Prenatal high salt programs enhanced sympathoadrenal activation of the cardiovascular response to restraint

Porter, James P.; King, Summer H.

doi:10.1016/j.autneu.2009.04.006

Cited by 5 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, the diversity of maternal interventions which affect abnormalities in this pathway implies a high degree of developmental plasticity and vulnerability in the relevant neuronal circuitry [21]. In rats, prenatal stress [22], hypoxia [23] and glucocorticoid exposure [24], malnutrition [25], salt-loading [26] and maternal obesity [8] all increase pressor responsiveness to an acute stress in adult offspring. Prenatal glucocorticoid exposure may also play a role in a model of maternal fat feeding as we have previously reported two-fold increase in corticosterone in plasma of high-fat fed dams (day 20 of gestation) compared to controls [27].…”

Section: Discussionmentioning

confidence: 99%

Increased Cardiovascular Reactivity to Acute Stress and Salt-Loading in Adult Male Offspring of Fat Fed Non-Obese Rats

Rudyk¹,

Makra

Jansen

et al. 2011

PLoS ONE

View full text Add to dashboard Cite

Diet-induced obesity in rat pregnancy has been shown previously to be associated with consistently raised blood pressure in the offspring, attributed to sympathetic over-activation, but the relative contributions to this phenotype of maternal obesity versus raised dietary fat is unknown. Sprague-Dawley female rats were fed either a control (4.3% fat, n = 11) or lard-enriched (23.6% fat, n = 16) chow 10 days prior to mating, throughout pregnancy and lactation. In conscious adult (9-month-old) offspring cardiovascular parameters were measured (radiotelemetry). The short period of fat-feeding did not increase maternal weight versus controls and the baseline blood pressure was similar in offspring of fat fed dams (OF) and controls (OC). However, adult male OF showed heightened cardiovascular reactivity to acute restraint stress (p<0.01; Δ systolic blood pressure (SBP) and Δheart rate (HR)) with a prolonged recovery time compared to male OC. α1/β-adrenergic receptor blockade normalised the response. Also, after dietary salt-loading (8%-NaCl ad libitum for 1 week) male OF demonstrated higher SBP (p<0.05) in the awake phase (night-time) and increased low/high frequency ratio of power spectral density of HR variability versus OC. Baroreflex gain and basal power spectral density components of the heart rate or blood pressure were similar in male OF and OC. Minor abnormalities were evident in female OF. Fat feeding in the absence of maternal obesity in pregnant rats leads to altered sympathetic control of cardiovascular function in adult male offspring, and hypertension in response to stressor stimuli.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased Cardiovascular Reactivity to Acute Stress and Salt-Loading in Adult Male Offspring of Fat Fed Non-Obese Rats

Rudyk¹,

Makra

Jansen

et al. 2011

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Данное несоответствие указывает, что на развитие АГ влияет не количество нефронов, а, скорее всего, время и среда, в которой возни кает дефицит нефронов [22]. Потребление продуктов с повышенным количеством соли во время беременности может вызвать гиперре активность почек на стресс, и даже при отсутствии какого либо дефицита нефронов повышается вероятность развития АГ в более позднем возрасте, не исключая вовлечение и активацию симпато надпочечниковой систе мы [29]. Ограничение потребление белка, осо бенно в последнем триместре беременности, когда происходит интенсивный нефрогенез, приводит к сокращению на 20-30% количества нефронов и к последующему развитию АГ.…”

Section: св кожокарь нг мэтрэгунэ ли бикир тхорякunclassified

Perinatal Programming of Hypertension and Obesity in Children

Cojocar¹,

Metregune²,

Bikir-Tkhoryak³

2019

MPU

View full text Add to dashboard Cite

На сегодня накоплены многочисленные данные о влиянии перинатальных факторов риска на развитие артериальной гипертензии (АГ) и ожирения у детей. Выявление и устранение этих факторов дает возможность предотвращения АГ и ожирения у детей. Цель: определение роли перинатальных факторов риска на развитие АГ и ожирения у детей в возрасте 10-18 лет. Материалы и методы. В исследовании приняли участие 218 детей с избыточным весом/ожирением в возрасте 10-18 лет, которые были разделены на две группы в соответствии с параметрами артериального давления: I группа-108 детей с АГ, II группа-110 детей с нормальным артериальным давлением. Для выявления перинатальных факторов риска проводили анкетирование матерей.

show abstract

Posttraumatic Stress Disorder Disturbs Coronary Tone and Its Regulatory Mechanisms

et al. 2017

View full text Add to dashboard Cite

Posttraumatic stress disorder (PTSD) is associated with myocardial injury, but changes in coronary regulatory mechanisms in PTSD have not been investigated. This study evaluated the effect of PTSD-inducing stress on coronary tone and its regulation by nitric oxide (NO) and voltage-gated K channels. PTSD was induced by exposing rats to predator stress, 15 min daily for 10 days, followed by 14 stress-free days. Presence of PTSD was confirmed by the elevated plus-maze test. Coronary tone was evaluated from changes in coronary perfusion pressure of Langendorff isolated hearts. Predator stress induced significant decreases in coronary tone of isolated hearts and in blood pressure of intact rats. L-NAME, a non-selective NO synthase (NOS) inhibitor, but not S-MT, a selective iNOS inhibitor, and increased coronary tone of control rats. In PTSD rats, both L-NAME and S-MT increased coronary tone. Therefore, the stress-induced coronary vasodilation resulted from NO overproduction by both iNOS and eNOS. NOS induction was apparently due to systemic inflammation as evidenced by increased serum interleukin-1β and C-reactive protein in PTSD rats. Decreased corticosterone in PTSD rats may have contributed to inflammation and its effect on coronary tone. PTSD was also associated with voltage-gated K channel dysfunction, which would have also reduced coronary tone.

show abstract

Prenatal high salt programs enhanced sympathoadrenal activation of the cardiovascular response to restraint

Cited by 5 publications

References 16 publications

Increased Cardiovascular Reactivity to Acute Stress and Salt-Loading in Adult Male Offspring of Fat Fed Non-Obese Rats

Increased Cardiovascular Reactivity to Acute Stress and Salt-Loading in Adult Male Offspring of Fat Fed Non-Obese Rats

Perinatal Programming of Hypertension and Obesity in Children

Posttraumatic Stress Disorder Disturbs Coronary Tone and Its Regulatory Mechanisms

Contact Info

Product

Resources

About