Prenatal mercury exposure and birth weight

Vigeh, Mohsen; Nishioka, Emiko; Ohtani, Kazuhiro; Omori, Yuki; Matsukawa, Tetsuya; Koda, Shigeki; Yokoyama, Kazuhito

doi:10.1016/j.reprotox.2018.01.002

Cited by 53 publications

(31 citation statements)

References 44 publications

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“…Mercury concentrations over the suggested limit of 23.7 nmol/L (4.75 ng/mL) were found in 1 of every 10 donors. Prenatal exposure to mercury was reported to be associated with reduced fetal growth and lower birthweight, as well as with adverse effects on neonates' neurobehavioral development, poorer language skills at the age of 5 years and with the increased risk of respiratory infections during the first year of life . Mercury and lead are identified as one of the developmental neurotoxicants .…”

Section: Discussionmentioning

confidence: 99%

Environmental pollutants in blood donors: The multicentre Norwegian donor study

Averina

Hervig

Huber

et al. 2020

Transfusion Medicine

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Objectives The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background Transfused blood may be a potential source of exposure to heavy metals and organic pollutants and presents a risk to vulnerable patient groups such as premature infants. Methods/Materials Donors were randomly recruited from three Norwegian blood banks: in Bergen, Tromsø and Kirkenes. Selected heavy metals were measured in whole blood using inductively coupled plasma mass spectrometry (ICP‐MS), and perfluoroalkyl substances (PFAS) were measured in serum by ultrahigh‐pressure liquid chromatography coupled with a triple‐quadrupole mass spectrometer (UHPLC‐MS/MS). Results Almost 18% of blood donors had lead concentrations over the limit suggested for transfusions in premature infants (0.09 μmol/L). About 11% of all donors had mercury concentrations over the suggested limit of 23.7 nmol/L. Cadmium was higher than the limit, 16 nmol/L, in 4% of donors. Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations were over the suggested limit of 0.91 ng/mL in 68% and 100% of the donors, respectively. PFAS concentrations and heavy metal concentrations increased with donor's age. Conclusion A considerable percentage of donors had lead, PFOS and PFOA concentrations over the suggested limits. In addition, at each study site, there were donors with high mercury and cadmium concentrations. Selecting young donors for transfusions or measurements of pollutants in donor blood may be a feasible approach to avoid exposure through blood transfusions to vulnerable groups of patients such as premature infants.

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Section: Discussionmentioning

confidence: 99%

Environmental pollutants in blood donors: The multicentre Norwegian donor study

Averina

Hervig

Huber

et al. 2020

Transfusion Medicine

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“…The mean values of Hg in the umbilical cord blood were twice as high as in the blood of mothers ( P < 0.001). These results suggest that pregnant women and women of reproductive age should avoid even minimal contact with Hg because of its potentially adverse effects on foetal development …”

Section: Mercury Exposure and Fertility: General Aspectsmentioning

confidence: 92%

“…These results suggest that pregnant women and women of reproductive age should avoid even minimal contact with Hg because of its potentially adverse effects on foetal development. 105,106 In the past, a study revealed that prenatal exposure to Hg at 16-18 weeks of gestation might cause accumulation of the Hg in the amniotic fluid and adversely affect the health status and children's cognitive skills since the children were approximately 3 years of age. 107 As already reported above, the main source of maternal Hg vapour exposure is amalgam fillings 54 and fish.…”

Section: Mercury Exposure and Fertilit Y: General Aspectsmentioning

confidence: 99%

Mercury exposure and its effects on fertility and pregnancy outcome

Bjørklund

Chirumbolo

Dadar

et al. 2019

Basic Clin Pharma Tox

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Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce impairments in the reproductive function, cellular deformation of the Leydig cells and the seminiferous tubules, and testicular degeneration as well as abnormal menstrual cycles. Some studies investigated spontaneous abortion and complicated fertility outcome due to occupational Hg exposure. Moreover, there is a relation between inhaled Hg vapour and reproductive outcome. This MiniReview evaluates the hypothesis that exposure to Hg may increase the risk of reduced fertility, spontaneous abortion and congenital deficits or abnormalities.

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“…Meanwhile the low level of prenatal Hg exposure, through seafood consumption by the mother, was found to be positively correlated with children's language and communication skills at the age of five years [8]. Women of reproductive age and pregnant women should avoid exposure to Hg, even at low levels (4.97μg/L), because of their potentially detrimental effects on fetal development [9]. It is known that maternal exposure to HgCl 2 during pregnancy and lactation affects offspring immunity and social behavior [10].…”

Section: Introductionmentioning

confidence: 99%

Leaf ethanolic extract of Etlingera hemesphaerica Blume mitigates defects in fetal anatomy and endochondral ossification due to mercuric chloride during the post-implantation period in Mus musculus

et al. 2021

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This study aimed to investigate the effectiveness of leaf ethanolic extract of Etlingera hemisphaerica (LE3H) in reducing defects in fetal anatomy and endochondral ossification in mice induced by HgCl2 during the post-implantation period. Pregnant mice were divided into four groups, each consisting of 10 dams, and received drink and food ad libitum. The first group was administered LE3H (E1), the second one HgCl2 (E2), the third one HgCl2+LE3H (E3), and the fourth was control (E0), administered double-distilled water only. HgCl2 (5 mg/kg bw) was administrated by injection intraperitoneally on gestation day (GD)9 and LE3H (0.39 mg/g bw) was administered by gavage on GD10. The treated and control animals were killed by cervical dislocation on GD18, dissected, and the morphologically normal living fetuses (MNLF) were collected. The MNLF of E0, E1, E2, and E3 from 5 dams were fixed with Bouin solution, and observed using the free hand razor blade technique for soft tissue examination. The remaining MNLF were fixed with 96% ethanol, and then stained with Alizarin Red S and Alcian Blue for ossification examination. Index of length of ossified part (ILOP) of humerus, index of width of ossified part (IWOP) of humerus, ILOP of femur, and IWOP of femur were calculated. E2 had higher cases of anatomical defects (74,6%) than E3 (48.9%), E1 (15.0%), and E0 (0%). E2 had humerus IWOP of 0.82±0.03, which was significantly lower than that of E0 (0.89±0.04) and E1 (0.89±0.03), while that of E1 and E0 was not significantly different from each other. Meanwhile, IWOP in E3 (0.88±0.03) was significantly higher than that in E2, but not different from that in E1 and E0. Thus, LE3H mitigated defects in fetal anatomy and endochondral ossification induced by HgCl2 in mice.

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Prenatal mercury exposure and birth weight

Cited by 53 publications

References 44 publications

Environmental pollutants in blood donors: The multicentre Norwegian donor study

Environmental pollutants in blood donors: The multicentre Norwegian donor study

Mercury exposure and its effects on fertility and pregnancy outcome

Leaf ethanolic extract of Etlingera hemesphaerica Blume mitigates defects in fetal anatomy and endochondral ossification due to mercuric chloride during the post-implantation period in Mus musculus

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