Prenatal maternal stress alters depression-related symptoms in a strain - and sex-dependent manner in rodent offspring

Enayati, Mohsen; Mosaferi, Belal; Homberg, Judith R.; Diniz, Danielle Mendes; Salari, Ali-Akbar

doi:10.1016/j.lfs.2020.117597

Cited by 41 publications

(19 citation statements)

References 64 publications

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“…Significant increases in the levels of these cytokines are also correlated with increased depression in humans (Dhabhar et al, 2009;Dowlati et al, 2010;Loftis et al, 2010;Madrigal et al, 2002;O'Connor et al, 2003;Raison et al, 2006;Zunszain et al, 2011). Animals studies also confirmed that increased TNF-α or IL-1β in rodents is associated with depression-like behaviour (Amani et al, 2018(Amani et al, , 2019Ayatollahi et al, 2017;Babri et al, 2014;Bashiri et al, 2020;Enayati et al, 2020;Kosari-Nasab et al, 2018a, 2018bMajidi et al, 2016;Majidi-Zolbanin et al, 2015;Rahimi et al, 2020;Zeraati et al, 2019). Therefore, it is conceivable to conclude that pro-inflammatory cytokines such as TNFα and IL-1β in type 2 diabetic mice resulted in increased depression-like behaviour.…”

Section: Discussionmentioning

confidence: 81%

Swimming exercise decreases depression‐like behaviour and inflammatory cytokines in a mouse model of type 2 diabetes

Gilak-Dalasm

Peeri

Azarbayjani

2021

Experimental Physiology

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Clinical and experimental studies have shown that type 2 diabetes is associated with depression-related disorders. Inflammation has been identified as a common mechanism in both type 2 diabetes and depression. Several studies have suggested that swimming exercise might be able to reduce depression-related symptoms. The present study aimed to explore whether swimming exercise can decrease depressionlike behaviour in type 2 diabetic mice. To induce type 2 diabetes, male C57BL6 mice were treated with a high-fat diet and streptozocin. Type 2 diabetic animals were subjected to swimming exercise for 4 weeks. Then, depression-like behaviours were evaluated by sucrose preference, novelty-suppressed feeding, social interaction and tail suspension tests. We also measured levels of glucose, insulin and pro-inflammatory cytokines such as interleukin-1β and tumour necrosis factor-α in the serum of animals.The results indicated that type 2 diabetes significantly increased anhedonia-and depression-like behaviours in mice. We also found significant increases in glucose, insulin and inflammatory cytokines in diabetic mice. Moreover, swimming exercise reduced anhedonia-and depression-like behaviour in type 2 diabetic mice. Swimming exercise also decreased glucose and inflammatory cytokines in the serum of mice with type 2 diabetes. Collectively, this study demonstrates that swimming exercise decreased depression-like behaviour by reducing inflammation in type 2 diabetic mice.Further clinical studies are needed to validate these findings in patients with type 2 diabetes.

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Section: Discussionmentioning

confidence: 81%

Swimming exercise decreases depression‐like behaviour and inflammatory cytokines in a mouse model of type 2 diabetes

Gilak-Dalasm

Peeri

Azarbayjani

2021

Experimental Physiology

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“…Daily application of restraint or unpredictable stress protocols during almost the entire gestational period, in various rat and mouse strains, produces several stress-related and emotional alterations in the offspring later in life (Table 1 ). One of the most consistently reproduced phenotypes observed in these models, is the enhancement of anxiety behaviors, often accompanied by reduced locomotor and exploratory activities 45 – 49 . Additionally, these anxiety effects can predispose the offspring to other compulsive addictive behaviors like alcohol consumption 48 (Table 1 ).…”

Section: Early-life Stress Models: Behavioral Outcomesmentioning

confidence: 94%

“…Depressive-like symptoms were also reported after gestational exposure to stress in rats 49 , 58 , though the evidence is more limited (Table 1 ).…”

Section: Early-life Stress Models: Behavioral Outcomesmentioning

confidence: 99%

Serotonin-related rodent models of early-life exposure relevant for neurodevelopmental vulnerability to psychiatric disorders

2021

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Mental disorders including depression and anxiety are continuously rising their prevalence across the globe. Early-life experience of individuals emerges as a main risk factor contributing to the developmental vulnerability to psychiatric disorders. That is, perturbing environmental conditions during neurodevelopmental stages can have detrimental effects on adult mood and emotional responses. However, the possible maladaptive neural mechanisms contributing to such psychopathological phenomenon still remain poorly understood. In this review, we explore preclinical rodent models of developmental vulnerability to psychiatric disorders, focusing on the impact of early-life environmental perturbations on behavioral aspects relevant to stress-related and psychiatric disorders. We limit our analysis to well-established models in which alterations in the serotonin (5-HT) system appear to have a crucial role in the pathophysiological mechanisms. We analyze long-term behavioral outcomes produced by early-life exposures to stress and psychotropic drugs such as the selective 5-HT reuptake inhibitor (SSRI) antidepressants or the anticonvulsant valproic acid (VPA). We perform a comparative analysis, identifying differences and commonalities in the behavioral effects produced in these models. Furthermore, this review discusses recent advances on neurodevelopmental substrates engaged in these behavioral effects, emphasizing the possible existence of maladaptive mechanisms that could be shared by the different models.

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“…Exposure to stress across the lifespan can impact the outcome of the response on food intake in a sex-, age-and diet-dependent manner, in both humans (reviewed in ( 128)), and rodents (44,45,91,127,(129)(130)(131)(132). In rodents, stress exposure throughout gestation does not affect baseline food intake in males (91,129), but decreases baseline intake in females (91), and reduces sucrose preference in both sexes (129,132). Combining stress exposures in two developmental periods can produce synergistic effects.…”

Section: Timing Of Stress Across the Lifespanmentioning

confidence: 99%

A Framework for Developing Translationally Relevant Animal Models of Stress-Induced Changes in Eating Behavior

François¹,

Fernández-Gayol²,

Zeltser³

2022

Biological Psychiatry

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Prenatal maternal stress alters depression-related symptoms in a strain - and sex-dependent manner in rodent offspring

Cited by 41 publications

References 64 publications

Swimming exercise decreases depression‐like behaviour and inflammatory cytokines in a mouse model of type 2 diabetes

Swimming exercise decreases depression‐like behaviour and inflammatory cytokines in a mouse model of type 2 diabetes

Serotonin-related rodent models of early-life exposure relevant for neurodevelopmental vulnerability to psychiatric disorders

A Framework for Developing Translationally Relevant Animal Models of Stress-Induced Changes in Eating Behavior

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