Prenatal exposure to environmental pro-oxidants induces mitochondria-mediated epigenetic changes: a cross-sectional pilot study

Mishra, Pradyumna Kumar; Kumari, Roshani; Bhargava, Arpit; Bunkar, Neha; Chauhan, Prachi; Tiwari, Rajnarayan R; Shandilya, Ruchita; Srivastava, Rupesh Kumar; Singh, Radha Dutt

doi:10.1007/s11356-022-21059-3

Cited by 11 publications

(7 citation statements)

References 65 publications

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“…Though the clinical utility of ccf-NAs is being widely recognized, in-depth characterization is warranted to ensure usage in point-of-care settings. 113,114 ccf-NAs are well-known biomarkers used in prenatal diagnosis to screen for genetic abnormalities in fetuses. ccf-NAs (ccf-DNAs and cell-free noncoding RNAs) may be promising biomarkers in the diagnosis and prognosis of cancer, cardiovascular and neurological illnesses, and diabetes, according to growing data.…”

Section: Circulating Cell-free Nucleic Acids (Ccf-nas) Detection Usin...mentioning

confidence: 99%

“…Because of this, ccf-NAs are important in the pathogenesis and diagnosis of many diseases. Though the clinical utility of ccf-NAs is being widely recognized, in-depth characterization is warranted to ensure usage in point-of-care settings. , …”

Section: Circulating Cell-free Nucleic Acids (Ccf-nas) Detection Usin...mentioning

confidence: 99%

“…Though the clinical utility of ccf-NAs is being widely recognized, in-depth characterization is warranted to ensure usage in point-of-care settings. 113 , 114 …”

Section: Circulating Cell-free Nucleic Acids (Ccf-nas) Detection Usin...mentioning

confidence: 99%

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Bioanalytical Applications of Graphene Quantum Dots for Circulating Cell-Free Nucleic Acids: A Review

et al. 2022

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Graphene quantum dots (GQDs) are carbonaceous nanodots that are natural crystalline semiconductors and range from 1 to 20 nm. The broad range of applications for GQDs is based on their unique physical and chemical properties. Compared to inorganic quantum dots, GQDs possess numerous advantages, including formidable biocompatibility, low intrinsic toxicity, excellent dispensability, hydrophilicity, and surface grating, thus making them promising materials for nanophotonic applications. Owing to their unique photonic compliant properties, such as superb solubility, robust chemical inertness, large specific surface area, superabundant surface conjugation sites, superior photostability, resistance to photobleaching, and nonblinking, GQDs have emerged as a novel class of probes for the detection of biomolecules and study of their molecular interactions. Here, we present a brief overview of GQDs, their advantages over quantum dots (QDs), various synthesis procedures, and different surface conjugation chemistries for detecting cell-free circulating nucleic acids (CNAs). With the prominent rise of liquid biopsy-based approaches for real-time detection of CNAs, GQDs-based strategies might be a step toward early diagnosis, prognosis, treatment monitoring, and outcome prediction of various non-communicable diseases, including cancers.

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Section: Circulating Cell-free Nucleic Acids (Ccf-nas) Detection Usin...mentioning

confidence: 99%

Section: Circulating Cell-free Nucleic Acids (Ccf-nas) Detection Usin...mentioning

confidence: 99%

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Bioanalytical Applications of Graphene Quantum Dots for Circulating Cell-Free Nucleic Acids: A Review

et al. 2022

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“…Such perturbations within mitochondrial machinery disturb the regulatory cascade of reactive oxygen species (ROS), thereby, resulting in excessive and uncontrolled release of these reactive molecules. In addition, a growing body of evidence suggests that uncontrolled ROS could further lead to mtDNA heteroplasmy, impaired calcium homeostasis, and deficient mitophagy and subsequently increases the oxidative mtDNA damage [4, 5]. Importantly, the damage induced by ROS to mtDNA manifests as compromised production of enzymes critical for oxidative phosphorylation, further intensifying mitochondrial dysfunction and promoting increased cellular senescence [6].…”

Section: Introductionmentioning

confidence: 99%

Molecular insights into mitoepigenetic stress response signaling in age-associated cardiovascular disease risk

Soni,

Kaur,

Gurjar

et al. 2024

Preprint

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Cardiovascular diseases (CVD) represent a major challenge for the elderly population and continue to be among the leading causes of mortality worldwide. The integrity of mitochondria in peripheral lymphocytes can indicate age-related degenerative disorders, revealing the balance between bioenergetics, inflammation, and senescence. The present study aims to investigate the impact of aging on mitochondrial-mediated epigenetic stress response mechanisms in both young and elderly individuals. Mitochondrial oxidative DNA damage, repair response, copy number, methylation, fusion, fission genes, electron transport chain enzyme complex activities, pro-inflammatory cytokine levels, and associated epigenetic mechanisms were evaluated. The results demonstrate that the elderly group experienced more significant disruption in the expression of mitochondrial genes, leading to impaired mitochondrial DNA (mtDNA) integrity closely linked to mitochondrial-nuclear crosstalk, ultimately increasing their susceptibility to CVD. The findings highlight mitochondria's crucial role in cellular dynamics, influencing stress responses and epigenetic mechanisms through fusion and fission cycles. Overall, these insights provide valuable information about the complex molecular processes linking mitochondrial dysfunction to age-related cardiovascular risks, paving the way for further exploration and potential interventions in aging-related health outcomes.

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“…However, the quick realization that humans did not go extinct in the evolutionary course indicated the possible existence of less understood mechanisms of taking out unfavorable genetic garbage. [2] With the advent of more efficient, accurate, and high throughput genome sequence technologies, the precise estimate for a fraction of the genome, that is, "functional" was found to be about 10% (only). Aligning with this view, if natural selection is believed to act on each mutation independently, the resulting error load and loss in average fitness contradict the subsistence of humanity.…”

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confidence: 99%

Reproductomics: An impending driver for exposome research

Mishra¹,

Kumari²,

Shandilya³

et al. 2022

JRHM

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In our quest to recognize the role of extrinsic and intrinsic environmental factors that can profoundly affect human health, the exposome paradigm proffers an exciting avenue of research. Continuous human biomonitoring would be unfeasible because the exposome is longitudinal and dynamic. Therefore, the reproductive life course of exposome should be put together from cross-sectional snapshots at critical periods such as in utero, early childhood, adolescence, and adulthood. Of course, over the following decades, the exposome paradigm will continue to evolve in terms of its conceptual and methodologic framework. Still, our overarching goal should be to delineate underlying molecular mechanisms that promote health while preventing disease at the population level.

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Prenatal exposure to environmental pro-oxidants induces mitochondria-mediated epigenetic changes: a cross-sectional pilot study

Cited by 11 publications

References 65 publications

Bioanalytical Applications of Graphene Quantum Dots for Circulating Cell-Free Nucleic Acids: A Review

Bioanalytical Applications of Graphene Quantum Dots for Circulating Cell-Free Nucleic Acids: A Review

Molecular insights into mitoepigenetic stress response signaling in age-associated cardiovascular disease risk

Reproductomics: An impending driver for exposome research

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