Prenatal Monosodium Glutamate (MSG) Treatment Given Through the Mother's Diet Causes Behavioral Deficits in Rat Offspring

Frieder, Brina; Grimm, Veronika

doi:10.3109/00207458408985353

Cited by 26 publications

(27 citation statements)

References 17 publications

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“…MSG was shown to penetrate the placental barrier and to distribute to embryonic tissues (Frieder and Grimm, 1984;Yu et al, 1997). The results of the present work revealed that oral administration of MSG to the pregnant and lactating mother rats causes multiple changes in the histological structure of the liver for both mothers and their offspring, such observations were in accordance with Frieder and Grimm (1984) and Yu et al (1997). Our results indicated that the degree of liver histopathology induced by MSG depends upon the time of exposure.…”

Section: Discussionsupporting

confidence: 76%

“…Many studies have indicated that the application of high doses of MSG to experimental animals may cause lesions of neural structures, the retina, and a series of neuroendocrine disorders, infertility and fatty liver. MSG was shown to penetrate the placental barrier and to distribute to embryonic tissues (Frieder and Grimm, 1984;Yu et al, 1997). The results of the present work revealed that oral administration of MSG to the pregnant and lactating mother rats causes multiple changes in the histological structure of the liver for both mothers and their offspring, such observations were in accordance with Frieder and Grimm (1984) and Yu et al (1997).…”

Section: Discussionsupporting

confidence: 76%

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Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate

2016

Res. Opin. Anim. Vet. Sci.

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Monosodium glutamate (MSG) is one of the most widely used food additives as a flavour enhancer but its high dose can induce toxic effects on the liver. Melatonin is a potent antioxidant, could ameliorate acute and chronic hepatic injury. The present work was essentially designed to evaluate the ameliorating role of melatonin on the liver of pregnant female Albino rats and their pups induced by MSG. In the present research, twenty four pregnant Albino rats were divided into four groups (n=6). The control group received saline solution, the melatonin group received 100 mg/kg b.wt, MSG treated group received 400 mg/kg b.wt and ameliorative group received MSG 400 mg/kg b.wt simultaneously with melatonin 100 mg/kg b.wt. All groups were received their corresponding dose from the 4 th day of gestation till the end of weaning period. The histological study of the current work revealed that MSG could induce damage of hepatocytes with cytoplasmic vacuolation, dilation of central vein and blood sinusoids, prominent Kupffer cells, infiltration cells around the portal area, variable degree of fibrosis, and scattered fatty cells. Furthermore, MSG consumption is also associated with ultrastructural alterations that varied considerably from mild structural changes to cytoplasmic lysis and degradation of some cellular organelles. Such alterations were represented by undifferentiated cytoplasm with dispersed vacuoles, nuclear pyknosis, swollen and vacuolated mitochondria, manifested dilated rough endoplasmic reticulum, remarkable aggregation of glycogen granules and fat droplets and obvious dispersion of collagenous fibers. Supplementation of melatonin ameliorated MSG-induced histopathological and ultrastrucural changes in liver cells. Keywords: MSG, Liver, Melatonin, Histopathlology, Fibrosis, TEM, HepatocytesTo cite this article: Abd El-Fattah BM El-Beltagy, 2016. Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate. Res. Opin. Anim. Vet. Sci., 6(2): 59-68.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 76%

Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate

2016

Res. Opin. Anim. Vet. Sci.

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“…Two studies were done in Wistar rats, exposing them to MSG in their drinking water during the last 2 weeks of gestation [18,19]. In the first study [18], MSG was provided as 5 g/100 mL of water resulting in an estimated dose of 10 g/kg.…”

Section: Discussionmentioning

confidence: 99%

A Test of Dietary Monosodium Glutamate Developmental Neurotoxicity in Rats: A Reappraisal

Vorhees¹

2018

Ann Nutr Metab

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In 1979, we tested dietary monosodium glutamate (MSG) for developmental neurotoxicity in rats. The study was recently cited for establishing a No Observable Adverse Effect Level (NOAEL) for MSG as a food additive resulting in a change in the acceptable daily intake (ADI). Therefore, I re-evaluated the study [Vorhees et al.: Toxicol Appl Pharmacol 1979; 50: 267–282]. Sprague-Dawley rats were fed diets containing 0, 1.7, 3.4, or 5.1% MSG prior to conception, throughout gestation and lactation, and the same diets were fed to the offspring until 90 days of age. About 18–20 L were tested per dose with litter and sex factors in data analyses. There were 21 functional tests with 36 dependent variables and 10 body weight and histological outcomes. Of the functional tests, 4 were significant involving 6 effects. Two effects were on swimming ontogeny: one was an improvement and the other an atypical minor delay of no significance. Two effects were on active avoidance: one was a low-dose female-only extinction effect and the other a high-dose male-only acquisition effect, neither providing evidence of consistency. One was on passive avoidance, but was an improvement not a deficit. The last was on open-field rearing in the absence of its normal association with locomotion changes. Thus, it can be concluded, as was done in 1979 and by the U.S. Food and Drug Administration who sponsored the study, that there is no evidence in these data that dietary MSG is developmentally neurotoxic, hence, the study provides no basis for the establishment of a NOAEL and changing the ADI for dietary MSG.

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“…Frieder and Grimm [113,114] have demonstrated that feeding MSG to pregnant rats can lead to severe alterations in learning that only affected the male rats, again demonstrating a male preponderance of toxic effects. It has also been shown that sensitivity to glutamate increases after birth [115,116].…”

Section: Effect Of Dietary Food Additive Excitotoxinsmentioning

confidence: 99%

Immune-Glutamatergic Dysfunction as a Central Mechanism of the Autism Spectrum Disorders

Blaylock

Strunecká

2009

CMC

125

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Despite the great number of observations being made concerning cellular and the molecular dysfunctions associated with autism spectrum disorders (ASD), the basic central mechanism of these disorders has not been proposed in the major scientific literature. Our review brings evidence that most heterogeneous symptoms of ASD have a common set of events closely connected with dysregulation of glutamatergic neurotransmission in the brain with enhancement of excitatory receptor function by pro-inflammatory immune cytokines as the underlying mechanism. We suggest that environmental and dietary excitotoxins, mercury, fluoride, and aluminum can exacerbate the pathological and clinical problems by worsening excitotoxicity and by microglial priming. In addition, each has effects on cell signaling that can affect neurodevelopment and neuronal function. Our hypothesis opens the door to a number of new treatment modes, including the nutritional factors that naturally reduce excitotoxicity and brain inflammation.

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Prenatal Monosodium Glutamate (MSG) Treatment Given Through the Mother's Diet Causes Behavioral Deficits in Rat Offspring

Cited by 26 publications

References 17 publications

Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate

Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate

A Test of Dietary Monosodium Glutamate Developmental Neurotoxicity in Rats: A Reappraisal

Immune-Glutamatergic Dysfunction as a Central Mechanism of the Autism Spectrum Disorders

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