Prenatal Manganese Exposure and Long-Term Neuropsychological Development at 4 Years of Age in a Population-Based Birth Cohort

Andiarena, Ainara; Irizar, Amaia; Molinuevo, Amaia; Urbieta, Nerea; Babarro, Izaro; Subiza-Pérez, Mikel; Santa‐Marina, Loreto; Ibarluzea, Jesús; Lertxundi, Aitana

doi:10.3390/ijerph17051665

Cited by 8 publications

(3 citation statements)

References 47 publications

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“…Prospective studies found prenatal Mn exposure was not associated with motor outcomes from the McCarthy Scales of Children’s Abilities at 4 or 5 years of age. 47 , 48 Chiu et al. found higher prenatal Mn exposure was associated with better body stability in 11- to 14-y-old adolescent males compared with females.…”

Section: Introductionmentioning

confidence: 99%

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants

McBride,

Bhattacharya,

Sucharew

et al. 2024

Environ Health Perspect

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Background: Manganese (Mn) plays a significant role in both human health and global industries. Epidemiological studies of exposed populations demonstrate a dose-dependent association between Mn and neuromotor effects ranging from subclinical effects to a clinically defined syndrome. However, little is known about the relationship between early life Mn biomarkers and adolescent postural balance. Objectives: This study investigated the associations between childhood and adolescent Mn biomarkers and adolescent postural balance in participants from the longitudinal Marietta Communities Actively Researching Exposures Study (CARES) cohort. Methods: Participants were recruited into CARES when they were 7–9 y old, and reenrolled at 13–18 years of age. At both time points, participants provided samples of blood, hair, and toenails that were analyzed for blood Mn and lead (Pb), serum cotinine, hair Mn, and toenail Mn. In adolescence, participants completed a postural balance assessment. Greater sway indicates postural instability (harmful effect), whereas lesser sway indicates postural stability (beneficial effect). Multivariable linear regression models were conducted to investigate the associations between childhood and adolescent Mn biomarkers and adolescent postural balance adjusted for age, sex, height–weight ratio, parent/caregiver intelligence quotient, socioeconomic status, blood Pb, and serum cotinine. Results: CARES participants who completed the adolescent postural balance assessment ( ) were 98% White and 54% female and had a mean age of 16 y (range: 13–18 y). In both childhood and adolescence, higher Mn biomarker concentrations were significantly associated with greater adolescent sway measures. Supplemental analyses revealed sex-specific associations; higher childhood Mn biomarker concentrations were significantly associated with greater sway in females compared with males. Discussion: This study found childhood and adolescent Mn biomarkers were associated with subclinical neuromotor effects in adolescence. This study demonstrates postural balance as a sensitive measure to assess the association between Mn biomarkers and neuromotor function. https://doi.org/10.1289/EHP13381

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Section: Introductionmentioning

confidence: 99%

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants

McBride,

Bhattacharya,

Sucharew

et al. 2024

Environ Health Perspect

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“…The results of numerous studies indicate that adverse environmental conditions and stress during fetal development can lead to a whole range of functional and structural disorders in body systems (Scott-Goodwin, Puerto, and Moreno, 2016;Gonzalez-Casanova et al, 2018). Thus, modern experimental and clinical studies have shown the development of pathological changes in the functional parameters of the brain during early postnatal ontogenesis in response to acute exposure to Mn in the prenatal period (Andiarena et al, 2020;Beasley et al, 2022). However, the effects of low-level Mn exposure during prenatal development on adaptive responses, behavior, and cognitive functions of the offspring are still far from being fully understood.…”

Section: Introductionmentioning

confidence: 99%

Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development

Kazakova,

Marshinskaya,

Notova

2024

BioComm

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The study evaluated the effects of prenatal exposure to manganese (Mn) on the functional state of offspring at later stages of postnatal development (PND). Female rats were treated with MnSO4·5H2O in the diet at a dose of 1433 mg/kg starting 28 days prior to breeding and through gestation. The pregnancy proceeded normally, no physical abnormalities were observed. There was a lag in physical development of the offspring, which was characterized by a later opening of the eyes, the formation of a coat and the eruption of incisors, the weight gain was attenuated from PND 0-84. Offspring had hyperactive behavior and deterioration in spatial learning and memory. The level of Mn in the blood serum and cerebral cortex was higher than the control values by 11 % and 53 % respectively. The acetylcholinesterase level in the serum was higher by 47 %. These findings highlight the risk of prenatal exposure to subchronic doses of Mn.

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“…The fetus is particularly susceptible to environmental threats. Gestational exposure to environmental toxicants has been related not only to fetal growth and development but also to long-term health challenges [13][14][15]. Thus, assessing the relationship between prenatal pollutants exposure and the features of childhood growth is desirable, and identifying which period of growth is most sensitive to prenatal environmental pollutants exposure is essential for infants' and children's development.…”

Section: Introductionmentioning

confidence: 99%

Cord Blood Manganese Concentrations in Relation to Birth Outcomes and Childhood Physical Growth: A Prospective Birth Cohort Study

Dai

Zhang

et al. 2021

Nutrients

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Gestational exposure to manganese (Mn), an essential trace element, is associated with fetal and childhood physical growth. However, it is unclear which period of growth is more significantly affected by prenatal Mn exposure. The current study was conducted to assess the associations of umbilical cord-blood Mn levels with birth outcomes and childhood continuous physical development. The umbilical cord-blood Mn concentrations of 1179 mother–infant pairs in the Sheyang mini birth cohort were measured by graphite furnace atomic absorption spectrometry (GFAAS). The association of cord-blood Mn concentrations with birth outcomes, and the BMI z-score at 1, 2, 3, 6, 7 and 8 years old, were estimated separately using generalized linear models. The relationship between prenatal Mn exposure and BMI z-score trajectory was assessed with generalized estimating equation models. The median of cord-blood Mn concentration was 29.25 μg/L. Significantly positive associations were observed between Mn exposure and ponderal index (β, regression coefficient = 0.065, 95% CI, confidence interval: 0.021, 0.109; p = 0.004). Mn exposure was negatively associated with the BMI z-score of children aged 1, 2, and 3 years (β = −0.383 to −0.249, p < 0.05), while no significant relationships were found between Mn exposure and the BMI z-score of children at the age of 6, 7, and 8 years. Prenatal Mn exposure was related to the childhood BMI z-score trajectory (β = −0.218, 95% CI: −0.416, −0.021; p = 0.030). These results indicated that prenatal Mn exposure was positively related to the ponderal index (PI), and negatively related to physical growth in childhood, which seemed most significant at an early stage.

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Prenatal Manganese Exposure and Long-Term Neuropsychological Development at 4 Years of Age in a Population-Based Birth Cohort

Cited by 8 publications

References 47 publications

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants

Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development

Cord Blood Manganese Concentrations in Relation to Birth Outcomes and Childhood Physical Growth: A Prospective Birth Cohort Study

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