Prenatal exposure to perfluoroalkyl substances and adipocytokines: the HOME Study

Buck, Catherine O; Eliot, Melissa; Kelsey, Karl T.; Calafat, Antònia M.; Chen, Aimin; Ehrlich, Shelley; Lanphear, Bruce P.; Braun, Joseph M.

doi:10.1038/s41390-018-0170-1

Cited by 12 publications

(9 citation statements)

References 40 publications

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“…Although some animal experiments [83] and observations in humans [84,85] found negative associations between PFAS and Leptin concentrations, often positive associations were observed. Experimental evidence for induction of higher leptin concentrations by PFAS was observed in human cells in vitro [86] and in animals [87][88][89][90] and also observations on humans showed positive associations between internal exposure to PFAS and leptin serum concentrations [91][92][93]. Specially relevant in relation to our findings concerning cognition in elderly people is the observation of Ding et al [94] who found that, in women aged 45-56, higher PFAS concentrations were associated with higher leptin and free leptin values.…”

Section: Difference In Impact Between Adolescents and Older Adultssupporting

confidence: 52%

Per- and polyfluoroalkyl substances (PFAS) and neurobehavioral function and cognition in adolescents (2010–2011) and elderly people (2014): results from the Flanders Environment and Health Studies (FLEHS)

et al. 2022

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Background PFAS are persistent, bioaccumulative compounds repelling water, oil and stains which are widely used. There is mounting evidence linking exposure to a range of adverse health outcomes including renal, hepatic, immunotoxic, reproductive, endocrine disrupting and carcinogenic effects. PFAS possibly also induce neurobehavioral and developmental effects. Within Flanders Environment and Health Studies (FLEHS) internal exposure to PFAS and relevant health effects are assessed since 2008. Results Adolescents 14–15 y (2010–2011) living in an industrially contaminated area (without known PFAS contamination) and adults 50–65 y (2014) randomly sampled from the general Flemish population using a stratified clustered multi-stage design, were recruited. For the adolescents perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were measured in serum, for the adults PFOS, PFOA, perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA) and perfluorobutane sulfonate (PFBS). In adolescents the Neurobehavioral Evaluation System (NES3) computerized battery of tests developed to study the neurological effects of an exposure to environmental agents was applied. The adults did the Stroop test, the NES3 Continuous Performance Test and the NES3 Digit Span Test. In adolescents sleepiness, masculinity and femininity were assessed via the Epworth Sleepiness Scale and Personal Attributes Questionnaires, respectively. In adolescents PFOA was associated with significantly increased somnolence, and PFOS with a significant inverse association with boys’ femininity and with girls’ masculinity. In adolescents, PFAS were also associated with a marginal decrease in sustained attention (PFOS) and cognitive performance (PFOA) and a significant decrease in short-term memory (PFOS). However, in older adults PFOS was associated with a significant increase in the capacity to pay attention and PFHxS with a significant increase in sustained attention. Conclusion Our observations point to neurobehavioral and cognitive effects of PFAS. The neurobehavioral effects might in part result from the changes in sex hormone levels that have been reported to be associated with internal exposure to PFAS. Interestingly, whereas in relation to cognition some adverse effects were recorded for adolescents, for elderly persons our observations rather suggest possible weak positive effects with respect to cognition. Our observations might be in line with the view that PFAS have many, sometimes contrasting health effects.

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Section: Difference In Impact Between Adolescents and Older Adultssupporting

confidence: 52%

Per- and polyfluoroalkyl substances (PFAS) and neurobehavioral function and cognition in adolescents (2010–2011) and elderly people (2014): results from the Flanders Environment and Health Studies (FLEHS)

et al. 2022

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“…Previous studies on adipokine hormones at birth primarily focused on leptin and adiponectin, and somewhat mixed results have been reported. In the HOME study of 230 mother-infant pairs, no associations were seen between the 2nd trimester serum-PFAS concentrations (i.e., PFOA, PFOS, PFHxS, and PFNA) and cord blood leptin and adiponectin ( Buck et al, 2018 ). When stratifying by sex, PFNA was associated with increased leptin in males but decreased leptin in females.…”

Section: Discussionmentioning

confidence: 96%

“…Potential confounders were selected and included in the regression model if they had been associated with prenatal and childhood PFAS concentrations and metabolic functions in prior literature (directed acyclic graphs are included as Figure S1 and S2 ) ( Braun et al, 2016 ; Buck et al, 2018 ; Domazet et al, 2020 ; Fleisch et al, 2017 ; Halldorsson et al, 2012 ; Hoyer et al, 2015 ; Karlsen et al, 2017 ; Mora et al, 2017 ; Shelly et al, 2019 ). We included maternal education and child sex in all models.…”

Section: Methodsmentioning

confidence: 99%

“…Further, there is increasing evidence connecting metabolism, inflammatory, and autoimmune diseases to resistin, an adipocyte-specific hormone ( Jamaluddin et al, 2012 ; Tripathi et al, 2020 ). However, few previous studies have examined the association between PFAS exposure and serum concentrations of adipokine hormones in children, and the majority of these studies focused on leptin and adiponectin only and reported inconsistent results ( Ashley-Martin et al, 2017 ; Buck et al, 2018 ; Domazet et al, 2020 ; Fleisch et al, 2017 ; Minatoya et al, 2017 ; Shelly et al, 2019 ). Only two previous studies considering longitudinal effects of PFAS exposure ( Fleisch et al, 2017 ; Shelly et al, 2019 ), and none of them implemented mixture methods to estimate the overall effect of exposures to PFAS mixtures.…”

Section: Introductionmentioning

confidence: 99%

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Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort

Shih

Blomberg

Jørgensen

et al. 2022

Environmental Research

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“… 11 , 12 These hormonal factors include leptin and its receptor, adiponectin, and resistin, which are associated with childhood growth and with the odds of being or becoming overweight and developing chronic disease. 12 – 14 Serum-adipokine concentrations may be affected by other factors, e.g., preterm birth that appears to be associated with lower adiponectin and higher leptin and resistin in later childhood. 14 , 15 In addition, the duration of breastfeeding may be of potential importance, as the presence of adipokines has been detected in human milk.…”

Section: Introductionmentioning

confidence: 99%

Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood

et al. 2023

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Background Perfluoroalkyl substances (PFASs) are transferred through human milk and may cause elevated exposure during infancy. Given the lack of early postnatal blood samples, PFAS concentrations can be estimated to serve as predictors of subsequent metabolic toxicity. Methods A total of 298 children from a prospective birth cohort were followed up through to age 9 years. Serum-PFAS was measured at birth and 18 months of age, while exposures during infancy were estimated by structural equations. Adiponectin, resistin, leptin, and the leptin receptor were measured in serum at age 9. Adjusted regression coefficients for estimated serum-PFAS concentrations were calculated, with additional consideration of the duration of breastfeeding and potential effect modification by sex. Results A doubling in estimated serum-PFAS concentrations, particularly at ages 6 and 12 months, was associated with a loss of about 10–15% in age 9 resistin concentrations, while other associations were much weaker. Sex dependence of the associations was not observed, and neither did the duration of breastfeeding affect outcomes at age 9. Conclusion Lowered serum-resistin concentrations at age 9 years were most strongly associated with early postnatal PFAS exposures. These findings suggest that infancy may represent a vulnerable time window for some aspects of metabolic programming that may be affected by PFAS exposure. Impact Serum-PFAS concentrations during infancy can be estimated in the absence of blood samples. Adipokine concentrations were measured at age 9 years as metabolic biomarkers. Resistin was significantly lower in children with elevated PFAS exposures in infancy. The findings suggest that early postnatal PFAS exposures may affect subsequent metabolic health. Assessment of infancy vulnerability to PFAS can be explored using estimated serum-PFAS concentrations.

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Prenatal exposure to perfluoroalkyl substances and adipocytokines: the HOME Study

Cited by 12 publications

References 40 publications

Per- and polyfluoroalkyl substances (PFAS) and neurobehavioral function and cognition in adolescents (2010–2011) and elderly people (2014): results from the Flanders Environment and Health Studies (FLEHS)

Per- and polyfluoroalkyl substances (PFAS) and neurobehavioral function and cognition in adolescents (2010–2011) and elderly people (2014): results from the Flanders Environment and Health Studies (FLEHS)

Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort

Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood

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