Section: Chromiummentioning

confidence: 99%

Quantitative Analysis of Heavy Metals in Unbranded Whitening Creams Sold in Karachi

Alamgir

Fatima

Aslam

et al. 2022

Pak Euro. J. Med & LS

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“…Both lifestyle and environmental factors are important risk factors for the development of cancer [ 1 , 2 ], and lifestyle determinants have been found to be significant predictors of environmental carcinogens in humans [ 3 – 5 ]. In recent years, the causal relationship between water environments and cancer epidemiology has been extensively studied on multiple scales.…”

Section: Introductionmentioning

confidence: 99%

Association between type of drinking water and upper gastrointestinal cancer incidence in the Linxian General Population

Yang

Wang

et al. 2023

BMC Cancer

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Background This study aimed to explore the association between drinking water source and risk of upper gastrointestinal (UGI) cancer, including esophageal cancer (EC) and gastric cancer (GC), in the Linxian General Population Nutrition Intervention Trial (NIT) cohort. Methods In this study, we used data from the Linxian NIT cohort, which included 29,584 healthy adults aged 40 to 69 years. Subjects were enrolled in April 1986 and followed up until March 2016. Tap water drinking status and demographic characteristics were collected at baseline. Subjects who drank tap water were treated as the exposed group. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using the Cox proportional hazard model. Results A total of 5,463 cases of UGI cancer were identified during the 30-year follow-up period. After adjusting for multiple factors, the incidence rate of UGI cancer in participants who drank tap water was significantly lower compared with individuals in the control (HR = 0.91, 95% CI: 0.86–0.97). A similar association was observed between tap water drinking and EC incidence (HR = 0.89, 95% CI: 0.82–0.97). The association between drinking tap water and risk of UGI cancer and EC incidence did not vary across the subgroup by age and gender (All Pinteraction > 0.05). For EC incidence, an interaction effect was observed for riboflavin/niacin supplements and drinking water source (Pinteraction = 0.03). No association was observed between drinking water source and GC incidence. Conclusions In this prospective cohort study in Linxian, participants who drank tap water had a lower risk of EC incidence. As a source of drinking water, use of tap water may reduce the risk of EC by avoiding exposure to nitrate/nitrite. Measures should be taken to improve the quality of drinking water in high-incidence areas of EC. Trial registration The trial is registered with ClinicalTrials.gov (NCT00342654, 21/06/2006), and the trial name is Nutrition Intervention Trials in Linxian Follow-up Study.

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“…Accumulating evidence has demonstrated that the varying degree of heavy metals exposure might exert diverse effect on sex hormone levels in diverse population and at different life stages, which renders it valuable to establish a clear and explicit relationship (14). Previous studies have demonstrated that exposure to arsenic (As), lead (Pb), chromium (Cr), nickel (Ni), urinary phthalate metabolites and phthalates during pregnancy in Iranian women may have a negative impact on the health of their children (15)(16)(17)(18). Telisman et al found a potential synergistic effect between Cd and Pb on increasing serum testosterone levels in men (19).…”

Section: Introductionmentioning

confidence: 99%

The association between blood heavy metals level and sex hormones among postmenopausal women in the US

2023

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IntroductionEnvironmental pollutants could be implicated in female endocrine setting Q6 beyond traditional factors. Until now, few study has focused on the association of environmental exposure to heavy metals with sex hormones in postmenopausal women. This study intended to investigate whether serum levels of heavy metals(i.e., Cd, Pb, Hg, Mn, Se) would influence sex hormones in postmenopausal women.Methods and resultsA cross-sectional study was performed on 614 nationally representative participants from 2013-2016 National Health and Nutrition Examination Survey (NHANES) in the US. Multivariate linear regression models and restricted cubic spline plots revealed cadmium(Cd) had linear positive association with TT(β=3.25, 95%CI= 1.12, 5.38), bioavailable TT(β=1.78, 95%CI=0.36,3.21) and TT/E2(β=0.76, 95%CI=0.28,1.24), which was more apparent in natural menopausal and obese women. Lead(Pb) had linear positive association with SHBG(β=12.84, 95%CI= 6.77,18.91), which was apparent in nearly all subgroups except in normal BMI group, and TT/E2 (β=0.69, 95%CI 0.134,1.25), which was apparent in natural menopausal and normal BMI women. Manganese(Mn) had non-linear association with SHBG, which was more apparent in natural menopausal and obese women, and TT/E2, which was more apparent in natural menopausal and normal BMI women. Selenium(Se) had U shaped non-linear association with TT, which was more apparent in hysterectomy, overweight and obese women, and SHBG, which was apparent in nearly all subgroups except in normal BMI group.ConclusionIn summary, this cross-sectional study indicates a possible role that various degree of environmental exposure to heavy metals plays in the disruption of sex Q5 hormone levels in postmenopausal women. Further experiments are needed to elucidate the underlying mechanisms.

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Prenatal exposure to chromium (Cr) and nickel (Ni) in a sample of Iranian pregnant women: urinary levels and associated socio-demographic and lifestyle factors

Cited by 19 publications

References 53 publications

Quantitative Analysis of Heavy Metals in Unbranded Whitening Creams Sold in Karachi

Quantitative Analysis of Heavy Metals in Unbranded Whitening Creams Sold in Karachi

Association between type of drinking water and upper gastrointestinal cancer incidence in the Linxian General Population

The association between blood heavy metals level and sex hormones among postmenopausal women in the US

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