2022
DOI: 10.1007/s12640-022-00487-6
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Prenatal Isoflurane Exposure Induces Developmental Neurotoxicity in Rats: the Role of Gut Microbiota

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Cited by 7 publications
(7 citation statements)
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“…In addition, previous studies found that inhalation anesthesia can directly affect the gut microbiota in rodents [ 74 , 75 ], we cannot rule out the potential effect of inhaling anesthetics on gut microbiota due to mice being anesthetized during EA stimulation. Moreover, other factors such as gender can also lead to differences in microbial composition [ 76 ].…”
Section: Discussionmentioning
confidence: 88%
“…In addition, previous studies found that inhalation anesthesia can directly affect the gut microbiota in rodents [ 74 , 75 ], we cannot rule out the potential effect of inhaling anesthetics on gut microbiota due to mice being anesthetized during EA stimulation. Moreover, other factors such as gender can also lead to differences in microbial composition [ 76 ].…”
Section: Discussionmentioning
confidence: 88%
“…Notably, the changes in microbiota after CRS modeling (Control vs. CRS) were considerably more pronounced than those following sham EA intervention (Sham vs. CRS + fEA). This difference may be attributed to the recovery of the bacterial community 1 week after intervention, although the potential impact of anesthesia on the microbiota cannot be discounted ( Serbanescu et al, 2019 ; Wang et al, 2022 ). In addition, fecal collection and behavioral testing were conducted after CRS, and the correlation between the two was analyzed.…”
Section: Discussionmentioning
confidence: 99%
“…General anesthetics can lead to dysbiosis in the gut microbiota of neonatal mice ( 87 ), and studies have shown that the pathogenesis of isoflurane-induced neurotoxicity in the developing brain may be related to the altered gut microbiota structure of juvenile rats caused by exposure ( 88 ). Recently, Wang et al ( 89 ) found that the diversity and composition of their gut microbiota were significantly altered in juvenile rats prenatally exposed to isoflurane, and reduced BDNF expression was detected in the hippocampus. The imbalance of intestinal flora may be related to the pathogenesis of postpartum cognitive impairment in neonatal rats caused by maternal isoflurane exposure, which may be related to changes in immune response and increased susceptibility to infection.…”
Section: Other Potential Mechanismsmentioning
confidence: 99%