Prenatal high-dose pyridoxine may prevent hypertension and syndrome X in-utero by protecting the fetus from excess glucocorticoid activity

McCarty, Mark F.

doi:10.1054/mehy.1999.0956

Cited by 4 publications

(2 citation statements)

References 59 publications

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“…However, there are animal studies suggesting that ANS treatment may also cause permanent changes in kidney morphology and renal function. 29,30 Exposure of the fetus to higher levels of glucocorticoids has been associated with intrauterine growth restriction, 31 which in turn has been suggested to increase susceptibility to hypertension and cardiovascular diseases during adult life both in human and animal studies. 32,33 Whether ANS plays a role in long-term renal function needs to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Antenatal Steroids and Acute Kidney Injury in Preterm Infants

2021

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Objective The aim of this study was to identify the effects of antenatal steroids (ANS) on acute kidney injury (AKI) in very low birth weight (VLBW) preterm infants. Study Design We performed a retrospective cohort study of VLBW infants admitted to a tertiary-care neonatal intensive care unit between January 2016 and June 2019. Infants were divided into no ANS, partial ANS, and complete ANS groups. Serum creatinine (SCr) levels and rates of AKI during the first 2 weeks of life were compared. Results During the study period, 335 infants met our inclusion criteria. Among no, partial, and complete ANS groups, there were significant differences in rates of stages 2 and 3 AKI (17, 11, and 6%, respectively). Logistic regression analysis revealed that complete ANS course was associated with lower rates of AKI (odds ratio [OR] = 0.41 95% confidence interval [CI]: 0.20–0.83) and stages 2 and 3 AKI (OR = 0.205 95% CI: 0.075–0.563) compared with no ANS. Infants in complete ANS group had significantly lower SCr at 72 hours of life and at discharge, SCr peak was compared with infants in no ANS group. Conclusion In VLBW infants, complete ANS exposure may be associated with improved renal function and decreased risk for AKI compared with no ANS. Key Points

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Section: Discussionmentioning

confidence: 99%

Antenatal Steroids and Acute Kidney Injury in Preterm Infants

2021

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“…Vitamin B6 deficiency is associated with miscarriage, preeclampsia, gestational carbohydrate intolerance, hyperemesis gravidarum, and neurological diseases in infants [157]. Supplementation with vitamin B6 has been shown to reduce the chance of miscarriage by 50% and to prevent stress from affecting fetal growth [164,165]. Vitamin B6 has also been indicated to improve insulin resistance and to reduce oxidative DNA damage and C-reactive protein, and it may act similarly on progesterone and reduce prolactin in order to prevent miscarriage [166,167].…”

Section: Vitamin Supplementsmentioning

confidence: 99%

Complementary and Alternative Medicine for Threatened Miscarriage: Advantages and Risks

Zhou

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Threatened miscarriage is one of the most common complications causing pregnancy loss, and it affects approximately 20% of confirmed pregnancies. More and more women are seeking treatment with complementary and alternative medicine (CAM) for this common complication, and it has been reported that women have had successful pregnancies after threatened miscarriage when being treated with CAM, which mainly includes Chinese herbal medicines, acupuncture, and nutritional supplements as well as psychological interventions and other approaches. However, many experts are concerned about the safety and adverse events of certain CAM approaches in women with threatened miscarriage. Therefore, this review focuses on the status of CAM for threatened miscarriage and presents the potential therapeutic efficacy and safety of CAM based on some clinical and experimental studies. We thus hope to provide some instructive suggestions for the application of CAM for treating threatened miscarriage in the future.

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