2015
DOI: 10.4172/0974-8369.1000236
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Prenatal Exposures to Environmental Agents or Drugs Promote the Development of Diseases Later in Life

Abstract: Prenatal or early postnatal exposure to several agents displaying hormonal action causes persistent quantitative and qualitative changes in hormone receptors in various cell-types. Exposure must occur during the windows of susceptibility, which occurs at specific times for each cell-type and hormone receptor. These alterations, that persist through life, are induced by the mechanism of epigenetic imprinting (cell programming). Studies performed in our Labs and elsewhere found that not only hormones or agents d… Show more

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Cited by 3 publications
(3 citation statements)
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“…For example, following chronic exposure of 30 or more years to As, the probability of mortality increases dramatically due to lung and bladder cancers. In addition, prenatal or infant exposure to low levels of these elements, through the mechanism of epigenetic imprinting, can cause irreversible biochemical changes that promote the development of various organic diseases or neurobehavioral alterations in later years ( Tchernitchin et al, 2013 ; Tchernitchin & Gaete, 2015 ). Also, the prenatal exposure to As increases the probability of mortality due to bronchiectasis between the ages of 30–49 years ( Smith & Steinmaus, 2009 ); prenatal or infant exposure to Pb affects reproductive functions, decreases intelligence, and causes serious neurobehavioral changes in later stages of life ( Tchernitchin et al, 2013 ).…”
Section: Discussionmentioning
confidence: 99%
“…For example, following chronic exposure of 30 or more years to As, the probability of mortality increases dramatically due to lung and bladder cancers. In addition, prenatal or infant exposure to low levels of these elements, through the mechanism of epigenetic imprinting, can cause irreversible biochemical changes that promote the development of various organic diseases or neurobehavioral alterations in later years ( Tchernitchin et al, 2013 ; Tchernitchin & Gaete, 2015 ). Also, the prenatal exposure to As increases the probability of mortality due to bronchiectasis between the ages of 30–49 years ( Smith & Steinmaus, 2009 ); prenatal or infant exposure to Pb affects reproductive functions, decreases intelligence, and causes serious neurobehavioral changes in later stages of life ( Tchernitchin et al, 2013 ).…”
Section: Discussionmentioning
confidence: 99%
“…Prenatal and early postnatal exposure to environmental factors primarily associated with the mother and including early-life stress, maternal care, and nutrition, taking pharmaceutical drugs or medication can exert adverse effects on offspring and promote the development of different diseases later in life ( Tchernitchin and Gaete, 2015 ). These early environmental factors that affect an organism's phenotype result from gene-environment interactions, which are mediated by epigenetic modifications of the genome.…”
Section: The Impact Of the Environment On The Development Of The Adul...mentioning
confidence: 99%
“…Further, although not directly related with climate change but related to massive migrations and social turbulences, the effects of prenatal and early infant exposure to agents such as polycyclic aromatic hydrocarbons, benzopyrene, dioxins and polychlorobiphenyls should be investigated, especially since this early exposure favors the development of organic diseases and neurobehavioral changes [5]. Results of recent investigations of delayed effects of early exposure to such environmental agents, together results that may be obtained in future investigations, should alert countries governments to endorse stricter standards and tighten legislation to protect future generations from diseases that may develop following prenatal or early infant exposures [6].…”
Section: Am J Biomed Sci and Resmentioning
confidence: 99%