Prenatal maternal Inflammation, childhood cognition and adolescent depressive symptoms

Pike, Madeline R.; Lipner, Emily; O'Brien, Kathleen J.; Breen, Elizabeth C.; Cohn, Barbara A.; Cirillo, Piera M.; Krigbaum, Nickilou Y.; Kring, Ann M.; Olino, Thomas M.; Alloy, Lauren B.; Ellman, Lauren M.

doi:10.1016/j.bbi.2024.05.012

Cited by 3 publications

References 98 publications

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Neuroinflammation and mental health outcomes in adolescents living with HIV

Mudra Rakshasa-Loots,

Vera,

Laughton

2024

Current Opinion in HIV and AIDS

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Purpose of review Adolescents living with HIV show chronic inflammation, which in turn has been linked to mental health outcomes in the general population. The increased risk for mental health issues in adolescents with HIV may thus be driven by HIV-related inflammation. In this review, we discuss the associations between peripheral and central nervous system inflammation and mental health outcomes in adolescents with HIV. Recent findings Preclinical models indicate that expression of HIV viral proteins early in life may lead to neuroinflammation and behavioural deficits in adolescence. Clinical evidence is available primarily in the general population and in adults with HIV, and suggests that inflammatory biomarkers such as IL-6 and TNF-α may be associated with depressive symptoms. Only one study has explored these relationships in adolescents with HIV, and did not find that inflammatory biomarkers in the blood or brain were linked to depressive symptoms. Current research in this field focuses overwhelmingly on peripheral inflammatory biomarkers (compared to neuroimaging biomarkers) and on depression (compared to other mental health conditions). Summary There is strong evidence to suggest that neuroinflammation and peripheral inflammation may play a role in the development of mental health issues in adolescents, but research in adolescents with HIV is sparse. Characterizing the relationship between inflammation and mental health in adolescents with HIV may help improve the prediction, prevention, early intervention, and treatment of mental health issues in this population.

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Neuroinflammation and mental health outcomes in adolescents living with HIV

Mudra Rakshasa-Loots,

Vera,

Laughton

2024

Current Opinion in HIV and AIDS

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Decreased hippocampal neurite density in middle-aged/aging adults following prenatal exposure to higher levels of maternal inflammation

Mohyee,

Elliott,

Pike

et al. 2024

Preprint

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In animal models, exposure to heightened maternal inflammation in utero is associated with altered offspring hippocampal development, including reduced dendritic arborization and density. However, the effects of prenatal maternal inflammation (PNMI) on offspring hippocampal microstructure in humans remains unclear. Here, we examined the relationship between exposure to PNMI and neurite density in the hippocampus and its subfields among offspring during late middle age. Participants included 72 mother-offspring dyads from the Child Health and Development Studies (CHDS) cohort. Data for four inflammatory biomarkers (IL-6, IL-8, IL-1 receptor antagonist [IL-1RA], and soluble TNF receptor-II [sTNF-RII]) were available from first and second trimester maternal sera. Neurite density in the offspring hippocampus and its subfields was estimated using microstructural modeling of offsprings' diffusion-weighted Magnetic Resonance Imaging data (mean age of offspring at imaging = 59 years; 51% male). We estimated the relationship between each biomarker and region-of-interest's neurite density. Higher first trimester maternal IL-1RA and IL-6 levels were associated with lower offspring hippocampal neurite density. These relationships were specific to the CA3, CA4, dentate gyrus, and subiculum subfields. In addition, higher second trimester IL-6 was associated with lower subiculum neurite density. Our findings reveal that exposure to heightened prenatal levels of maternal inflammation is linked to altered offspring hippocampal microstructure in late middle age, which could have implications for memory decreases during this period and may be relevant for understanding risk of aging-related cognitive changes.

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Association between psychiatric symptoms with multiple peripheral blood sample test: a 10-year retrospective study

Qiu,

Yu,

Kuang

et al. 2024

Front. Psychiatry

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BackgroundPsychiatric illness is thought to be a brain somatic crosstalk disorder. However, the existing phenomenology-based Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic framework overlooks various dimensions other than symptoms. In this study, we investigated the associations between peripheral blood test indexes with various symptom levels of major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) to explore the availability of peripheral blood test indexes.MethodsWe extracted cases diagnosed with MDD, BD, and SCZ at West China Hospital from 2009 to 2021, translated their main complaints into Research Domain Criteria (RDoC) symptom severity scores using nature language processing (NLP), and collected their detailed psychiatric symptoms and peripheral blood test results. Then, generalized linear models were performed between seven types of peripheral blood test values with their transformed RDoC scores and detailed symptom information adjusted for age, gender, smoking, and alcohol history.ResultsSeveral inflammatory-related indexes were strongly associated with the negative valence system (NVS) domain (basophil percentage adjusted β = 0.275, lymphocyte percentage adjusted β = 0.271, monocyte percentage adjusted β = 0.223, neutrophil percentage adjusted β = −0.310, neutrophil count adjusted β = −0.301, glucose adjusted β = −0.287, leukocyte count adjusted β = −0.244, NLR adjusted β = −0.229, and total protein adjusted β = −0.170), the positive valence system (PVS) domain (monocyte percentage adjusted β = 0.228, basophil count adjusted β = 0.176, and glutamyl transpeptidase adjusted β = 0.171), and a wide range of mood, reward, and psychomotor symptoms. In addition, glucose, urea, urate, cystatin C, and albumin showed considerable associations with multiple symptoms. In addition, based on the direction of associations and the similarity of symptoms in terms of RDoC thinking, it is suggested that “positive” mood symptoms like mania and irritability and “negative” mood symptoms like depression and anxiety might be on a continuum considering their opposite relationships with similar blood indexes.LimitationsThe cross-sectional design, limited symptoms record, and high proportion of missing values in some other peripheral blood indexes limited our findings.ConclusionThe proportion of high inflammatory indexes in SCZ was relatively high, but in terms of mean values, SCZ, BD, and MDD did not differ significantly. Inflammatory response showed a strong correlation with NVS, PVS, and a range of psychiatric symptoms especially mood symptoms, psychomotor symptoms, and cognitive abilities.

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Prenatal maternal Inflammation, childhood cognition and adolescent depressive symptoms

Cited by 3 publications

References 98 publications

Neuroinflammation and mental health outcomes in adolescents living with HIV

Neuroinflammation and mental health outcomes in adolescents living with HIV

Decreased hippocampal neurite density in middle-aged/aging adults following prenatal exposure to higher levels of maternal inflammation

Association between psychiatric symptoms with multiple peripheral blood sample test: a 10-year retrospective study

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