Prenatal maternal depression symptoms and nutrition, and child cognitive function

Barker, Edward D.; Kirkham, Natasha Z.; Ng, Jane; Jensen, Sarah

doi:10.1192/bjp.bp.113.129486

Cited by 129 publications

(127 citation statements)

References 27 publications

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“…Barker and colleagues found prenatal depressive symptoms were negatively associated with cognitive function in 8-year old offspring, which was partially mediated through prenatal nutrition. These results were robust to postnatal depression and nutrition, although were modest in effect size (Barker et al, 2013). Santucci and colleagues did not find evidence of an association between un-medicated prenatal depressive disorder (diagnosed with the Structured Clinical Interview for DSM-IV ) and the MDI or PDI scales of the BSID-II at any point between 12 and 78 months postnatally (Santucci et al, 2014).…”

Section: Discussionmentioning

confidence: 82%

“…Primarily, this research has focused specifically on the effects of medication treatment for depression in pregnancy (most commonly with SSRIs) (Hanley et al, 2013). Research that has attempted to estimate the functional neurodevelopmental effects of prenatal maternal depression independent of medication to treat depression is scarce and has resulted in inconsistent, primarily null findings (Barker et al, 2013; Nulman et al, 2015, 2012; Santucci et al, 2014). However, research examining brain structure in preschoolers found women's second trimester depression scores negatively correlated with children's cortical thickness in right inferior frontal and middle temporal regions, which has been associated with negative neurodevelopmental outcomes (Lebel et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Assessing the Independent and Joint Effects of Unmedicated Prenatal Depressive Symptoms and Alcohol Consumption in Pregnancy and Infant Neurodevelopmental Outcomes

Bandoli

Coles

Kable

et al. 2016

Alcoholism Clin & Exp Res

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Background Prenatal alcohol exposure (PAE) is an established risk factor for neurodevelopmental deficits in the offspring. Prenatal depression has been associated with neurodevelopmental deficits in the offspring, although investigations into un-medicated prenatal depression have been inconsistent. We hypothesized that un-medicated prenatal depressive symptoms would independently and jointly with PAE predict neurodevelopmental outcomes in infant offspring. Methods We studied 344 participants from a randomized clinical trial of multivitamin supplements in pregnant women in Ukraine. Women were recruited based upon peri-conceptional alcohol use and followed up to 12 months postpartum. Prenatal depressive symptoms were assessed at approximately 32 weeks of gestation using the Beck Depression Scale. Neurodevelopment was assessed with the Bayley Scales for Infant Development II Mental Development Index (MDI) and Psychomotor Development Index (PDI) at 6 and 12 months postpartum. Generalized linear regression models were constructed to assess the independent and joint effects of prenatal depressive symptoms and PAE in models adjusted for sociodemographic and pregnancy characteristics. Results PAE was independently associated with deficits in neurodevelopmental outcomes at 6 and 12 months, however, level of prenatal depressive symptoms was not. We found marginal evidence of synergism of depressive symptoms and PAE, with larger deficits in those with both exposures observed for the PDI-6 months (p=0.05) and MDI-12 months (p=0.09). Additionally, there was a suggestion of sexual dimorphism; females had stronger deficits from joint exposures than males (depressive symptom (MDI-6 months) female: −8.28, 95% CI −13.06, −3.49; male: 0.68, 95% CI −4.58, 5.94; p for interaction 0.04). While not statistically significant for the MDI or PDI at 12 months, the trend persisted. Conclusion Infants exposed to PAE and prenatal depression may be at an increased risk of neurodevelopmental deficits. Healthcare providers should be aware of this possible synergism in their efforts to mitigate the neurodevelopmental effects of these co-occurring exposures.

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Assessing the Independent and Joint Effects of Unmedicated Prenatal Depressive Symptoms and Alcohol Consumption in Pregnancy and Infant Neurodevelopmental Outcomes

Bandoli

Coles

Kable

et al. 2016

Alcoholism Clin & Exp Res

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“…These results are in line with prior studies [25] . Maternal depression during pregnancy has been suggested to influence the developing fetus by altering the intra-uterine environment and interfering with neurodevelopmental processes, which could result in atypical cognitive and behavioral development [26] . However, this association could also be due to shared predictors of prenatal maternal depression and child development, such as socioeconomic disadvantage [27,28] or unhealthy behaviors (smoking, alcohol use).…”

Section: Patterns Of Association Between Maternal Depression and Chilmentioning

confidence: 99%

Persistent maternal depressive symptoms trajectories influence children's IQ: The EDEN mother-child cohort

et al. 2016

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for The EDEN Mother–Child Cohort Study GroupInternational audienceBackground: This study assessed the association between timing and course of maternal depression from pregnancy onwards and children's cognitive development at ages 5 to 6. Potential interaction effects with child sex and family socioeconomic status were explored.Methods: One thousand thirty-nine mother–child pairs from the French EDEN mother–child birth cohort were followed from 24 to 28 weeks of pregnancy onwards. Based on Center for Epidemiological Studies Depression (CES-D) and Edinburgh Postnatal Depression Scale (EPDS) scores assessed at six timepoints, longitudinal maternal depressive symptom trajectories were calculated with a group-based semiparametric method. Children's cognitive function was assessed at ages 5 to 6 by trained interviewers with the Wechsler Preschool and Primary Scale of Intelligence Third Edition (WPPSI-III), resulting in three composite scores: Verbal IQ (VIQ), Performance IQ (PIQ), and Full-Scale IQ (FSIQ).Results: Five trajectories of maternal symptoms of depression could be distinguished: no symptoms, persistent intermediate-level depressive symptoms, persistent high depressive symptoms, high symptoms in pregnancy only, and high symptoms in the child's preschool period only. Multiple linear regression analyses showed that, compared to children of mothers who were never depressed, children of mothers with persistent high levels of depressive symptoms had reduced VIQ, PIQ, and FSIQ scores. This association was moderated by the child's sex, boys appearing especially vulnerable in case of persistent maternal depression.Conclusions: Chronicity of maternal depression predicts children's cognitive development at school entry age, particularly in boys. As maternal mental health is an early modifiable influence on child development, addressing the treatment needs of depressed mothers may help reduce the associated burden on the next generation

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“…However, a literature review performed in the PubMed and SciELO databases, using the keywords food intake, pregnancy, mental health, and variations of dietary patterns and food patterns, retrieved only a few studies that evaluated the relationship between dietary patterns and mental health within the context of pregnancy. 9,10 The summary findings of a recent systematic review pointed to positive associations between poor-quality, unhealthy diets and antenatal depressive and stress symptoms, but the existing evidence base is limited. 11 Within this context, the objective of this study is to evaluate the association of dietary patterns and consumption of specific food groups with mental disorders in pregnant women from southern Brazil.…”

Section: Introductionmentioning

confidence: 99%

Association between dietary patterns and mental disorders in pregnant women in Southern Brazil

Paskulin

Drehmer

Olinto

et al. 2017

Rev. Bras. Psiquiatr.

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Objective: To evaluate the association between dietary patterns and mental disorders among pregnant women in southern Brazil. Methods: Cross-sectional study with 712 pregnant women recruited from the Study of Food Intake and Eating Behaviors in Pregnancy (ECCAGe). Food intake assessment was performed using the Food Frequency Questionnaire. Dietary patterns were identified by cluster analysis. The Primary Care Evaluation of Mental Disorders (PRIME-MD) was used to evaluate participants' mental health. Poisson regression models with robust variance were fitted to estimate prevalence ratios (PR). Results: In the adjusted models, there was a high prevalence of major depressive disorder among women with low fruit intake (43%, PR 1.43, 95%CI 1.04-1.95) and high sweets and sugars intake (91%, PR 1.91, 95%CI 1.19-3.07). Women with a common-Brazilian dietary pattern had higher prevalence of major depressive disorder compared to those with a varied consumption pattern (PR 1.43, 95%CI 1.01-2.02). Low intake of beans was significantly associated with generalized anxiety disorder (PR 1.40, 95%CI 1.01-1.93). Conclusions: Low consumption of fruits and beans and intake of the common-Brazilian dietary pattern during pregnancy were associated with higher prevalence of mental disorders. These results reinforce the importance of an adequate dietary intake to ensure better mental health in pregnancy.

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Prenatal maternal depression symptoms and nutrition, and child cognitive function

Abstract: Prenatal interventions aimed at the well-being of children of parents with depression should consider targeting the nutritional environment.

Cited by 129 publications

References 27 publications

Assessing the Independent and Joint Effects of Unmedicated Prenatal Depressive Symptoms and Alcohol Consumption in Pregnancy and Infant Neurodevelopmental Outcomes

Assessing the Independent and Joint Effects of Unmedicated Prenatal Depressive Symptoms and Alcohol Consumption in Pregnancy and Infant Neurodevelopmental Outcomes

Persistent maternal depressive symptoms trajectories influence children's IQ: The EDEN mother-child cohort

Association between dietary patterns and mental disorders in pregnant women in Southern Brazil

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