Prenatal O3 exposure increases the severity of OVA-induced asthma in offspring

Fu, Lingling; Yang, Xiwei; Liu, Xinai; Yu, Gongchang; Wang, Zhiping

doi:10.1016/j.ecoenv.2019.109867

Cited by 12 publications

(2 citation statements)

References 45 publications

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“…Toxicologic studies demonstrate that PM 2.5 exposure in mid-to-late prenatal windows causes an inflammatory response in the placenta and disrupts the lung epithelium ( Yue et al, 2020 ), and that mitochondrial reactive oxygen species due to PM 2.5 exposure leads to mitochondrial dysfunction in the lungs ( Wang et al, 2021 ). Animal models also indicate prenatal O 3 exposures initiate inflammatory cascades and promote oxidative stress resulting in immune dysregulation and poor airway health in offspring ( Fu et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Associations of prenatal ambient air pollution exposures with asthma in middle childhood

Hazlehurst,

Carroll,

Moore

et al. 2024

International Journal of Hygiene and Environmental Health

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Section: Discussionmentioning

confidence: 99%

Associations of prenatal ambient air pollution exposures with asthma in middle childhood

Hazlehurst,

Carroll,

Moore

et al. 2024

International Journal of Hygiene and Environmental Health

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“…A further study conducted in Canada reported an association between NO 2 and PM 2.5 exposure in the second trimester with an increased risk of asthma development in children [ 91 ]. A study conducted on mice also revealed that O 3 exposure during the gestation period could lead to airway inflammation and, particularly, it has been shown to act through the imbalance of the Th1/Th2 differentiation in the offspring, increasing the severity of asthma [ 92 ]. Kannan and colleagues [ 93 ] demonstrated that inhaled pollutants by pregnant mothers can decrease the nutrient/oxygen supply, through inflammatory and immune reactions of the mother, or can act directly on the fetus, crossing the placenta.…”

Section: Air Pollution and The Immune Systemmentioning

confidence: 99%

Air Pollution: Possible Interaction between the Immune and Nervous System?

Serafini

Maddalon

Iulini

et al. 2022

IJERPH

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Exposure to environmental pollutants is a serious and common public health concern associated with growing morbidity and mortality worldwide, as well as economic burden. In recent years, the toxic effects associated with air pollution have been intensively studied, with a particular focus on the lung and cardiovascular system, mainly associated with particulate matter exposure. However, epidemiological and mechanistic studies suggest that air pollution can also influence skin integrity and may have a significant adverse impact on the immune and nervous system. Air pollution exposure already starts in utero before birth, potentially causing delayed chronic diseases arising later in life. There are, indeed, time windows during the life of individuals who are more susceptible to air pollution exposure, which may result in more severe outcomes. In this review paper, we provide an overview of findings that have established the effects of air pollutants on the immune and nervous system, and speculate on the possible interaction between them, based on mechanistic data.

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Prenatal Origins of Obstructive Airway Disease: Starting on the Wrong Trajectory?

Wang,

James,

Donovan

et al. 2024

Comprehensive Physiology

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From the results of well‐performed population health studies, we now have excellent data demonstrating that deficits in adult lung function may be present early in life, possibly as a result of developmental disorders, incurring a lifelong risk of obstructive airway diseases such as asthma and chronic obstructive pulmonary disease. Suboptimal fetal development results in intrauterine growth restriction and low birth weight at term (an outcome distinct from preterm complications), which are associated with subsequent obstructive disease. Numerous prenatal exposures and disorders compromise fetal development and these are summarized herein. Various physiological, structural, and mechanical abnormalities may result from prenatal disruption, including changes to airway smooth muscle structure–function, goblet cell biology, airway stiffness, geometry of the bronchial tree, lung parenchymal structure and mechanics, respiratory skeletal muscle contraction, and pulmonary inflammation. The literature therefore supports the need for early life intervention to prevent or correct growth defects, which may include simple nutritional or antioxidant therapy. © 2024 American Physiological Society. Compr Physiol 14:5729‐5762, 2024.

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Prenatal O3 exposure increases the severity of OVA-induced asthma in offspring

Cited by 12 publications

References 45 publications

Associations of prenatal ambient air pollution exposures with asthma in middle childhood

Associations of prenatal ambient air pollution exposures with asthma in middle childhood

Air Pollution: Possible Interaction between the Immune and Nervous System?

Prenatal Origins of Obstructive Airway Disease: Starting on the Wrong Trajectory?

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