Prenatal induction of sucrase activity in rat jejunum

Celano, Paul; Jumawan, Jocelyn; Horowitz, Carolyn; Lau, Herbert; Koldovský, Otakar

doi:10.1042/bj1620469

Cited by 45 publications

(21 citation statements)

References 17 publications

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“…Not only the goblet cells [2] but also the other enterocytes [3] on the villi in the spiny mouse are vacuolar, possibly due to the presence of the glycogen [8]. At the basis of the villi, the morphology of the epithelium indicates the areas where the crypts [4] will form. In the spiny mouse, epithelial invaginations that will produce Lieberkuhn's crypts, can already be discerned [5].…”

Section: Resultsmentioning

confidence: 99%

“…The absence of an effect of any of the hormones tried on sucrase activity immediately after birth in the spiny mouse is remarkable for several reasons. Firstly, Koldovsky and co-workers [3,4,17] have shown that sucrase activity in the rat is inducible by glucocorticosteroid and thyroid hormones in the perinatal period. Secondly, although glucocorticosteroid hormone levels in the spiny mouse are low, thyroid hormone levels show a surge immediately after birth [Lamers et al, in preparation], so that a synergistic effect on sucrase activity would be expected.…”

Section: Discussionmentioning

confidence: 99%

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Perinatal Development of the Small Intestine and Pancreas in Rat and Spiny Mouse

1985

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Rat (Raitus norvegicus)and spiny mouse (Acomys cahirinus)are closely related species that mainly differ in the developmental timing of birth. A comparison between the developmental profiles of some characteristic enzymes of the small intestine (lactase and sucrase) and of the pancreas (amylase) of both species was carried out to elucidate the question to what extent these enzymic profiles and hence the maturation of these organs was related to the process of birth. It was found that these organ-specific enzymes become first detectable at the same developmental stage in both species. Likewise, the weaning phase of the enzymic profiles occurred at the same developmental time point in both species. It is argued that both the first appearance and the weaning increase in enzyme activity follow an inherent biological program that can only be modulated by hormones. In contrast, the perinatal phase of the enzymic profile is completely dependent on the developmental timing of birth, and therefore appears not to be anchored to a particular developmental time point but rather to be dependent on birth-associated (hormonal) adaptation. In accordance with this hypothesis it was found that the development of the microscopic anatomy of the small intestine proceeded independently of the functional adaptation of the intestine to the process of birth.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Perinatal Development of the Small Intestine and Pancreas in Rat and Spiny Mouse

1985

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“…The administration of thyroxine or cor tisone to undernourished rats during the 3rd week of postnatal development stimulated the sucrase and alkaline phosphatase activi ties (3-to 6-fold) while lactase activity was significantly reduced under these conditions. The role of thyroxine and corticosteroids in the regulation of sucrase activity has been well documented in experimental animals [5], Adrenalectomy or thyroidectomy results in a delay in the appearance of sucrase activ ity in rats [15,16]. During early postnatal life, lactase activity is maximum and it falls con siderably at the end of the 3rd week of post natal life when sucrase activity begins to ap pear and gradually increases to a constant level [22], The development of alkaline phos phatase is also reported to be affected with steroids [20].…”

Section: Discussionmentioning

confidence: 99%

“…Thyroxine and corticosteroids are well known to be implicated in the process of cell maturation [26], Celano et al [5] dem onstrated that thyroxine or cortisone ad ministration to rats induces precocious ap pearance of sucrase in the intestine. Altera tions in intestinal function with the devel opment of the tissue have also been re ported [23,25], In a previous report from this laboratory, we demonstrated that im position of undemutrition during suckling markedly altered the structural and func tional activities of the epithelial cells, which is presumably due to 'delayed' tissue matu ration [19].…”

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confidence: 99%

Alterations in Intestinal Function in Response to Thyroxine and Cortisone Administration in Undernourished Rats

Pathak¹,

Dudeja²,

Ansari³

et al. 1982

Ann Nutr Metab

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Imposition of undernutrition during the suckling period considerably enhanced the intestinal uptake of D-glucose and glycine compared to a control group. Brush border sucrase, and alkaline phosphatase activities were drastically reduced while lactase and leucine amino peptidase levels were significantly elevated at weaning in nutritionally deprived pups as compared to control animals. Cortisone administration to undernourished rats depressed the uptake of D-glucose but stimulated that of glycine. Thyroxine treatment to undernourished animals reduced the uptake of glucose but had no effect on glycine absorption. Brush border sucrase and alkaline phosphatase activities were stimulated in cortisone- or thyroxine-injected undernourished rats but lactase activity was depressed under these conditions. Leucine aminopeptidase activity remained unaffected in cortisone- or thyroxine-administered undernourished pups.

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“…Hyperactivity of adrenals [5] and hypoinsulinism [4] have been observed in scurvy. Recently Celano et al [10] have demonstrated that administra tion of cortisone or triiodothyronine can elicit precocious development of sucrase ac tivity in the intestine of rats. Brush border disaccharidases are also stimulated in dia betes [21], a metabolic disorder resulting from the lack of insulin in the body.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin C Deficiency in Guinea Pigs on Intestinal Functions and Chemical Composition of Brush Border Membrane

et al. 1981

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The effect of vitamin C deficiency on the digestive and absorptive functions of the gut has been investigated in guinea pigs. The absorption of D-glucose was significantly elevated, but that of L-leucine, L-alanine and L-lysine considerably depressed in the intestine of scorbutic guinea pigs compared to controls. The intestinal transport of vitamin B₁₂ was also diminished. Activities of sucrase and alkaline phosphatase on the brush border were enhanced, but that of leucine aminopeptidase markedly reduced in scorbutic animals compared to controls. Maltase activity was unaffected in vitamin C deficient animals. Chemical analysis of the brush borders isolated from scorbutic animals revealed a considerable decrease in membrane protein, total lipids, phospholipids, and free cholesterol contents compared to control animals. In vivo 2-¹⁴C-acetate incorporation into membrane lipids suggested that the observed decrease in lipid components of the scorbutic membranes is due to reduced synthesis. Administration of ascorbic acid to scorbutic animals ameliorated the intestinal aberrations observed in scurvy.

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Prenatal induction of sucrase activity in rat jejunum

Abstract: Daily application of cortisone acetate (10mg/100g body wt.) or L-tri-iodothyronine (20 microng/100g body wt.) to female rats in the last (third) week of pregnancy elicits a precocious appearance of jejunal sucrase in their foetuses.

Cited by 45 publications

References 17 publications

Perinatal Development of the Small Intestine and Pancreas in Rat and Spiny Mouse

Perinatal Development of the Small Intestine and Pancreas in Rat and Spiny Mouse

Alterations in Intestinal Function in Response to Thyroxine and Cortisone Administration in Undernourished Rats

Effect of Vitamin C Deficiency in Guinea Pigs on Intestinal Functions and Chemical Composition of Brush Border Membrane

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