Prenatal origins of temperamental reactivity in early infancy

DiPietro, Janet A.; Ghera, Melissa M.; Costigan, Kathleen A.

doi:10.1016/j.earlhumdev.2008.01.004

Cited by 58 publications

(48 citation statements)

References 33 publications

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“…Furthermore, most of the 10 foods richest in zinc—seafood, lamb, wheat germ, spinach, pumpkin seeds, mushrooms—are uncommon for urban teenagers or those in poverty [6,44]. Emerging data show continuity between fetal and infant development [28,45], and fetal ANS features predicting infant neurobehavioral outcomes [28,46]. Thus, these results showing effects of deficient zinc and HRV may have implications for children’s long-term outcomes.…”

Section: Discussionmentioning

confidence: 99%

Deficient maternal zinc intake—but not folate—is associated with lower fetal heart rate variability

Spann

Smerling

Gustafsson

et al. 2015

Early Human Development

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Objective Few studies of maternal prenatal diet and child development examine micronutrient status in relation to fetal assessment. Methods Twenty-four-hour dietary recall of zinc and folate and 20min of fetal heart rate were collected from 3rd trimester pregnant adolescents. Results Deficient zinc was associated with less fetal heart rate variability. Deficient folate had no associations with HRV. Neither deficient zinc nor deficient folate was related to fetal heart rate. Conclusions These findings, from naturalistic observation, are consistent with emerging data on prenatal zinc supplementation using a randomized control design. Practical Implication Taken together, the findings suggest that maternal prenatal zinc intake is an important and novel factor for understanding child ANS development.

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Section: Discussionmentioning

confidence: 99%

Deficient maternal zinc intake—but not folate—is associated with lower fetal heart rate variability

Spann

Smerling

Gustafsson

et al. 2015

Early Human Development

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“…High levels of DNA methylation of NR3c1 may be related to greater neuroendocrine reactivity (Conradt et al, 2015; Oberlander et al, 2008) and a more reactive phenotype in infancy (Conradt et al, 2015). This reactive phenotype may elicit more attention from caregivers (DiPietro, Ghera, & Costigan, 2008; Scheper-Hughes, 1985) and a greater likelihood that the infants’ needs for food and comfort are being met. This phenotype is generally not considered desirable in Western society.…”

Section: Fetal Programming Models: a Need For Testable Hypotheses Thamentioning

confidence: 99%

Incorporating epigenetic mechanisms to advance fetal programming theories

et al. 2018

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Decades of fetal programming research indicates that we may be able to map the origins of many physical, psychological, and medical variations and morbidities before the birth of the child. While great strides have been made in identifying associations between prenatal insults, such as undernutrition or psychosocial stress, and negative developmental outcomes, far less is known about how adaptive responses to adversity regulate the developing phenotype to match stressful conditions. As the application of epigenetic methods to human behavior has exploded in the last decade, research has begun to shed light on the role of epigenetic mechanisms in explaining how prenatal conditions shape later susceptibilities to mental and physical health problems. In this review we describe and attempt to integrate two dominant fetal programming models: the cumulative stress model (a disease-focused approach) and the match-mismatch model (an evolutionary-developmental approach). In conjunction with biological sensitivity to context theory, we employ these two models to generate new hypotheses regarding epigenetic mechanisms through which prenatal and postnatal experiences program child stress reactivity and, in turn, promote development of adaptive versus maladaptive phenotypic outcomes. We conclude by outlining priority questions and future directions for the fetal programming field.

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“…Orienting responses and individual differences in reaction tendencies are present from birth (DiPietro et al, 2008). The earlymaturing nature of the automatic mode corresponds with the early maturation of the underlying brain networks linked to its functioning.…”

Section: Developmental Perspectivesmentioning

confidence: 99%

Behavioral Inhibition and Developmental Risk: A Dual-Processing Perspective

Henderson

Pine

Fox

2014

Neuropsychopharmacol

180

184

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Behavioral inhibition (BI) is an early-appearing temperament characterized by strong reactions to novelty. BI shows a good deal of stability over childhood and significantly increases the risk for later diagnosis of social anxiety disorder (SAD). Despite these general patterns, many children with high BI do not go on to develop clinical, or even subclinical, anxiety problems. Therefore, understanding the cognitive and neural bases of individual differences in developmental risk and resilience is of great importance. The present review is focused on the relation of BI to two types of information processing: automatic (novelty detection, attention biases to threat, and incentive processing) and controlled (attention shifting and inhibitory control). We propose three hypothetical models (Top-Down Model of Control; Risk Potentiation Model of Control; and Overgeneralized Control Model) linking these processes to variability in developmental outcomes for BI children. We argue that early BI is associated with an early bias to quickly and preferentially process information associated with motivationally salient cues. When this bias is strong and stable across development, the risk for SAD is increased. Later in development, children with a history of BI tend to display normative levels of performance on controlled attention tasks, but they demonstrate exaggerated neural responses in order to do so, which may further potentiate risk for anxiety-related problems. We conclude by discussing the reviewed studies with reference to the hypothetical models and make suggestions regarding future research and implications for treatment.

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Prenatal origins of temperamental reactivity in early infancy

Abstract: These results support the presumption that early postnatal temperamental characteristics emerge during the prenatal period.

Cited by 58 publications

References 33 publications

Deficient maternal zinc intake—but not folate—is associated with lower fetal heart rate variability

Deficient maternal zinc intake—but not folate—is associated with lower fetal heart rate variability

Incorporating epigenetic mechanisms to advance fetal programming theories

Behavioral Inhibition and Developmental Risk: A Dual-Processing Perspective

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