Prenatal Exposure to Ketamine Leads to Anxiety-Like Behaviors and Dysfunction in Bed Nucleus of Stria Terminalis

Sun, Jing; Lin, Jianbang; Feng, Xiaolong; Lu, Zhonghua; Liu, Taian; Lin, Li; Chen, Yefei; Hu, Yuxiao; Li, Yuantao; Xu, Shiyuan; Guo, Hongbo

doi:10.1093/ijnp/pyaa002

Cited by 8 publications

(6 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Expired CO2 concentration was increased in these exposed monkeys compared to control infants. Body temperature and blood glucose were not affected by the prenatal ketamine exposure (45).…”

Section: Physiologic Effects Of Ketamine Exposurementioning

confidence: 83%

“…In humans, embryonic exposure to ketamine through pregnancy can create a great threat to brain development (45). Exposure to the neurotoxicity of ketamine has a greater effect on a developing brain than a mature adult brain (8,46,47).…”

Section: Neurobehavioral Effects Of Ketamine Exposurementioning

confidence: 99%

“…All of these regions have been directly linked to the pathophysiology of addiction (66). Furthermore, research has shown its ability to produce anxietylike symptoms (45). This is also another risk factor, as ketamine increases the vulnerability of an individual to misuse this drug.…”

Section: Ketamine Misusementioning

confidence: 99%

See 2 more Smart Citations

Effect of Prenatal Ketamine Exposure: A Focused Literature Review

Simonetti¹,

Trimble²,

Shrock³

et al. 2023

Preprint

View full text Add to dashboard Cite

Ketamine is a dissociative anesthetic and antidepressant with several biological targets. Among the many targets, ketamine, notably, has an antagonistic effect on molecular N-methyl-D-aspartate (NMDA) receptors and has been identified as a non-competitive inhibitor of these receptors. Although ketamine has a wide range of therapeutic uses in the clinical setting, it is often used recreationally due to its psychoactive and analgesic effects. Regardless of the indication, prenatal exposure to ketamine has been widely investigated. The misuse of this drug, particularly in pregnant women, has been a point of concern. The neurotoxic potential of ketamine positions it as a danger to a developing fetus. Furthermore, the ability of ketamine to cross the blood-placental barrier poses a threat to the health and maturation processes of the neonate. This paper reviewed published work that explores the mechanisms through which prenatal ketamine exposure can cause altered neurodevelopment, neurobehavior, and the physiological consequences that follow. By exploring investigations using multiple different subjects such as: rodents, non-human primates, and human subjects, this paper develops a full picture of the existing data to generate a strong foundation for improved and informed public health policies.

show abstract

“…Expired CO2 concentration was increased in these exposed monkeys compared to control infants. Body temperature and blood glucose were not affected by the prenatal ketamine exposure (45).…”

Section: Physiologic Effects Of Ketamine Exposurementioning

confidence: 83%

Section: Neurobehavioral Effects Of Ketamine Exposurementioning

confidence: 99%

See 1 more Smart Citation

Effect of Prenatal Ketamine Exposure: A Focused Literature Review

Simonetti¹,

Trimble²,

Shrock³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…It is worth noting that the anxiety effect might be mediated by various mode of actions of BuP. For example, narcotic activity is involved in parabens toxicity in invertebrates and fish (Dobbins et al, 2009) and prenatal exposure to narcotic substances causes anxiety (Sun et al, 2020). Narcosis is characterized by nonspecific disturbance of neuronal membranes integrity and functioning (Sandermann, 2008), which might persist also after the treatment ceased.…”

Section: Discussionmentioning

confidence: 99%

Behavioural effects of early‐life exposure to parabens in zebrafish larvae

Merola

Lucon‐Xiccato

Bertolucci

et al. 2021

J of Applied Toxicology

View full text Add to dashboard Cite

Parabens are classified as endocrine disrupting chemicals due to their ability to activate several nuclear receptors causing changes in hormones‐dependent signalling pathways. Central nervous system of developing organisms is particularly vulnerable to changes in hormonal pathways, which could lead to altered brain function, abnormal behaviour and even diseases later in life. The aim of the present study was to investigate the effects of exposure to butylparaben (BuP), ethylparaben (EtP) and methylparaben (MeP) during early development on nervous system using zebrafish larvae's behavioural models. Zebrafish were exposed until 4 days post fertilization (dpf) to three concentrations of each paraben chosen considering the environmentally realistic concentrations of human exposure and the benchmark‐dose lower bound calculated for zebrafish larvae (BuP: 5, 50 and 500 μg/L; EtP: 50, 500 and 5000 μg/L; MeP: 100, 1000 and 10,000 μg/L). Activity in novel and in familiar environment, thigmotaxis, visual startle response and photic synchronization of the behavioural circadian rhythms were analysed at 4, 5 and 6 dpf. Zebrafish larvae exposed to BuP 500 μg/L and EtP 5000 μg/L revealed increased anxiety‐like behaviour in novel environment. Larvae treated with 500 μg/L of BuP showed reduced activity in familiar and marginally in unfamiliar environment, and larvae exposed to 5000 μg/L of EtP exhibited hyperactivity in familiar environment. Parabens exposure did not influence the visual startle response and the photic synchronization of circadian rhythms in zebrafish larvae. This research highlighted as the exposure to parabens has the potential to interfere with behavioural development of zebrafish.

show abstract

“…The authors interpret the OFT finding as an increase in risk-taking behavior and the EPM finding as an increase in anxiety. Sun et al38 examined the effects of early exposure to ketamine in mice and found avoidance in both the central zone of an OFT and in the open arms of an EPM with combined exposure to ketamine and dexmedetomidine and Turktan et al39 reported similar findings in mice with early exposure to dexmedetomidine. Two studies that examined EPM as part of a battery of behavioral tests reported te evidence of increased anxiety resulting from isoflurane and sevoflurane exposures 40,41.…”

Section: Update On Rodent Studies Of Anesthetic-induced Developmental...mentioning

confidence: 97%

An Update on Preclinical Research in Anesthetic-Induced Developmental Neurotoxicity in Nonhuman Primate and Rodent Models

Neudecker

Thomas

et al. 2022

Journal of Neurosurgical Anesthesiology

View full text Add to dashboard Cite

T he 2022 Pediatric Anesthesia and NeuroDevelopment Assessment (PANDA) Meeting included an update on preclinical research in the field of anestheticinduced developmental neurotoxicity (AIDN), with a focus on key developments since last meeting 3 years prior. The focus was on two areas: (1) The rapid growth in reports from nonhuman primate (NHP) studies, which play a pivotal role in understanding what elements of AIDN are likely to translate to human patients; and (2) The exploration of new targets, phenotypes, and exposure paradigms that have been conducted in rodent models. The purpose of this commentary article is to summarize this discussion and expand upon it both to update the reader on key developments in AIDN research and to highlight the importance of continued animal model research. UPDATE ON NONHUMAN PRIMATE STUDIES OF AIDNThe nonhuman primate (NHP) model is of value to the field of AIDN as clinical approaches are limited due to the ethical considerations of pediatric studies. The NHP is phylogenetically close to the human condition, sharing similarities in the development and complexity of their brain, in their cognitive functions, and in behavioral repertoire. Both species show similarities in social cohabitation, and social signals in both species depend on visual cues. In contrast, small animals such as rodents strongly rely on olfactory signals. Studies exposing infant NHPs to anesthetics have greatly contributed to the field of AIDN. 1 The most recent advances, including new knowledge about structural alterations and functional outcomes induced by early-in-life anesthesia exposure and the latest findings in neuroimaging studies and investigations of underlying mechanisms and mitigating strategies, are discussed. Newly Identified Structural AlterationsEarly histopathological studies in NHPs specified the complex gyrencephalic brain and expanded the understanding of acute neurotoxic effects on the immature brain caused by the exposure to diverse anesthetics that had been described from studies in rodent pups. [2][3][4][5][6][7] As little as 3 hours exposure to isoflurane on postnatal day 6

show abstract

Prenatal Exposure to Ketamine Leads to Anxiety-Like Behaviors and Dysfunction in Bed Nucleus of Stria Terminalis

Cited by 8 publications

References 47 publications

Effect of Prenatal Ketamine Exposure: A Focused Literature Review

Effect of Prenatal Ketamine Exposure: A Focused Literature Review

Behavioural effects of early‐life exposure to parabens in zebrafish larvae

An Update on Preclinical Research in Anesthetic-Induced Developmental Neurotoxicity in Nonhuman Primate and Rodent Models

Contact Info

Product

Resources

About