Prenatal exposure to environmental contaminants and body composition at age 7–9 years

Adipose Tissue as a Site of Toxin Accumulation

“…Fifteen of 24 studies that investigated DDE exposures found positive associations between prenatal and early exposure to DDE and measures of obesity including BMI (189) (402) (414) (265) (189) (95) (423), weight (174) (189) (127), overweight (21, 408), rapid growth (265) (407), and waist circumference (383, 402) (101, 423). Only one 4-year study on Russian boys aged 6–8 years found a negative association between DDE and BMI (58).…”

“…Only one 4-year study on Russian boys aged 6–8 years found a negative association between DDE and BMI (58). Similar to PCBs and TCDD, there appear to be different effects between genders, as some studies found associations with obesity in females but not in males(95) (101) (408). Conversely, two studies found effects on BMI, waist circumference, and overweight and obesity at 9 years (423) and weight at 14 years (127) in males but not in females.…”

Are Environmental Contaminants Responsible for ‘Globesity’?

“…Neurotoxicity of these compounds is connected with Dopamine-based reward circuitry as well as the endocrine system, and lead to an increase of food intake and -in consequence -obesity. The problem is even more serious because some authors [95,[137][138] stated that exposure to pesticides and other environmental contaminants during the early stages of life could increase vulnerability to such substances in later life periods. According to WHO [139], as evidence grows on the fetal determinants of adult disease, the importance of promoting a healthier environment for pregnant women are recognized as priorities.…”

“…polychlorinated biphenyl 138 (PCB138); polychlorinated biphenyl 153 (PCB153); dichlorodiphenyldichloroethylene (p,p-DDE); hexachlorocyclohexane (β-HCH) cohort 298 adults PCB 138 was positively associated with BMI; HCB, p,p-DDE, and β-HCH showed quadratic associations with BMI [95] cadmium,PCBs,dioxins,p,p0-DDE and hexachlorobenzene (HCB) 114 children 7-9 years old Significant negative association was found in girls between prenatal cadmium exposure and weight, BMI and waist circumference (indicator of abdominal fat) and the sum of four skin folds (indicator of subcutaneous fat). In contrast, a significant positive association (after adjustment for confounders/covariates) was found between prenatal, p, p'-DDE exposure and waist circumference as well as waist/ height ratio in girls (indicators of abdominal fat).…”

A influência da exposição ambiental a disruptores endócrinos no crescimento e desenvolvimento de crianças e adolescentes

“…Ou seja, quanto maior a exposiç ão prenatal a cádmio, menor o IMC e o perímetro abdominal. Isto demonstra a existência de uma relaç ão entre a exposiç ão prenatal a DE e a influência tardia destes sobre a composiç ão corporal 54 .…”