Prenatal nicotine exposure and cognitive performance in rats

Levin, Edward D.; Briggs, Sandra J.; Christopher, N. Channelle; Rose, Jed E.

doi:10.1016/0892-0362(93)90006-a

Cited by 125 publications

(83 citation statements)

References 53 publications

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“…Decreases in birth weight have been reported from animal studies using daily doses of 6 to 9 mg/kg/day nicotine via continuous infusion (Cutler et al 1996;Richardson and Tizabi 1994;Tizabi et al 2000;Vaglenova et al 2004), which produces venous serum nicotine levels higher than in most smokers. Other studies using s.c. injections or a continuous nicotine infusion that delivered a daily dose similar to or higher than that in the present study (1.5 to 5 mg/kg/day) have generally found no effect on birth weight (Fung and Lau 1989;Johns et al 1993;Levin et al 1993;Romero and Chen 2004;Shacka et al 1997;Sobrian et al 2003). Thus the reduced birth weight observed with a relatively low daily nicotine dose in the present study suggests that prenatal nicotine treatment may be more potent when administered via repeated i.v.…”

Section: Discussionmentioning

confidence: 35%

“…Numerous studies have shown a wide range of behavioral impairments in rodents prenatally exposed to nicotine, including impaired performance in the radial arm maze and Morris water maze (Levin et al 1993;Sorenson et al 1991;Yanai et al 1992), lower response and reinforcement rates under operant schedules of food delivery (Martin and Becker 1971), poorer operant discrimination performance (Martin and Becker 1971), and reduced pre-pulse inhibition of acoustic startle response . Although several animal studies have found that offspring prenatally exposed to nicotine can also exhibit hyperactivity (Ajarem and Ahmad 1998;Fung and Lau 1989;Martin and Becker 1970;Peters et al 1979;Vaglenova et al 2004), other studies have reported conflicting results (see Table 1).…”

Section: Introductionmentioning

confidence: 99%

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Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

LeSage

Gustaf

Dufek

et al. 2006

Pharmacology Biochemistry and Behavior

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Maternal tobacco use is associated with adverse developmental outcomes in offspring, including hyperactivity. Animal studies attempting to model this phenomenon have primarily used continuous s.c. nicotine infusion as the method of nicotine administration, which does not model the intermittent bolus delivery of nicotine associated with smoking in humans. The purpose of the present experiment was to examine the locomotor activity of pre-weanling offspring of pregnant rats exposed to an i.v. nicotine dosing protocol that approximates the pattern of nicotine exposure in moderate to heavy smokers. Pregnant rats were administered an i.v. bolus of 0.03 mg/kg nicotine (N=13) or saline (N=10) every 14 min for 16 hr/day, resulting in a total daily dose of 2 mg/kg (base), from gestational day 4 to delivery. Pups from each litter were tested for spontaneous locomotor activity on postnatal days (PND) 19-21 and nicotine-induced locomotor activity on PND 22. Mean birth weight was significantly lower in nicotine-exposed pups compared to controls, but body weights were equivalent between groups by the time of behavioral testing. Mean total distance traveled, vertical counts, and stereotypy counts were lower on PND 19 in nicotine-exposed pups compared to controls, but only the difference in mean stereotypy counts was statistically significant. Within session analysis revealed that both distance traveled and stereotypy were significantly decreased in nicotine-exposed pups in the first five minutes of the session on PND 19. Total time spent in the center of the field was also lower in nicotine exposed pups. Nicotine-induced increases in activity on PND 22 did not differ according to gestational exposure. These findings demonstrate that prenatal nicotine exposure in a model that mimics the pattern of nicotine exposure from cigarette smoking in humans results in offspring that exhibit low birth weight and hypoactivity in a novel environment.

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Section: Discussionmentioning

confidence: 35%

Section: Introductionmentioning

confidence: 99%

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

LeSage

Gustaf

Dufek

et al. 2006

Pharmacology Biochemistry and Behavior

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“…The poor spatial navigation observed in the present study might be due to the direct effect of nicotine on developing pups in utero, as it can cross the placental barrier and affect the developing brain (27,28). Prenatal nicotine exposure has resulted in spatial memory deficits in the Morris water maze and radial-arm maze tasks in prepubertal, adolescent, and adult rats (13,29,30). It is sug-gested that these cognitive changes may be the result of long-lasting alterations to the nicotinic and adrenergic neuro-transmitter systems following in utero exposure to nicotine (30).…”

Section: Discussionmentioning

confidence: 83%

Ascorbic Acid Ameliorates Nicotine Exposure Induced Impaired Spatial Memory Performances in Rats

et al. 2014

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“…Acetylcholine plays a critical developmental role in brain maturation (Lauder and Schambra, 1999;Weiss et al, 1998;Slotkin, 2004), initially promoting cell division, and subsequently promoting the switch from replication to differentiation (Slotkin, 1998(Slotkin, , 1999. In rodents, inappropriate stimulation of nAChRs by nicotine during prenatal development produces reductions in brain cell number, size, and surface area (Roy et al, 1998;Slotkin, 1998Slotkin, , 1999, prolonged reductions in cholinergic neural transmission (Zahalka et al, 1992;Navarro et al, 1989), and alters the subsequent response to nicotine challenge (Navarro et al, 1988;Seidler et al, 1992;Levin et al, 1993Levin et al, , 1996.…”

Section: Introductionmentioning

confidence: 99%

Visuospatial Memory Deficits Emerging During Nicotine Withdrawal in Adolescents with Prenatal Exposure to Active Maternal Smoking

Jacobsen

Slotkin

Westerveld

et al. 2005

Neuropsychopharmacol

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Active maternal smoking during pregnancy elevates the risk of cognitive deficits and tobacco smoking among offspring. Preclinical work has shown that combined prenatal and adolescent exposure to nicotine produces more pronounced hippocampal changes and greater deficits in cholinergic activity upon nicotine withdrawal than does prenatal or adolescent exposure to nicotine alone. Few prior studies have examined the potential modifying effects of gestational exposure to active maternal smoking on cognitive or brain functional response to tobacco smoking or nicotine withdrawal in adolescents. We examined visuospatial and verbal memory in 35 adolescent tobacco smokers with prenatal exposure to active maternal smoking and 26 adolescent tobacco smokers with no prenatal exposure to maternal smoking who were similar in age, educational attainment, general intelligence, and baseline plasma cotinine. Subjects were studied during ad libitum smoking and after 24 h of abstinence from smoking. A subset of subjects from each group also underwent functional magnetic resonance imaging while performing a visuospatial encoding and recognition task. Adolescent tobacco smokers with prenatal exposure experienced greater nicotine withdrawal-related deficits in immediate and delayed visuospatial memory relative to adolescent smokers with no prenatal exposure. Among adolescent smokers with prenatal exposure, nicotine withdrawal was associated with increased activation of left parahippocampal gyrus during early recognition testing of visuospatial stimuli and increased activation of bilateral hippocampus during delayed recognition testing of visuospatial stimuli. These findings extend prior preclinical work and suggest that, in human adolescent tobacco smokers, prenatal exposure to active maternal smoking is associated with alterations in medial temporal lobe function and concomitant deficits in visuospatial memory.

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Prenatal nicotine exposure and cognitive performance in rats

Cited by 125 publications

References 53 publications

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

Ascorbic Acid Ameliorates Nicotine Exposure Induced Impaired Spatial Memory Performances in Rats

Visuospatial Memory Deficits Emerging During Nicotine Withdrawal in Adolescents with Prenatal Exposure to Active Maternal Smoking

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