Prenatal exposure to perfluorinated chemicals and relationship with allergies and infectious diseases in infants

Okada, Emiko; Sasaki, Seiko; Saijo, Yasuaki; Washino, Noriaki; Miyashita, Chihiro; Kobayashi, Sumitaka; Konishi, Kooichi; Ito, Yoichi M.; Ito, Rie; Nakata, Ayako; Iwasaki, Yusuke; Saito, Koichi; Nakazawa, Hiroyuki; Kishi, Reiko

doi:10.1016/j.envres.2011.10.003

Cited by 119 publications

(130 citation statements)

References 37 publications

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“…Five previous birth cohort studies have been conducted examining the adverse effects of prenatal PFAS exposure on clinical infectious or allergic disease (Fei et al 2010;Granum et al 2013;Kishi et al 2013;Okada et al 2012;Wang et al 2011). To our knowledge no previous studies have obtained information about fever as such but only about infectious diseases, as assessed by parental questionnaire or hospital diagnosis, and their findings appear to be somewhat inconsistent (Fei et al 2010;Granum et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1–4years among 359 children in the Odense Child Cohort

Dalsager

Christensen

Husby

et al. 2016

Environment International

101

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Introduction: Perfluorinated alkylated substances (PFAS) are persistent industrial chemicals that have resulted in global environmental exposures. Previous epidemiological studies have reported possible effects on the immune system after developmental PFAS exposure, but the possible impact on childhood infectious disease is unclear.Objectives: To investigate the association between prenatal exposure to PFAS and symptoms of infections at age 1-4 years. Methods:The Odense Child Cohort is an on-going prospective study on children's health, where serum concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorodecanoic acid (PFDA) and perfluorononanoic acid (PFNA) were measured in 649 pregnant women before gestational week 16. Of these women, 359 reported on symptoms of infection in their child every two weeks for a one-year period. The association between prenatal exposure to PFAS and the symptoms was estimated using a logistic regression model and a negative binomial regression model. For the latter, the outcome was reported as an incidence rate-ratio (IRR), and all models were adjusted for maternal age, educational level, parity and child age.Results: On average, and accounting for incomplete reporting, the children experienced symptoms of infection 23% of the time during one year. PFOS exposure in the high tertile compared to the low tertile was associated with a statistically significant increased proportion of days with fever (IRR: 1.65 (95% CI: 1.24, 2.18), p-trend<0.001) and an increased odds of experiencing days with fever above the median (OR: 2.35 (95%CI: 1.31, 4.11). The latter tendency was also apparent for PFOA (OR: 1.97 (95%CI: 1.07, 3.62). Further, higher concentrations of PFOS and PFOA tended to increase the number of episodes of cooccurrence of fever and coughing and fever and nasal discharge during the one-year study period. 4 Conclusion:We found a positive association between prenatal exposure to PFOS and PFOA and the prevalence of fever, which may be a sensitive marker of infection. This finding is in agreement with an immunotoxic effect of prenatal exposure to PFAS. The wider implications for childhood infectious disease deserve attention.

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Section: Discussionmentioning

confidence: 99%

Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1–4years among 359 children in the Odense Child Cohort

Dalsager

Christensen

Husby

et al. 2016

Environment International

101

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“…Furthermore, associations with immune system disorders, 11,12 endocrine disruption, 13,14 reduced fetal growth 15 and gestational diabetes 16 have been suggested in the populations with a low-level background exposure to PFASs.…”

Section: ■ Introductionmentioning

confidence: 99%

Human Exposure and Elimination Kinetics of Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs)

Shi

Vestergren

et al. 2016

Environ. Sci. Technol.

257

167

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ABSTRACT:The incomplete mass-balance of organic fluorine in human serum indicates the existence of unknown per-and polyfluoroalkyl substances (PFASs) with persistent and bioaccumulative properties. Here we characterized human exposure and elimination kinetics of chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) in metal plating workers (n = 19), high fish consumers (n = 45), and background controls (n = 8). Cl-PFESAs were detected in >98% of the sampled individuals with serum concentrations ranging <0.019−5040 ng/mL. Statistically higher median serum levels were observed in high fish consumers (93.7 ng/mL) and metal plating workers (51.5 ng/mL) compared to the background control group (4.78 ng/mL) (Kruskal−Wallis rank sum test, p < 0.01). Cl-PFESAs could account for 0.269 to 93.3% of ∑PFASs in human serum indicating that this compound class may explain a substantial fraction of previously unidentified organic fluorine in the Chinese population. Estimated half-lives for renal clearance (median 280 years; range 7.1−4230 years) and total elimination (median 15.3 years; range 10.1−56.4 years) for the eight carbon Cl-PFESA suggest that this is the most biopersistent PFAS in humans reported to date. The apparent ubiquitous distribution and slow elimination kinetics in humans underscore the need for more research and regulatory actions on Cl-PFESAs and PFAS alternatives with similar chemical structures.

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“…However, there were no significant associations between maternal PFOS and PFOA levels and food allergies, eczema, wheezing, or orotitis media in infants at the age of 18 months. 133 These new findings thus clarified the influence of PFOS and PFOA on the fetal growth stages. More detailed studies are required in the future to determine the effects of prenatal exposure to PFCs on the health outcomes for infants and children.…”

Section: Perfluorinated Chemicals Overviewmentioning

confidence: 87%

Analytical Methods for the Quantification of Bisphenol A, Alkylphenols, Phthalate Esters, and Perfluoronated Chemicals in Biological Samples

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Prenatal exposure to perfluorinated chemicals and relationship with allergies and infectious diseases in infants

Cited by 119 publications

References 37 publications

Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1–4years among 359 children in the Odense Child Cohort

Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1–4years among 359 children in the Odense Child Cohort

Human Exposure and Elimination Kinetics of Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs)

Analytical Methods for the Quantification of Bisphenol A, Alkylphenols, Phthalate Esters, and Perfluoronated Chemicals in Biological Samples

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