Prenatal lead exposure and cord blood DNA methylation in the Korean Exposome Study

Park, Jaehyun; Kim, Jee Young; Kim, Esther; Kim, Woo Jin; Won, Sungho

doi:10.1016/j.envres.2021.110767

Cited by 24 publications

(15 citation statements)

References 59 publications

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“…Perinatal effects of high Pb concentrations are low birth weight, preterm delivery, pre-eclampsia and pregnancy hypertension (90,(114)(115)(116)(117). Umbilical cord blood analysis has also shown that Pb affects DNA methylation and has also confirmed the reduced intellectual abilities of children coming from pregnancies with exposure to Pb (118,119).…”

Section: Discussionmentioning

confidence: 99%

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

et al. 2021

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The growth and development of the fetus is a complex phenomenon that can be influenced by several variables. High quantities of heavy metal ions in the amniotic fluid have been linked to poor health, especially in industrial, polluted and poor areas. The aim of the present study was to assess the differences in the concentration of these ions between preterm (weeks 15-37) and term pregnancies (starting at week 37). Another objective was to compare pregnancies from two cities with different industry levels. Two sample lots from two Romanian cities were analyzed. A total of 100 patients from Timisoara were compared with 60 from Petrosani, a heavy industry city in Romania. Demographic data were collected, and amniocentesis was performed on all women. Lead (Pb), copper (Cu), nickel (Ni), cadmium (Cd), arsenic (As), iron (Fe) and zinc (Zn) concentrations were assessed. Descriptive and analytical statistics were performed using the Mann-Whitney U test for non-parametric data and the Fisher's exact test for categorical data. In addition, categorical data was represented graphically. In the Timisoara cohort, the differences in heavy metal concentrations between preterm and term pregnancies were not statistically significant. In the Petrosani cohort, however, the concentrations of Zn (P=0.02606) and Cd (P=0.01512) were higher in preterm than in term pregnancies. When comparing the two cohorts as a whole, the concentration of Pb (P=0.04513), Cd (P=0.00002), As (P=0.03027) and Zn (P<0.00001) were higher in the patients from Petrosani than in those from Timisoara. Only Cu concentrations were higher in the Timisoara cohort (P<0.00001). The concentrations of Ni (P=0.78150) and Fe (P=0.44540) did not differ statistically. Thus, amniocentesis is an important diagnostic and exploratory tool in determining differences in the concentrations of elements such as heavy metal ions. Research over a longer period of time should be carried out to examine the relation between heavy metal ions concentration and possible postnatal health outcomes.

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Section: Discussionmentioning

confidence: 99%

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

et al. 2021

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“…Preprocessing of the information on the cord blood samples, leukocyte-composition estimation, and quality-control steps were performed with the R packages ewastools [ 14 , 15 ] and minfi [ 16 ], as described previously [ 17 ]. Briefly, leukocyte compositions were estimated with Houseman’s method, with the reference panel by Salas et al with IDOL-optimized CpGs [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

Prenatal Exposure to Traffic-Related Air Pollution and the DNA Methylation in Cord Blood Cells: MOCEH Study

Park

Kim

et al. 2022

IJERPH

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Particulate matter with a diameter of ≤10 µm (PM10) and nitrogen dioxide (NO2) affect the DNA methylation in the fetus, but epigenetic studies regarding prenatal exposure to air pollution in Asia are lacking. Therefore, this study aimed to assess whether there is any association between the ambient concentrations of PM10 and NO2 and CpG methylation in the cord blood DNA by using a Korean birth cohort. The concentrations of the air pollutants were incorporated into the final LUR model by using the maternal address data. The methylation level was determined using HumanMethylationEPIC BeadChip and a linear regression analysis model. A multipollutant model including both PM10 and NO2 and models with single pollutants were used for each trimester exposure. The number of differentially methylated positions was the largest for midpregnancy exposure in both the single pollutant models and the multipollutant regression analysis. Additionally, gene-set analysis regarding midpregnancy exposure revealed four gene ontology terms (cellular response to staurosporine, positive regulation of cytoskeleton organization, neurotransmitter transport, and execution phase of apoptosis). In conclusion, these findings show an association between prenatal PM10 and NO2 exposure and DNA methylation in several CpG sites in cord blood cells, especially for midpregnancy exposure.

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“…There is evidence that long-term chronic lead exposure is associated with abnormal DNA methylation in children, and this DNA methylation may mediate lead-related myocardial damage, which may genetically affect the occurrence of SC-MI (42)(43)(44)(45). Nevertheless, more basic and clinical studies are needed to explore proven and potential mechanisms.…”

Section: Figurementioning

confidence: 99%

Lead exposure is non-linearly associated with subclinical myocardial injury in the general population without cardiovascular disease

Wang

Huang²,

Li³

et al. 2022

Front. Public Health

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Background and aimsGrowing studies have focused on the effect of lead exposure on human circulatory system, while the relationship between lead exposure and subclinical myocardial injury (SC-MI) is still poorly known. Therefore, this study was to explore the effect of lead exposure on SC-MI.MethodsThe study included 6,272 individuals aged 40 and older without cardiovascular disease (CVD) from the third National Health and Nutrition Examination Survey. Blood lead was used as an alternative marker of lead exposure. Multivariable logistic regression models, restricted cubic spline and threshold effect analyses were performed to investigate the effect of blood lead on SC-MI.ResultsAfter adjusting for age, sex, race, diabetes, hypertension, systolic blood pressure, body mass index, waist-to-hip ratio, triglycerides, total cholesterol, creatinine, fasting plasma glucose and hemoglobin Alc, higher blood lead level was independently related to higher risk of SC-MI (OR 1.047, 95% CI [1.018, 1.077]; P = 0.003). Restricted cubic spline curve showed that there was a non-linear correlation between blood lead and SC-MI. Threshold effect analysis determined that the inflection point of blood lead was 3.8 ug/dl. When the blood lead level was higher than 3.8 ug/dl, there was an independent positive correlation between blood lead level and the risk of SC-MI (OR 1.031, 95% CI [1.009, 1.053]; P < 0.01). And similar associations were also observed among subgroups of male, ≤60 years, >60 years, never smoker, non-Hispanic White, non-Hispanic Black or without hypertension and diabetes.ConclusionsBlood lead was non-linearly related to SC-MI in population free from CVD.

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Prenatal lead exposure and cord blood DNA methylation in the Korean Exposome Study

Cited by 24 publications

References 59 publications

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

Prenatal Exposure to Traffic-Related Air Pollution and the DNA Methylation in Cord Blood Cells: MOCEH Study

Lead exposure is non-linearly associated with subclinical myocardial injury in the general population without cardiovascular disease

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