2008
DOI: 10.1001/archgenpsychiatry.2007.47
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Prenatal Hormone Exposure and Risk for Eating Disorders

Abstract: The masculinization of DE in OS female twins is unlikely to be due to socialization effects alone. Biological factors, such as the masculinization of the central nervous system by prenatal testosterone exposure, may also contribute to sex differences in DE prevalence.

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Cited by 108 publications
(94 citation statements)
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References 53 publications
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“…23 Importantly, NT exposure in female rats increases visceral adiposity distribution in adults 24,25 and this is true in mice, as noted above. 6 Second, in humans, females from opposite sex twin pairs exposed to prenatal testosterone from testes of a male co-twin develop masculinized eating behaviors as adults, 26 a finding we observed in our mice. 8 Thus, perinatal, transient, and moderate androgen excess in female humans, primates, and rodents reprograms their genetic predisposition to obesity and MEtS in adulthood in a similar manner.…”
supporting
confidence: 70%
“…23 Importantly, NT exposure in female rats increases visceral adiposity distribution in adults 24,25 and this is true in mice, as noted above. 6 Second, in humans, females from opposite sex twin pairs exposed to prenatal testosterone from testes of a male co-twin develop masculinized eating behaviors as adults, 26 a finding we observed in our mice. 8 Thus, perinatal, transient, and moderate androgen excess in female humans, primates, and rodents reprograms their genetic predisposition to obesity and MEtS in adulthood in a similar manner.…”
supporting
confidence: 70%
“…Non significant paths (based on 95% confidence intervals) are denoted by a dashed path females from same-sex pairs, and, reciprocally, males from opposite-sex pairs had a higher mean for ART than males from same-sex pairs, suggesting an intriguing twin dynamic in opposite sex pairs. Such a relationship has been attributed to biological (prenatal androgenisation) and/or social factors (cross-sex socialisation) (Culbert et al 2008;Loehlin and Martin 2000;Rose et al 2002). However, closer inspection revealed that this difference between oppositesex and same sex pairs was found only in the 17 and over age group.…”
Section: Discussionmentioning
confidence: 99%
“…The participants completed in-person assessments privately in individual computer rooms in the laboratory. Regardless of the recruitment methods used, the twins in the current study have been found to be broadly representative of women in Michigan in terms of racial identification (Culbert et al 2008).…”
Section: Participantsmentioning
confidence: 95%