Prenatal maternal alcohol exposure: diagnosis and prevention of fetal alcohol syndrome

Hur, Young Min; Choi, Jiwon; Park, Sunwha; Oh, Sarah Soyeon; Kim, Young Ju

doi:10.5468/ogs.22123

Cited by 5 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Investigating the impact of particulate matter on adverse pregnancy outcomes in crucial in the context of fetal programming, as external stimuli experienced by the fetus in the uterus, such as oxidative stress, maternal physiological changes, and preeclampsia, can have long-term effects on fetal health (Hur et al 2022 ; Kwon and Kim 2017 ; Öztürk and Türker 2021 ). Previous retrospective studies have suggested that particulate matter exposure during pregnancy may lead to fetal neurodevelopmental delay, possibly due to inflammation, although the underlying mechanisms are not fully understood (Lin et al 2022 ; Su et al 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Personal exposure of PM2.5 and metabolic syndrome markers of pregnant women in South Korea: APPO study

Jeong,

Park,

Kwon

et al. 2023

Environ Sci Pollut Res

Self Cite

View full text Add to dashboard Cite

We examined the association between exposure to PM2.5, focused on individual exposure level, and metabolic dysfunction during pregnancy. APPO study (Air Pollution on Pregnancy Outcome) was a prospective, multicenter, observational cohort study conducted from January 2021 to March 2023. Individual PM2.5 concentrations were calculated using a time-weighted average model. Metabolic dysfunction during pregnancy was assessed based on a modified definition of metabolic syndrome and its components, accounting for pregnancy-specific criteria. Exposure to PM2.5 during pregnancy was associated with worsened metabolic parameters especially glucose metabolism. In comparison to participants exposed to the low PM2.5 group, those exposed to high PM2.5 levels exhibited increased odds of gestational diabetes mellitus (GDM) after adjusting for confounding variables in different adjusted models. Specifically, in model 1, the adjusted odds ratio (aOR) was 3.117 with a 95% confidence interval (CI) of 1.234–7.870; in model 2, the aOR was 3.855 with a 95% CI of 1.255–11.844; in model 3, the aOR was 3.404 with a 95% CI of 1.206–9.607; and in model 4, the aOR was 2.741 with a 95% CI of 0.712–10.547. Exposure to higher levels of PM2.5 during pregnancy was associated with a tendency to worsen metabolic dysfunction markers specifically in glucose homeostasis. Further research is needed to investigate the mechanisms underlying the effects of ambient PM2.5 on metabolic dysfunction during pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Personal exposure of PM2.5 and metabolic syndrome markers of pregnant women in South Korea: APPO study

Jeong,

Park,

Kwon

et al. 2023

Environ Sci Pollut Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recognized risk factors for this condition include maternal alcohol consumption, 7 and rarely, maternal phenylketonuria, maternal infections with cytomegalovirus, toxoplasmosis, rubella, or influenza during pregnancy and vascular/hypoxic insults to the mother 3 . Alcohol is considered a destructive agent to CC development, 8 and as such, it is highly recommended that maternal alcohol consumption is avoided in all trimesters of pregnancy 9 . Advanced maternal age, associated with an increased probability of chromosomal anomalies, may increase the risk of ACC 3 .…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

“…3 Alcohol is considered a destructive agent to CC development, 8 and as such, it is highly recommended that maternal alcohol consumption is avoided in all trimesters of pregnancy. 9 Advanced maternal age, associated with an increased probability of chromosomal anomalies, may increase the risk of ACC. 3 Fetuses with other cerebral abnormalities such as malformations of cortical development are at a greater risk of ACC.…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

Agenesis of the corpus callosum: What to tell expecting parents?

Tsai,

Shinar

2023

Prenatal Diagnosis

View full text Add to dashboard Cite

Agenesis of the corpus callosum (ACC) is one of the most common brain malformations, with an incidence estimated to range from 0.5 to 70 in 10,000 among the general population. Prenatal diagnosis is made via ultrasound; however, fetal MRI is useful to confirm or exclude the presence of associated cerebral abnormalities–mostly cortical malformations–that may affect postnatal prognosis. When no additional central nervous system (CNS) or extra CNS anomalies are identified and no genetic cause is found, an isolated ACC is diagnosed. Overall, in cases of ACC, an underlying genetic cause can be identified in up to 12.5% with chromosomal microarray (CMA) and up to 47% with whole exome sequencing (WES). In cases where ACC is the only anomaly detected, the yield of WES is 30%. Postnatal outcomes are variable and depend on whether the condition is isolated or not. In truly isolated ACC, outcomes range from normal in 65% of cases through mild to severe neurodevelopmental impairments in 35% of cases. An interdisciplinary team of medical experts is key in guiding parents toward informed decision‐making in pregnancies complicated by ACC. Considering current and expected advancements in genetic testing and imaging technologies in upcoming years, we herein summarize current recommendations for the management and prenatal counseling of expecting parents of fetuses with ACC. Our review pertains primarily to expecting parents of fetuses with complete ACC.

show abstract

Effects of PM 2.5 exposure on metabolic dysfunction during pregnancy via personalized measurement of pollutant concentration in South Korea: A multicenter prospective cohort, air pollution on pregnancy outcome (APPO) study

Jeong

Park

Kwon

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Background Ambient particulate matter (PM) is a trigger factor for metabolic dysfunction. This study aimed to evaluate the associations between PM exposure and metabolic dysfunction in pregnancy. Methods This prospective, multicentre, observational, cohort study was conducted from January 2021 to June 2022. A total of 333 women with singleton pregnancies were recruited. For individual measurement of PM2.5 levels, an AirguardK® was installed inside the participants’ houses. Time-activity logs were recorded to predict each participant’s personal exposure to PM2.5. The participants were divided into groups according to the concentration of PM2.5 calculated by a time-weighted average model. We used the Student t-test and chi-squared test (or Fisher’s exact test) to evaluate changes in metabolic compound levels, blood pressure (BP), glucose intolerance, and lipid profiles, including serum triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratios. Logistic and linear regression models were used to analyse the association between PM2.5 exposure and metabolic dysfunction, using odds ratios (ORs) and 95% confidence intervals (CIs). Results PM2.5 exposure during pregnancy worsened metabolic dysfunction. Third trimester BP was elevated in those participants exposed to higher levels of PM2.5 (p <0.05). The incidence of gestational diabetes mellitus (GDM) was constantly higher in those exposed to more PM2.5, regardless of the PM2.5 cut-off level (PM2.5 ≥10 µg/m3, 7.91 % vs. 16.09 %, p <0.05; PM2.5 ≥25 µg/m3, 7.91 % vs. 26.67 %, p <0.05). The proportion with a TG/HDL-C ratio ≥3.0 was significantly higher when PM2.5 was ≥10 µg/m3 (75.3 % vs. 83.0 %, p <0.05). Triglyceride levels were significantly higher in the PM2.5 ≥25 µg/m3 group (p=0.0171). We found an increased risk of elevated BP (adjusted OR [aOR]: 2.228, 95% CI: 1.115–4.449) and GDM (aOR 2.263, 95% CI 1.106–5.039) in the third trimester after adjusting for confounders. Conclusion Exposure to PM2.5 worsens metabolic dysfunction in pregnancy. Further studies are required to investigate the mechanisms by which ambient PM affects metabolic dysfunction in pregnancy.

show abstract

Prenatal maternal alcohol exposure: diagnosis and prevention of fetal alcohol syndrome

Cited by 5 publications

References 47 publications

Personal exposure of PM2.5 and metabolic syndrome markers of pregnant women in South Korea: APPO study

Personal exposure of PM2.5 and metabolic syndrome markers of pregnant women in South Korea: APPO study

Agenesis of the corpus callosum: What to tell expecting parents?

Effects of PM 2.5 exposure on metabolic dysfunction during pregnancy via personalized measurement of pollutant concentration in South Korea: A multicenter prospective cohort, air pollution on pregnancy outcome (APPO) study

Contact Info

Product

Resources

About