Prenatal exposure to misoprostol and congenital anomalies: Systematic review and meta-analysis

Pizzol, Tatiane da Silva Dal; Knop, Flavia Pozzobon; Mengue, Sotero Serrate

doi:10.1016/j.reprotox.2006.03.015

Cited by 95 publications

(58 citation statements)

References 15 publications

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“…Various animal studies have modeled potential biologic mechanisms behind these associations (67,111,143). Finally, survivors of labor-induced abortion using misoprostol have a higher occurrence of certain congenital anomalies, including Mobius syndrome (33). Patients with Mobius syndrome have higher-than-expected rates of autism (72), and in one recent report three out of five children with Mobius syndrome and autism had a history of in utero exposure to misoprostol (10).…”

Section: Xenobiotic Exposurementioning

confidence: 99%

The Epidemiology of Autism Spectrum Disorders

Newschaffer

Croen

Daniels

et al. 2007

Annu. Rev. Public Health

988

640

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Autism spectrum disorders (ASDs) are complex, lifelong, neurodevelopmental conditions of largely unknown cause. They are much more common than previously believed, second in frequency only to mental retardation among the serious developmental disorders. Although a heritable component has been demonstrated in ASD etiology, putative risk genes have yet to be identified. Environmental risk factors may also play a role, perhaps via complex gene-environment interactions, but no specific exposures with significant population effects are known. A number of endogenous biomarkers associated with autism risk have been investigated, and these may help identify significant biologic pathways that, in turn, will aid in the discovery of specific genes and exposures. Future epidemiologic research should focus on expanding population-based descriptive data on ASDs, exploring candidate risk factors in large well-designed studies incorporating both genetic and environmental exposure data and addressing possible etiologic heterogeneity in studies that can stratify case groups and consider alternate endophenotypes.

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Section: Xenobiotic Exposurementioning

confidence: 99%

The Epidemiology of Autism Spectrum Disorders

Newschaffer

Croen

Daniels

et al. 2007

Annu. Rev. Public Health

988

640

View full text Add to dashboard Cite

show abstract

“…There is some evidence that misoprostol is teratogenic causing an increased risk of Möbius syndrome and terminal transverse limb defects [20]; likewise fetal exposure to both mifepristone and misoprostol is also associated with Möbius syndrome [21]. Prevalence of Möbius syndrome in newborns is estimated somewhere between 1:50,000 and 1:500,000 [22].…”

Section: Discussionmentioning

confidence: 99%

A Simple Procedure for Termination of Pregnancy in the Late First Trimester with Mifeprostone and Misoprostol

Joensuu-Manninen¹,

Nissi²,

Santala³

et al. 2015

OJOG

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Purpose: To assess the efficacy of medical methods for termination of pregnancy at 9 -12 weeks of gestation. Methods: Between December 2008 and December 2010, the 116 consecutive women received 200 mg oral mifepristone and after 24 -36 hours they applied 800 µg vaginal misoprostol to medically terminate pregnancy. If the products of conception did not pass, three further doses of 400 µg misoprostol were given vaginally at three hours intervals to medically terminate pregnancy. Results: Of the 116 patients undergoing the procedure 104 (90%) aborted completely. Half of the patients aborted within 6 hours. After medical termination, five per cent of the women were treated because of infection, and five per cent needed a revisit to hospital because of excessive bleeding. Two women received a blood transfusion. Previous live births or previous inducted abortion is presented in the study results. Conclusions: Medical abortion at 9 -12 weeks' gestation is a safe alternative to surgery.

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“…Se ha reportado la asociación de onfalocele a la exposición de misoprostol durante el primer trimestre de la gestación, aunque el mecanismo por el cuál se produce el defecto de pared no ha sido explicado por ninguno de los reportes (4,14). El principal defecto asociado a la PC es el onfalocele encontrado en el 74,5% de los pacientes, defectos de esternón inferior en el 59,4%, defectos diafragmáticos en el 56,8%, defectos del pericardio en el 41,8% y las anomalías cardiacas en el 83% de los casos, siendo la comunicación interventricular la malformación mas reportada (11).…”

Section: La Primera Descripción De La Pc Fue En 1958 (8)unclassified

“…En los países donde se utiliza como abortivo sin éxito durante el primer trimestre de gestación, se han informado un espectro de malformaciones congénitas asociadas con la exposición prenatal, que incluyen el síndrome de Moebius, defectos de la pared abdominal, artrogriposis y anomalías por reducción de los miembros, entre otros (4,5,6 ). Pero no se ha asociado a la pentalogía de Cantrell (PC), la característica de este patología es el onfalocele asociado a ectopia cordis.…”

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Pentalogía De Cantrell en Un Recién Nacido Expuesto en Útero a Misoprostol

Pachajoa

2010

Rev. chil. obstet. ginecol.

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Prenatal exposure to misoprostol and congenital anomalies: Systematic review and meta-analysis

Cited by 95 publications

References 15 publications

The Epidemiology of Autism Spectrum Disorders

The Epidemiology of Autism Spectrum Disorders

A Simple Procedure for Termination of Pregnancy in the Late First Trimester with Mifeprostone and Misoprostol

Pentalogía De Cantrell en Un Recién Nacido Expuesto en Útero a Misoprostol

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