Prenatal exposure to outdoor air pollution and child behavioral problems at school age in Japan

Yorifuji, Takashi; Kashima, Saori; Diez, Midory Higa; Kado, Yoko; Sanada, Satoshi; Doi, Hiroyuki

doi:10.1016/j.envint.2016.11.016

Cited by 53 publications

(41 citation statements)

References 31 publications

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“…Nevertheless, some related studies did not find significant association between maternal exposure to NO 2 and psychomotor development (Lin et al 2014), and some studies considered it to have adverse effects on children's cognitive function (Guxens et al 2014;Porta et al 2016). And for behavior, different studies also have drawn different conclusions (Ren et al 2019;Yorifuji et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Effects of prenatal exposure to NO2 on children’s neurodevelopment: a systematic review and meta-analysis

Shang

Yang

et al. 2020

Environ Sci Pollut Res

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The neurotoxicity of NO 2 exposure is well-known and potentially causes impaired of neural functions. This review aimed to estimate associations between prenatal NO 2 exposure and neurodevelopment for children. Articles published until May 2019 reported prenatal NO 2 exposure and children's cognition, psychomotor, language, attention, IQ, and behavior function were searched according to all related terms. The main databases we retrieved included PubMed, Web of Science, Embase, and Cochrane Library. Coefficient was extracted, conversed, and synthesized by random effects meta-analysis. Meanwhile, qualitatively describe would be used for some studies which cannot be synthesized quantitatively for lack of quantity or methods inconsistency. Finally, a total of 3848 citations were searched, and only 10 studies were included. We estimated that per 10 μg/m 3 increase of NO 2 during pregnancy was associated with a − 0.76 point decrease in global psychomotor (95% CI, − 1.34, − 0.18) and a − 0.62 point decrease in fine psychomotor for children (95% CI, − 1.09, − 0.16). But no significant association found in general cognitive and language. In addition, through the literature review, it seemed that prenatal exposure to NO 2 might cause adverse impacts on children's attention, IQ, and different behaviors, but this requires confirmation from further researches. Our study indicated that prenatal exposure to NO 2 seems to be associated with impaired neural development for children, especially for fine psychomotor. However, further studies are needed for determining the effects of prenatal air pollution exposure on attention, IQ, and behavior.

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Section: Introductionmentioning

confidence: 99%

Effects of prenatal exposure to NO2 on children’s neurodevelopment: a systematic review and meta-analysis

Shang

Yang

et al. 2020

Environ Sci Pollut Res

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“…The main characteristics of the studies included in this review are summarized in Table 1 in order by date of publication. Among the 12 studies, there were 10 cohort ( [14,15,[23][24][25][26][27][28][29][30]) and two cross-sectional studies ( [31,32]). Table 2 shows the results of the eight articles with reported odds ratios.…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

“…The authors found that an increase of PM 10 exposure raised the relative risk of ADHD diagnosis. Yorifuji et al, 2017 [24] examined the effect of prenatal exposure to outdoor air pollution on child behavioural problems. A total of 39,911 children of school age were enrolled in the study, and prenatal PM exposure to outdoor air pollution was associated with behavioural problems related to attention.…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Particulate Matter Exposure and Attention-Deficit/Hyperactivity Disorder in Children: A Systematic Review of Epidemiological Studies

Donzelli

Llópis-González

Llopis-Morales

et al. 2019

IJERPH

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Attention-deficit/hyperactivity disorder (ADHD) is the most common cognitive and behavioural disorder affecting children, with a worldwide-pooled prevalence of around 5%. Exposure to particulate matter (PM) air pollution is suspected to be associated with autism spectrum disorders and recent studies have investigated the relationship between PM exposure and ADHD. In the absence of any synthesis of the relevant literature on this topic, this systematic review of epidemiological studies aimed to investigate the relationship between the exposure of children to PM and ADHD and identify gaps in our current knowledge. In December 2018, we searched the PubMed and EMBASE databases. We only included epidemiological studies carried out on children without any age limit, measuring PM exposure and health outcomes related to ADHD. We assessed the quality of the articles and the risk of bias for each included article using the Newcastle–Ottawa Scale and the Office of Health Assessment and Translation (OHAT) approach, respectively. The keyword search yielded 774 results. Twelve studies with a total number of 181,144 children met our inclusion criteria, of which 10 were prospective cohort studies and 2 were cross-sectional studies. We subsequently classified the selected articles as high or good quality studies. A total of 9 out of the 12 studies reported a positive association between PM exposure to outdoor air pollution and behavioral problems related to attention. Despite these results, we found a significant degree of heterogeneity among the study designs. Furthermore, 11 studies were judged to be at a probably high risk of bias in the exposure assessment. In conclusion, we opine that further high quality studies are still needed in order to clarify the association between PM exposure and ADHD diagnosis

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“…12,13 Previous studies suggested that exposure to air pollution during pregnancy was linked to behavioural and neuroanatomical abnormalities in the offspring, including impaired intellectual ability, reduction of brain white matter and increased risk of attention deficit/hyperactivity disorder. 1,14,15 It has also been reported that tobacco is a risk factor for congenital spinal deformities. 16 However, the molecular events underlying air pollution-associated congenital defects are still unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Air pollution exposure during pregnancy is a potential health threat to the unborn child as the pollutants might pass through placenta and affect the developing foetus . Previous studies suggested that exposure to air pollution during pregnancy was linked to behavioural and neuroanatomical abnormalities in the offspring, including impaired intellectual ability, reduction of brain white matter and increased risk of attention deficit/hyperactivity disorder . It has also been reported that tobacco is a risk factor for congenital spinal deformities .…”

Section: Introductionmentioning

confidence: 99%

Aberrantly expressed long non‐coding RNAs in air pollution‐induced congenital defects

Zheng

et al. 2019

J Cellular Molecular Medi

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Air pollution has been a serious public health issue over the past few decades particularly in developing countries. Air pollution exposure during pregnancy poses potential threat to offspring as the deleterious substances might pass through placenta to alter foetal development. A growing number of studies have demonstrated that long non‐coding RNAs (lncRNAs) participate in the development of many diseases, including congenital defects. Here, we used RNA sequencing to identify differentially expressed lncRNAs in air pollution‐exposed rat embryos compared with control group. Our data suggested that 554 lncRNAs (216 up‐regulated and 338 down‐regulated) were significantly differentially expressed in the air pollution‐exposed embryos. Moreover, potential cellular functions of these deregulated lncRNAs were predicted via KEGG signal pathway/GO enrichment analyses, which suggested the possible involvements of neurological process, sensory perception of smell and the G‐protein signalling pathway. Furthermore, potential functional network of deregulated lncRNAs and their correlated mRNAs in the development of congenital spinal abnormality was established. Our data suggested that lncRNAs may play a vital role in the pathophysiology of air pollution‐exposed congenital spinal malformation.

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Prenatal exposure to outdoor air pollution and child behavioral problems at school age in Japan

Cited by 53 publications

References 31 publications

Effects of prenatal exposure to NO2 on children’s neurodevelopment: a systematic review and meta-analysis

Effects of prenatal exposure to NO2 on children’s neurodevelopment: a systematic review and meta-analysis

Particulate Matter Exposure and Attention-Deficit/Hyperactivity Disorder in Children: A Systematic Review of Epidemiological Studies

Aberrantly expressed long non‐coding RNAs in air pollution‐induced congenital defects

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