Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and birth outcomes: A longitudinal cohort with repeated measurements

Chen, Lin; Tong, Chuanliang; Huo, Xiaona; Zhang, Jun; Tian, Ying; Cohort, Shanghai Birth

doi:10.1016/j.chemosphere.2020.128899

Cited by 48 publications

(39 citation statements)

References 48 publications

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“…A few studies included analyses of long-chain PFAS other than PFOA or PFOS, such as PFNA, PFDA, PFUnDA, PFDoDA, PFTrDA, PFHpS, PFHxS, or Me-PFOSA-AcOH. Despite inconsistencies, the relationship between these long-chain PFAS and birth weight was mostly inverse ( 18 , 20 , 23 , 32 , 38 , 40 , 44 ), a finding which was dominant in girls ( 20 , 32 , 38 , 40 ), while other studies showed null associations ( 19 , 21 , 22 , 24 – 26 , 29 , 34 , 37 , 41 – 43 , 46 , 47 , 51 ). Meanwhile, short-chain PFAS such as PFBA, PFHpA, or PFBS were only evaluated in four studies and showed no associations with birth weight ( 20 , 26 , 29 , 44 ).…”

Section: Resultsmentioning

confidence: 94%

“…Studies that analyzed the relationship between PFAS exposures and birth weight have mostly shown inverse or null associations, although the results differed by sex, type of PFAS, and timing of exposure. Eleven studies reported inverse associations between PFOA exposure and birth weight ( 17 – 20 , 28 – 32 , 44 , 45 ), while other studies showed null associations ( 21 – 26 , 33 – 43 , 46 – 51 ). Two recent meta-analyses of 16 and 24 studies ( 69 , 70 ), found decreases in birth weight of 12.8 g ( 69 ) and 10.5 g ( 70 ) with 1 ng/ml increases in PFOA in maternal and cord blood, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Two recent meta-analyses of 16 and 24 studies ( 69 , 70 ), found decreases in birth weight of 12.8 g ( 69 ) and 10.5 g ( 70 ) with 1 ng/ml increases in PFOA in maternal and cord blood, respectively. For PFOS, 14 studies showed inverse relationships with birth weight ( 18 , 20 , 23 , 31 – 33 , 36 , 43 – 46 , 48 – 50 ), while 18 showed no associations ( 17 , 19 , 21 , 22 , 24 – 26 , 29 , 30 , 34 , 35 , 37 , 39 – 42 , 47 , 51 ). A meta-analysis of nine studies showed a 0.9 g decrease in birth weight per 1 ng/ml increases in maternal PFOS exposures ( 69 ).…”

Section: Resultsmentioning

confidence: 99%

“…Despite inconsistencies, the relationship between these long-chain PFAS and birth weight was mostly inverse (18,20,23,32,38,40,44), a finding which was dominant in girls (20,32,38,40), while other studies showed null associations (19, 21, 22, 24-26, 29, 34, 37, 41-43, 46, 47, 51). Meanwhile, short-chain PFAS such as PFBA, PFHpA, or PFBS were only evaluated in four studies and showed no associations with birth weight (20,26,29,44). Only one study assessed the effects of PFAS as mixtures using data from the Health Outcomes and Measures of Environment (HOME) study (52) and reported a small decrease in birth weight with increased exposure to a mixture of 5 PFAS (PFOA, PFNA, PFDA, PFOS, and PFHxS).…”

Section: Fetal Growthmentioning

confidence: 99%

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Early-Life Exposure to Per- and Poly-Fluorinated Alkyl Substances and Growth, Adiposity, and Puberty in Children: A Systematic Review

et al. 2021

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Per- or polyfluoroalkyl substances (PFAS), a family of synthetic polyfluorinated compounds, are widely used in consumer products. Ubiquitous exposures to PFAS, in consideration of their persistence, bioaccumulation potential, and toxicities have led to concerns regarding possible harmful effects during critical periods of development in early-life and long-term consequences on health. The potential effects of PFAS depend on various factors including the type of PFAS and the timing and level of exposure. We performed a systematic review of the epidemiologic literature to assess the effects of early-life PFAS exposure on prenatal and postnatal growth, adiposity, and puberty in children and adolescents. For birth size, most studies indicated that prenatal PFAS exposure, in particular long-chain PFAS, may impair fetal growth, albeit some reports of null associations with maternal PFAS. For growth within 2 years of age, prenatal PFAS exposure showed no associations with height and either null or negative associations with weight. However, postnatal PFAS exposures were inversely related to height and weight at 2 years in a cross-sectional study. For postnatal adiposity, prenatal PFAS may mostly have negative associations with body mass index in the first 2 years of life, but positive relationships with adiposity in childhood and adolescence, although some studies showed null associations. For puberty, the evidence for associations between early-life PFAS exposure and pubertal development or sex hormone levels were limited and inconclusive. From experimental studies, plausible mechanisms through which PFAS may affect early-life growth and puberty include PFAS-induced activation of peroxisome proliferator-activated receptor, alterations of thyroid or steroid hormone synthesis and metabolism, and their weak estrogenic or anti-androgenic properties. Although the published literature suggests possible effects of PFAS exposures on early-life growth, adiposity, and puberty, current human evidence is limited in establishing PFAS-induced effects on early-life physical development. Further investigation is warranted to clarify PFAS-induced effects on growth and physical development in consideration of the critical time-window of exposure, concomitant exposure to chemical mixtures including various PFAS types, and possible non-monotonic dose-response relationship for growth and adiposity trajectories.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Fetal Growthmentioning

confidence: 99%

See 2 more Smart Citations

Early-Life Exposure to Per- and Poly-Fluorinated Alkyl Substances and Growth, Adiposity, and Puberty in Children: A Systematic Review

et al. 2021

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“…An NHANES study looking at weight in children ages 3 -11 found no significant relationship between PFOS, PFOA, and PFNA with heightfor-age z-score (HAZ), although boys displayed significantly reduced HAZ in association with higher PFHxS [31]. In infants, it was noted that maternal exposure to PFOS, PFNA, PFDeA, PFUA and PFDoA during the first trimester was inversely associated with length of newborn female infants, but mothers' plasma collected later during gestation or post-delivery showed no significant relationships with birthweight, length, and head circumference [18]. Nonsignificant associations between maternal cord serum concentrations of PFUA, PFDeA, PFHxS, PFOS, PFOA, and PFNA with birth length have also been reported in both crude models and models adjusted for maternal age and parity [32].…”

Section: Introductionmentioning

confidence: 99%

Analysis of PFAS Levels and Associations with Adolescent Anthropometric Outcomes in NHANES

Sutherland¹,

Beau²,

Bourgeois³

et al. 2021

ODEM

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Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are found in some consumer products due to their heat resistance and durability. However, there is potential for these substances to bioaccumulate in humans. It is relevant to investigate biological effects of these chemicals, as studies have suggested early life exposure may impact human developmental outcomes such as infant birth weight and youth adiposity. The objective of the current study was to determine if a relationship exists between increasing levels of certain PFAS and anthropometrics in adolescents ages 12 -18. The three PFAS examined were: perfluorodecanoic acid (PFDeA), 2-(N-methyl-perfluoroctane sulfonamido) acetic acid (Me-PFOSA-AcOH), and perfluoroundecanoic acid (PFUA). The data was obtained from the National Health and Nutrition Examination Survey (NHANES) from the years 2011-2012 (N = 287) and 2013-2014 (N = 344). An additional analysis combined data from 3 NHANES survey cycles using sampling weights for the years 2011-2016 (N = 875) to generate a larger sample size of detectable PFAS. PFAS concentrations were classified as above or below the lower limit of detection (LLOD) to evaluate differences in weight, waist circumference, BMI (body mass index), and height using Student's t-tests. These same anthropometric outcomes were examined as continuous variables in linear regression models and were stratified by sex. In the 2013-2014 dataset, there were significant inverse associations between female concentrations of PFUA and PFDeA with waist cir-

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Effects of Maternal Environmental Exposure on Early Life Growth and Development

Wang

Tian

2023

In Utero Pediatrics

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Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and birth outcomes: A longitudinal cohort with repeated measurements

Cited by 48 publications

References 48 publications

Early-Life Exposure to Per- and Poly-Fluorinated Alkyl Substances and Growth, Adiposity, and Puberty in Children: A Systematic Review

Early-Life Exposure to Per- and Poly-Fluorinated Alkyl Substances and Growth, Adiposity, and Puberty in Children: A Systematic Review

Analysis of PFAS Levels and Associations with Adolescent Anthropometric Outcomes in NHANES

Effects of Maternal Environmental Exposure on Early Life Growth and Development

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