Prenatal lipopolysaccharide‐exposure prevents allergic sensitization and airway inflammation, but not airway responsiveness in a murine model of experimental asthma

Abstract

This study provides first experimental evidence that LPS may already operate in prenatal life in order to modulate the development of allergies in the offspring.

Protective effects of farming on allergies and asthma: have we learnt anything since 1873?

“…Similarly, we showed that exposure of the mother to farm animals during pregnancy was strongly associated with a subsequent reduced prevalence of hayfever, asthma and eczema [20]. The importance of prenatal exposures has also been confirmed in animal models of asthma [70]. In addition, several studies have shown inverse associations between endotoxin exposure in the first year of life and asthma symptoms later in childhood [52].…”

The impact of omega-3 fatty acids on lung histopathology in mice model of chronic asthma

“…Some studies have focused on the anti-inflammatory effects of omega-3 fatty acids on asthma (Blümer et al, 2005). Wallace et al (2001) reported that omega-3 fatty acids are effective on T-helper 1 cells and eicosanoid metabolism.…”

Lactobacillus reuteri, Infant Allergy Prevention and Childhood Immune Maturation

“…Of importance is the maternal environment, suggesting that maternal immunity may be transferred or at least influence the offspring. In experimental murine models, the mother is treated with lipopolysaccharide which attenuated allergic disease and associated inflammation in offspring [22][23][24]. One study explored the effect of LPS on female BALB/c mice before conception and during pregnancy.…”