Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study

Tung, Pei Wen; Burt, Amber; Jackson, Brian P.; Punshon, Tracy; Lester, Barry M.; Marsit, Carmen J.

doi:10.1097/ee9.0000000000000194

Cited by 13 publications

(5 citation statements)

References 77 publications

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“…The absence of a statistically significant association between the older age of pregnant women and a higher risk of exposure to mixed heavy metal contaminations noted in the current study is not in agreement with the results from previous studies [46][47][48]. For instance, in a Chinese investigation that specifically explored the occurrence of heavy metals in different age groups, higher concentrations were found in middle-aged women when compared to younger women [64].…”

Section: Discussioncontrasting

confidence: 96%

“…The simultaneous exposure to two or three heavy metals at levels above recommended public health action levels-including mercury, manganese, and lead-has been reported before in, among others, Japan [46], the USA [47], and China [29]. In line with the results from the current study, the investigators suggested that education and low income might represent potential risk factors for exposure to multiple contaminants [46,48].…”

Section: Discussionsupporting

confidence: 88%

“…The increased risk of exposure to multiple contaminants of pregnant women from the rural areas of Suriname with two or three heavy metals might be attributable to their exposure to the noxious emissions from artisanal gold mining and agricultural activities in particularly these parts of the country [49,50]. Indeed, the consumption of fish from polluted areas represented an important risk factor for multiple heavy metal intoxications in various parts of the world [46][47][48]. Furthermore, pesticide residues and heavy metal contaminations of soil and produce have been traced back to large-scale agricultural activities in various countries, including China [51].…”

Section: Discussionmentioning

confidence: 99%

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Possible Risk Factors and Their Potential Associations with Combined Heavy Metal Exposures in Pregnant Women in the Republic of Suriname

Sewberath Misser,

Hindori-Mohangoo,

Shankar

et al. 2024

Annals of Global Health

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Background:The exposure of pregnant women to multiple environmental pollutants may be more disadvantageous to birth outcomes when compared to single-compound contaminations.Objective: This study investigated the mixed exposures to mercury, manganese, or lead in 380 pregnant Surinamese women. The factors that might be associated with the heavy metal exposures and the relative risk of the potential factors to cause the mixed exposures were explored. The influencing factors of exposures to mixed contaminants assessed were living in Suriname's rural regions, several parts of which are contaminated with heavy metals emitted from artisanal and small-scale gold mining and agricultural activities; the consumption of potentially contaminated foods; advanced maternal age; as well as a relatively low formal educational level and monthly household income.Methods: Descriptive statistics were used to calculate frequency distributions and χ2contingency analyses to calculate associations and relative risks (RR) with 95% confidence intervals (CI).Findings: Blood levels of two or three of the heavy metals above public health limits were observed in 36% of the women. These women were more often residing in the rural regions, primarily consumed potentially contaminated food items, were 35 years or older, were lower educated, and more often had a lower household income. However, only living in the rural regions (RR = 1.48; 95% CI 1.23-1.77) and a low household income (RR = 1.38; 95% CI 1.15-1.66) significantly increased the risk of exposure exceeding levels of concern to two or three of the heavy metals (by 48% and 38%, respectively). Conclusion:More comprehensive pharmacological, ecological, and epidemiological studies about exposures to mixed heavy metal contaminations in pregnant women are warranted.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Possible Risk Factors and Their Potential Associations with Combined Heavy Metal Exposures in Pregnant Women in the Republic of Suriname

Sewberath Misser,

Hindori-Mohangoo,

Shankar

et al. 2024

Annals of Global Health

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“…Authors reported some longterm deleterious effects of two neurotoxic metals (Hg and Pb) and two micronutrients (Zn and Se) on child behavior and IQ. A recent multi-element analysis performed in the US Rhode Island Child Health Study (n = 192) found a positive association (worse tests results) between increased levels of a mixture of placental metals (Cd, Co, Cu, Fe, Mn, Mo, Se and Zn) and atypical behavior in newborns (Tung et al 2022), with Cd having the largest weight in the mixture effect.…”

Section: Resultsmentioning

confidence: 99%

Prenatal metals exposure and pre-adolescents’ emotional and behavioral problems

Lozano

Broberg

Soler-Blasco

et al. 2022

ISEE Conference Abstracts

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including behaviors related to anxiety, depression, somatic complaints and withdrawal) associated with changes in eating or sleeping habits, social withdrawal, violence, drug abuse, changes in personality, and teenage suicide (Liu et al. 2011). Externalizing, or behavioral, problems (including aggressive and oppositional behaviors, inattention/hyperactivity and emotion dysregulation are outward-directed symptoms (Jaspers et al. 2012) associated with poorer educational achievement, work incapacity in young adulthood and antisocial personality disorder (Narusyte et al. 2017).The prevalence of internalizing and externalizing problems in Spanish adolescents was reported to be 22.6% and 14.6%, respectively (Ortuño-Sierra et al. 2014). Pre-and postnatal environmental exposures, including outdoor, indoor, chemical and lifestyle exposures, have been related to internalizing and behavioral problems (Maitre et al. 2021;

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“…In the second stage, we assessed the associations of air pollutant mixtures with allcause and cause-specific AECs by conducting quantile g-computation models. Quantile g-computation has been regarded as a simple and efficient statistical method for evaluating the combined effect of air pollutant mixtures when all pollutants simultaneously increase each quantile, which allows the combined air pollutants to present positive, negative, and null effects simultaneously [18,19]. In this study, we implemented this model by categorizing PM 2.5 , PM 10 , Ozone, NO 2 , and SO 2 into quantiles, coded as 0, 1, 2, 3, and 4, respectively.…”

Section: Discussionmentioning

confidence: 99%

The Combined Effects of Hourly Multi-Pollutant on the Risk of Ambulance Emergency Calls: A Seven-Year Time Series Study

Shi,

Zhou,

Zhang

et al. 2023

Toxics

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Background: Ambulance emergency calls (AECs) are seen as a more suitable metric for syndromic surveillance due to their heightened sensitivity in reflecting the health impacts of air pollutants. Limited evidence has emphasized the combined effect of hourly air pollutants on AECs. This study aims to investigate the combined effects of multipollutants (i.e., PM2.5, PM10, Ozone, NO2, and SO2) on all-cause and cause-specific AECs by using the quantile g-computation method. Methods: We used ambulance emergency dispatch data, air pollutant data, and meteorological data from between 1 January 2013 and 31 December 2019 in Shenzhen, China, to estimate the associations of hourly multipollutants with AECs. We followed a two-stage analytic protocol, including the distributed lag nonlinear model, to examine the predominant lag for each air pollutant, as well as the quantile g-computation model to determine the associations of air pollutant mixtures with all-cause and cause-specific AECs. Results: A total of 3,022,164 patients were identified during the study period in Shenzhen. We found that each interquartile range increment in the concentrations of PM2.5, PM10, Ozone, NO2, and SO2 in 0–8 h, 0–8 h, 0–48 h, 0–28 h, and 0–24 h was associated with the highest risk of AECs. Each interquartile range increase in the mixture of air pollutants was significantly associated with a 1.67% (95% CI, 0.12–3.12%) increase in the risk of all-cause AECs, a 1.81% (95% CI, 0.25–3.39%) increase in the risk of vascular AECs, a 1.77% (95% CI, 0.44–3.11%) increase in reproductive AECs, and a 2.12% (95% CI, 0.56–3.71%) increase in AECs due to injuries. Conclusions: We found combined effects of pollutant mixtures associated with an increased risk of AECs across various causes. These findings highlight the importance of targeted policies and interventions to reduce air pollution, particularly for PM, Ozone, and NO2 emissions.

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Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study

Cited by 13 publications

References 77 publications

Possible Risk Factors and Their Potential Associations with Combined Heavy Metal Exposures in Pregnant Women in the Republic of Suriname

Possible Risk Factors and Their Potential Associations with Combined Heavy Metal Exposures in Pregnant Women in the Republic of Suriname

Prenatal metals exposure and pre-adolescents’ emotional and behavioral problems

The Combined Effects of Hourly Multi-Pollutant on the Risk of Ambulance Emergency Calls: A Seven-Year Time Series Study

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