Prenatal exposure to lipopolysaccharide induces changes in the circadian clock in the SCN and AA-NAT activity in the pineal gland

Spišská, Veronika; Pačesová, Dominika; Míková, Hana; Pohanová, Petra; Telenský, Petr; Novotný, Jiřı́; Bendová, Zdeňka

doi:10.1016/j.brainres.2020.146952

Cited by 6 publications

(3 citation statements)

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“…However, the developing SCN also shows adaptive flexibility to immune challenges in the early stages of development. In the same study, whereas Nr1d1 expression in the LPS-treated animal group was arrhythmic at postnatal day 3, it showed improvements, on the basis of a higher amplitude, by postnatal day 20 [88], thus suggesting the circadian clock may assist the immune system in dealing with challenges later in life.…”

Section: Circadian Rhythm Of Circadian Clock Genes In the Scnmentioning

confidence: 87%

“…As described above, the circadian cock regulates the immune system, which in turn plays a major role in the expression of circadian clock genes in the SCN. Adults with prenatal LPS exposure have elevated anxiety-like behavior along with altered rhythms of circadian clock genes in the SCN [88]: the most significant effect is on Nr1d1 expression, whereas Per2 is the least affected. However, the developing SCN also shows adaptive flexibility to immune challenges in the early stages of development.…”

Section: Circadian Rhythm Of Circadian Clock Genes In the Scnmentioning

confidence: 99%

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Circadian Regulation of Apolipoproteins in the Brain: Implications in Lipid Metabolism and Disease

Lee,

Murrell,

Chu

et al. 2023

IJMS

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The circadian rhythm is a 24 h internal clock within the body that regulates various factors, including sleep, body temperature, and hormone secretion. Circadian rhythm disruption is an important risk factor for many diseases including neurodegenerative illnesses. The central and peripheral oscillators’ circadian clock network controls the circadian rhythm in mammals. The clock genes govern the central clock in the suprachiasmatic nucleus (SCN) of the brain. One function of the circadian clock is regulating lipid metabolism. However, investigations of the circadian regulation of lipid metabolism-associated apolipoprotein genes in the brain are lacking. This review summarizes the rhythmic expression of clock genes and lipid metabolism-associated apolipoprotein genes within the SCN in Mus musculus. Nine of the twenty apolipoprotein genes identified from searching the published database (SCNseq and CircaDB) are highly expressed in the SCN. Most apolipoprotein genes (ApoE, ApoC1, apoA1, ApoH, ApoM, and Cln) show rhythmic expression in the brain in mice and thus might be regulated by the master clock. Therefore, this review summarizes studies on lipid-associated apolipoprotein genes in the SCN and other brain locations, to understand how apolipoproteins associated with perturbed cerebral lipid metabolism cause multiple brain diseases and disorders. This review describes recent advancements in research, explores current questions, and identifies directions for future research.

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Section: Circadian Rhythm Of Circadian Clock Genes In the Scnmentioning

confidence: 87%

Section: Circadian Rhythm Of Circadian Clock Genes In the Scnmentioning

confidence: 99%

Circadian Regulation of Apolipoproteins in the Brain: Implications in Lipid Metabolism and Disease

Lee,

Murrell,

Chu

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Regarding the PG, several studies have analyzed how the structure and function of this gland is impacted by cell wall components derived from both gram-negative and gram-positive bacteria ( da Silveira Cruz-Machado et al, 2010 ; da Silveira Cruz-Machado et al, 2012 ; Fernandes et al, 2017 ; Ibanez Rodriguez et al, 2018 ; Jiang-Shieh et al, 2005 ; Moravcova et al, 2021 ; Spisska et al, 2020 ; Tsai and McNulty, 1999 ). In the rat PG, and 24 h after administering either LPS from Escherichia coli (50 µg/kg) or LTA (lipoteichoic acid) from the gram-positive Staphylococcus aureus (20 mg/kg), microglial cells were found to be activated based on their immunoreactivity for CD11b (OX-42) and MHC Class II antigen (OX-6) ( Jiang-Shieh et al, 2005 ).…”

Section: Microglia Diversity Under Non-homeostatic Conditions In The...mentioning

confidence: 99%

Microglia in Circumventricular Organs: The Pineal Gland Example

Muñoz

2022

ASN Neuro

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The circumventricular organs (CVOs) are unique areas within the central nervous system. They serve as a portal for the rest of the body and, as such, lack a blood-brain barrier. Microglia are the primary resident immune cells of the brain parenchyma. Within the CVOs, microglial cells find themselves continuously challenged and stimulated by local and systemic stimuli, even under steady-state conditions. Therefore, CVO microglia in their typical state often resemble the activated microglial forms found elsewhere in the brain as they are responding to pathological conditions or other stressors. In this review, I focus on the dynamics of CVO microglia, using the pineal gland as a specific CVO example. Data related to microglia heterogeneity in both homeostatic and unhealthy environments are presented and discussed, including those recently generated by using advanced single-cell and single-nucleus technology. Finally, perspectives in the CVO microglia field are also included. Summary Statement Microglia in circumventricular organs (CVOs) continuously adapt to react differentially to the diverse challenges they face. Herein, I discuss microglia heterogeneity in CVOs, including pineal gland. Further studies are needed to better understand microglia dynamics in these unique brain areas.

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Altered circadian rhythms in a mouse model of neurodevelopmental disorders based on prenatal maternal immune activation

Delorme

Srivastava

Cermakian

2021

Brain, Behavior, and Immunity

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Prenatal exposure to lipopolysaccharide induces changes in the circadian clock in the SCN and AA-NAT activity in the pineal gland

Cited by 6 publications

References 50 publications

Circadian Regulation of Apolipoproteins in the Brain: Implications in Lipid Metabolism and Disease

Circadian Regulation of Apolipoproteins in the Brain: Implications in Lipid Metabolism and Disease

Microglia in Circumventricular Organs: The Pineal Gland Example

Altered circadian rhythms in a mouse model of neurodevelopmental disorders based on prenatal maternal immune activation

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