Prenatal exposure to DDT in malaria endemic region following indoor residual spraying and in non-malaria coastal regions of South Africa

Channa, Kalavati; Röllin, Halina B.; Nøst, Therese Haugdahl; Odland, Jon Øyvind; Sandanger, Torkjel M.

doi:10.1016/j.scitotenv.2012.03.073

Cited by 33 publications

(32 citation statements)

References 45 publications

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“…Since the 1970s, the production and use of DDT were prohibited in many countries. The reported half-life of DDT in the environment usually ranges from 2 to 15 years (Channa et al 2012). After exposure, DDT enters the circulatory system, and it is transported via the lipid component in plasma (Turusov et al 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Besides, both p,p-DDT and its main metabolite p,p-DDE have proven to be estrogen receptor agonists and p,p-DDE an androgen receptor antagonist (Longnecker et al 1997). In addition, p,p-DDT is considered a possible human carcinogen (Channa et al 2012;Cocco et al 1997). A number of studies also showed dose-response relationships between serum concentrations of p,p-DDT and the prevalence of diabetes (Channa et al 2012;Rignell-Hydbom et al 2010).…”

Section: Discussionmentioning

confidence: 99%

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DDT and its metabolites are linked to increased risk of type 2 diabetes among Saudi adults: a cross-sectional study

Al‐Othman

Abd-Alrahman

Al-Daghri

2014

Environ Sci Pollut Res

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Organochlorine (OC) pesticides have recently been associated with type 2 diabetes in several non-Asian general populations. As there is currently an epidemic of type 2 diabetes mellitus in Asia. The prevalence and incidence of diabetes is increasing rapidly worldwide including many Arab Gulf countries. According to a community-based national epidemiological health survey, the overall prevalence of diabetes mellitus in Saudi adults (age group of 30-50 years) is 23.7%. A recent study by Al-Daghri et al. (BMC Med 9:76, 2011) reported that the prevalence of diabetes mellitus in the Kingdom of Saudi Arabia (KSA) is 31.6%. We investigated the associations between OC pesticides and type 2 diabetes in Saudi Arabia using a simple, sensitive, rapid, and selective gas chromatography coupled with mass spectrometry (GC-MS) method that has been recently developed. A total of 280 Saudi adults (136 diabetes mellitus (DM) patients and 144 non-DM controls) were randomly selected from the Riyadh Cohort Study for inclusion. The diagnosis of diabetes was based on established diagnosis and medications taken. Blood dichlorodiphenyltrichloroethane (DDT) and its derivatives were quantified using GC-MS. Residues of DDT and its derivatives were analyzed in serum by means of gas chromatography with a mass spectrometry detector. Associations between DDT exposure and T2DM were analyzed by logistic regression. DDT and its derivatives and serum concentrations of DDT and its derivative DDE showed the strongest and most significant association to type 2 diabetes in both cross-sectional and prospective studies. Associations of DDT and its derivatives varied across different diabetes-related components of the metabolic syndrome. It positively and significantly associated with four of the five of these components especially elevated triacylglycerol, high fasting glucose, high blood pressure, and HOMA-IR but negatively and significantly with HDL. Possible biological mechanisms are discussed. This study confirms previous reports relating organochlorine pesticide (OCP) exposure to diabetes and suggests possible hormonal pathways deserving further exploration. The study will be one of the first to shed light on the associations of serum levels of total DDTs and DDT derivatives among the Saudi Arab ethnicity, and diabetes type 2 chronic noncommunicable diseases are highly prevalent.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

DDT and its metabolites are linked to increased risk of type 2 diabetes among Saudi adults: a cross-sectional study

Al‐Othman

Abd-Alrahman

Al-Daghri

2014

Environ Sci Pollut Res

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“…Detection of these compounds was expected, but concentrations were at the lower end of the spectrum of those that have been previously reported in Bangladesh (Bergkvist et al 2012;Haque et al 2017;Linderholm et al 2011;Zamir et al 2009), where the highest concentrations of p,p′-DDT and p,p′-DDE have been previously found in mothers in the rural area of Matlab (median 707 and 2123 ng/g lipid, respectively) (Bergkvist et al 2012) and garment industry workers in Dhaka (2300 and 2900 ng/g lipid, respectively) (Zamir et al 2009). Cross-country comparisons highlight that concentrations in the present cohort are still lower than other countries that endorse DDT use by indoor residual spray to combat malaria, such as South Africa (2788 and 4092 ng/g lipid) (Channa et al 2012); however, they are still magnitudes higher than those observed in Europe and North America, where production and use of DDT has been eliminated through international regulations like the Stockholm Convention. For example, the median concentrations of p,p′-DDT and p,p′-DDE in breast milk from various regions of Norway were 3 and 41 ng/g lipid, respectively (Polder et al 2009), while those in North Carolina were 5 and 121 ng/g lipid, respectively (Pan et al 2010).…”

Section: Discussionmentioning

confidence: 50%

“…For comparison, the median ratio of p,p′-DDE/p,p′-DDT was 55 from recent samples in northern Norway, where DDT use has long been phased out (Nøst et al 2013); while the ratio of p,p′-DDE/p,p′-DDT ranged from 1.4 to 2.1 in malaria-endemic regions of South Africa, where the use of DDT is still encouraged for malaria control (Channa et al 2012). Recent reports have indicated that Bangladesh still has not disposed of their DDT supplies from the 1980s, where improper storage in warehouses has allowed for the contamination of the nearby environment (Illius 2016).…”

Section: Discussionmentioning

confidence: 99%

Maternal-Child Exposures to Persistent Organic Pollutants in Dhaka, Bangladesh

et al. 2018

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Information about the human burdens of persistent organic pollutants (POPs) in low-and middle-income countries is limited. In particular, studies often include only a small subset of POPs. To address this data gap, we aimed to assess maternal-child exposures to POPs in Dhaka, Bangladesh. We quantified 16 organochlorine pesticides, 12 polychlorinated biphenyls, 21 brominated flame retardants, 18 per-and polyfluorinated alkyl substances, 2 polycyclic aromatic hydrocarbons, and short-chain chlorinated paraffins in 18 pooled samples of human cord blood from 90 mother-infant pairs living in Dhaka, Bangladesh (2014. In all pooled samples, we detected high levels of p,p′-DDT (median 81.6 ng/g lipid) and its metabolites p,p′-DDE and p,p′-DDD (median 551 and 10.7 ng/g lipid, respectively), where the p,p′-DDE/p,p′-DDT ratio ranged from 2.9 to 9.8 indicating recent dichlorodiphenyltrichloroethane (DDT) exposure. We also detected acenaphthene, decabromodiphenyl ethane, o,p′-DDT, o,p′-DDE, hexachlorobenzene, β-hexachlorocyclohexane, hexabromobenzene, and perfluorooctanoic acid in a subset of samples. For the other 59 target compounds, concentrations were below the limits of detection, despite using ultra-trace analytical methodology. No trends were observed when stratifying the analyses of detected POP concentrations by maternal age, maternal body mass index, or large fish consumption. These findings highlight recent DDT exposure in Dhaka, but the overall POP burden was otherwise low in this sample of pregnant women/newborns. Future monitoring efforts should focus on newly detected POPs for which burdens may be increasing due to ongoing industrialization in Bangladesh.

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“…For instance in a study by Channa et al [49] on prenatal exposure to DDT in malaria and non-malaria regions of South Africa, DDT was equally detected among women from the non-malaria zone though at a lower concentrations than the malaria endemic regions. Again, the detection of DDT in fish especially non-resident species may not provide actual environmental pollution history.…”

Section: Ddts and Ocps In S Lalandimentioning

confidence: 99%

Polycyclic Aromatic Hydrocarbons (PAHs) and Organochlorinated Pesticides (OCPs) in Yellowtail (Seriola lalandi) from three Spatially Distinct Locations along the Coast of South Africa: Levels, Sources and Fish Size Effec

C¹,

Hoffman²,

Opara³

et al. 2017

J Food Process Technol

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Polycyclic aromatic hydrocarbons (PAHs) and organochlorinated pesticides (OCPs) such as dichlorodiphenyltrichloroethane (DDT), endosulfan and benzenhexachloride (BHC) were evaluated in yellowtail (Seriola lalandi) fish species. These hardous compounds were studied in fish sampled from three locations: Port Elizabeth, Yzerfontein and Struis Bay. The aim of the study was to investigate the profiles, levels and sources of PAHs and pesticides in yellowtail from the selected locations in relation to fish size and lipid content. Significant variations (p<0.05) were observed in the levels of PAHs measured in fish sampled from the three locations. Fish from Port Elizabeth had the highest PAHs concentrations (533.95 ± 34.36), followed by Yzerfontein (221.40 ± 33.03) and Struis Bay (88.97 ± 2.83) µg/kg wet weight. Benzo(a)pyrene (as PAHs biomarker) exceeded the recommended EU limit (2 µg/kg) in samples from Port Elizabeth and Yzerfontein whereas samples from Struis Bay did not exceed. DDT was detected only in samples from Port Elizabeth and Yzerfontein with mean total concentrations (7.48 ± 5.18 and 11.14 ± 1.44 respectively) not significantly different. Fish size (weight) correlated positively with lipid content (0.65; p<0.01) and a stronger positive correlation with ƩPAHs (0.83; p<0.01). PAHs input source in fish from Port Elizabeth reflected a mixture of petrogenic and pyrogenic whereas, Yzerfontein and Struis Bay showed input source as petrogenic. In conclusion, consumption of large sized fish in locations with high PAHs burden can predispose consumers to health risk. Further investigation into human dietary exposure with the species is recommended.

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Prenatal exposure to DDT in malaria endemic region following indoor residual spraying and in non-malaria coastal regions of South Africa

Cited by 33 publications

References 45 publications

DDT and its metabolites are linked to increased risk of type 2 diabetes among Saudi adults: a cross-sectional study

DDT and its metabolites are linked to increased risk of type 2 diabetes among Saudi adults: a cross-sectional study

Maternal-Child Exposures to Persistent Organic Pollutants in Dhaka, Bangladesh

Polycyclic Aromatic Hydrocarbons (PAHs) and Organochlorinated Pesticides (OCPs) in Yellowtail (Seriola lalandi) from three Spatially Distinct Locations along the Coast of South Africa: Levels, Sources and Fish Size Effec

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