Prenatal Exposure to Perfluoroalkyl Substances and Body Fatness in Girls

Hartman, Terryl J.; Calafat, Antònia M.; Holmes, Adrianne K.; Marcus, Michelle; Northstone, Kate; Flanders, W. Dana; Kato, Kayoko; Taylor, Ethel

doi:10.1089/chi.2016.0126

Cited by 48 publications

(41 citation statements)

References 42 publications

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“…Studies of PFAS also report mixed results. Our observations are congruent with two studies indicating higher exposure may result in smaller size (7, 15), while others were of larger size (10, 12, 13), null (8, 11, 14, 16), or of inverted U-shaped direction (9). The Danish National Birth Cohort first identified that PFOS and PFOA may be associated with smaller infant size, particularly in boys from 0–12 months with a subsequent analysis at 7 years showing no differences in size, albeit the direction of association remains toward lower BMI (7, 8).…”

Section: Discussionsupporting

confidence: 91%

“…Hence, cross-sectional data from the NHANES Survey 2003–2004 showed that almost all pregnant women in the U.S. had quantifiable levels of these EDCs (5), raising concerns over their long-term impact on early childhood growth. The evidence of associations between prenatal exposures to PFASs and offspring obesity from ten prospective investigations has also been equivocal (7, 8, 9, 10, 11, 12, 13, 14, 15, 16). Four studies included over 1000 participants (7, 12, 14, 16).…”

Section: Introductionmentioning

confidence: 99%

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Examining Endocrine Disruptors Measured in Newborn Dried Blood Spots and Early Childhood Growth in a Prospective Cohort

Yeung

Bell

Sundaram

et al. 2018

Obesity

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Objective: To determine whether newborn concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and bisphenol A (BPA) are associated with early childhood growth. Methods: We included 1954 singletons and 966 twins from the Upstate KIDS Study (born 2008–2010) with newborn dried blood spot concentrations of PFOS, PFOA and BPA quantified by liquid chromatography tandem mass spectrometry. Children’s weight and height were reported from birth through 3 years of age. Repeated measures were modelled using generalized linear mixed models. Results: PFOS and PFOA were associated with lower BMI (−0.078 kg/m2; −0.12, −0.038 and −0.076 kg/m2; −0.17, −0.051 per 1 SD increase in log PFOS and PFOA, respectively) and not with early obesity among singletons. Inconsistent associations were observed for twins. BPA levels were higher among neonates with NICU stay (p<0.001), making associations difficult to interpret. Conclusion: Perfluorinated alkyl substances did not exhibit obesogenic associations with early measures of childhood growth. Blood-based BPA measures are limited by the non-persistent nature of the chemical and unknown sources from hospital settings may present only transient exposures.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Examining Endocrine Disruptors Measured in Newborn Dried Blood Spots and Early Childhood Growth in a Prospective Cohort

Yeung

Bell

Sundaram

et al. 2018

Obesity

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“…But most of human studies have been cross-sectional in design, and reports from longitudinal studies involved with prenatal maternal exposure are limited (Heindel et al 2015;Ranciere et al 2015). In the case of perfluoroalkyl substances (PFAS) exposure, recent studies strongly support that prenatal maternal exposure is associated with excess adiposity and obesity in childhood (Braun 2017;Braun et al 2016;Hartman et al 2017;Mora et al 2017). For example, studies from the USA found that higher prenatal perfluoroalkyl substances (PFAS) exposure was associated with a rapid increase in BMI of children between 2-8 years (Braun et al 2016), and small increases in adiposity measurements in midchildhood girls (Mora et al 2017).…”

Section: Environmental Obesogensmentioning

confidence: 99%

“…Prenatal exposures to other environmental chemicals that are possibly associated with childhood obesity include dichlorodiphenyldichloroethylene (DDE) (Tang-Peronard et al Vafeiadi et al 2015;Valvi et al 2014), hexachlorobenzene (HCB) (Vafeiadi et al 2015;Valvi et al 2014), polycyclic aromatic hydrocarbon (PAH) (Rundle et al 2012), and polybrominated diphenylethers (PBDE) (Braun et al 2016;Erkin-Cakmak et al 2015;Hartman et al 2017;Tang-Peronard et al 2014). A pooled analysis of seven European birth cohorts found that dichlorodiphenyldichloroethylene (DDE) was associated with a significant increase in weight-for-age z-score in infants (Iszatt et al 2015).…”

Section: Environmental Obesogensmentioning

confidence: 99%

Prenatal determinants of childhood obesity: a review of risk factors

Liao

Marc

et al. 2019

Can. J. Physiol. Pharmacol.

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Childhood obesity is a predictor of adult obesity and has its roots in the pre-pregnancy or pregnancy period. This review presents an overview of the prenatal risk factors for childhood obesity, which were categorized into 2 groups: biological risk factors (maternal pre-pregnancy body mass index, gestational weight gain, diabetes in pregnancy, and caesarean section), and environmental and behavioural risk factors (maternal smoking and exposure to obesogens, maternal dietary patterns, maternal intestinal microbiome and antibiotics exposure, and maternal psychosocial stress). Identifying modifiable predisposing prenatal factors for obesity will inform further development of inventions to prevent obesity over the life course, and future directions for research and intervention are discussed.

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“…Prenatal PFAS exposure, namely PFOS, was associated with smaller size at birth (weight, crown to heel length, and head circumference) [50,51], but larger size at 20 months (for PFOS) [50]. Additionally, prenatal exposure to PFOA and PFOS was associated with girls' percent total body fat at age nine within some strata of maternal education status [52]. While the previous studies have focused on prenatal exposure to PFAS and observed subtle disruptions to endocrine signaling and altered adipocyte profiles, the present study does not show the same effect with GWG among mothers.…”

Section: Discussionmentioning

confidence: 92%

Maternal serum concentrations of perfluoroalkyl substances during pregnancy and gestational weight gain: The Avon Longitudinal Study of Parents and Children

Marks

Jeddy

Flanders

et al. 2019

Reproductive Toxicology

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Perfluoroalkyl substances (PFAS) are chemicals used in the manufacture of consumer products. PFAS may act as endocrine disruptors, influencing metabolic pathways and weight-related outcomes. Previous studies observed an association between perfluorooctane sulfonic acid (PFOS) and higher gestational weight gain among under-/normal weight mothers. We analyzed associations of maternal serum pregnancy concentrations of PFAS with gestational weight gain (GWG) using data from 905 women in a subsample of the Avon Longitudinal Study of Parents and Children. Women were routinely weighed in antenatal checkups ; absolute GWG was determined by subtracting the first weight measurement from the last. Linear regression was used to explore associations of maternal PFAS concentrations with absolute GWG, stratified by prepregnancy body mass index. Associations of maternal PFOS, perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) concentrations with absolute GWG were null; 10% higher PFOS was associated with GWG of-0.03 kg (95% CI:-0.11, 0.06) among under-/normal weight mothers. Ten percent higher perfluorononanoic acid (PFNA) was associated with a higher GWG of 0.09 kg (95% CI: 0.02, 0.16) among under-/normal weight mothers. Overall, findings suggest no association between maternal PFOA, PFOS, and PFHxS concentrations and GWG, and a weak positive association between maternal PFNA and GWG. Keywords ALSPAC; endocrine disruptors; perfluoroalkyl substances; gestational weight gain; perfluorooctanoic acid (PFOA); perfluorooctane sulfonic acid (PFOS); perfluorohexane sulfonic acid (PFHxS); perfluorononanoic acid (PFNA) The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. Funding sources: The UK Medical Research Council and the Wellcome Trust (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website. This work was specifically funded by the Centers for Disease Control and Prevention (AY5350). AF is supported by a fellowship from the UK MRC (MR/M009351/1).

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Prenatal Exposure to Perfluoroalkyl Substances and Body Fatness in Girls

Abstract: General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms

Cited by 48 publications

References 42 publications

Examining Endocrine Disruptors Measured in Newborn Dried Blood Spots and Early Childhood Growth in a Prospective Cohort

Examining Endocrine Disruptors Measured in Newborn Dried Blood Spots and Early Childhood Growth in a Prospective Cohort

Prenatal determinants of childhood obesity: a review of risk factors

Maternal serum concentrations of perfluoroalkyl substances during pregnancy and gestational weight gain: The Avon Longitudinal Study of Parents and Children

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