Prenatal predictors of chronic lung disease in very preterm infants

Henderson‐Smart, David J; Hutchinson, Jolie; Donoghue, Deborah A; Evans, Nicholas J.; Simpson, Judy M.; Wright, Ian

doi:10.1136/adc.2005.072264

Cited by 76 publications

(64 citation statements)

References 33 publications

(18 reference statements)

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“…These were not the expected results and could help explain the contradictory findings in the literature. Indeed, previous studies found a positive association 21,23,33 or no association 10,25,34 between placentamediated complications and BPD. However, a few studies distinguished between preeclamptic women with and without FGR.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies found an association with BPD, [21][22][23] but others did not. 10,24,25 Most studies focused on maternal disorders but did not look at fetal consequences of placenta-mediated pregnancy complications.…”

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confidence: 99%

“…5 BPD is strongly associated with low gestational age at birth [6][7][8] and low birth weight for gestational age. [9][10][11][12] Mechanical ventilation, oxygen therapy, patent ductus arteriosus, neonatal infection, male gender, and genetic factors are other risk factors. 10,13,14 Moreover, placentamediated pregnancy complications were recently suggested to be associated with BPD.…”

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confidence: 99%

“…[9][10][11][12] Mechanical ventilation, oxygen therapy, patent ductus arteriosus, neonatal infection, male gender, and genetic factors are other risk factors. 10,13,14 Moreover, placentamediated pregnancy complications were recently suggested to be associated with BPD. These include maternal disorders resulting from placental dysfunction such as gestational hypertension and preeclampsia and fetal disorders such as fetal growth restriction (FGR), which can occur without maternal hypertension.…”

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confidence: 99%

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Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study

et al. 2016

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OBJECTIVE: To investigate the relationship between placenta-mediated pregnancy complications and bronchopulmonary dysplasia (BPD) in very preterm infants.METHODS: National prospective population-based cohort study including 2697 singletons born before 32 weeks' gestation. The main outcome measure was moderate to severe BPD. Three groups of placenta-mediated pregnancy complications were compared with no placenta-mediated complications: maternal disorders only (gestational hypertension or preeclampsia), fetal disorders only (antenatal growth restriction), and both maternal and fetal disorders. RESULTS:Moderate to severe BPD rates were 8% in infants from pregnancies with maternal disorders, 15% from both maternal and fetal disorders, 23% from fetal disorders only, and 9% in the control group (P < .001). When we adjusted for gestational age, the risk of moderate to severe BPD was greater in the groups with fetal disorders only (odds ratio [OR] = 6.6; 95% confidence interval [CI], 4.1-10.7), with maternal and fetal disorders (OR = 3.7; 95% CI, 2.5-5.5), and with maternal disorders only (OR = 1.7; 95% CI, 1.0-2.7) than in the control group. When we also controlled for birth weight, the relationship remained in groups with fetal disorders only (OR = 4.2; 95% CI, 2.1-8.6) and with maternal and fetal disorders (OR = 2.1; 95% CI, 1.1-3.9).CONCLUSIONS: Placenta-mediated pregnancy complications with fetal consequences are associated with moderate to severe BPD in very preterm infants independently of gestational age and birth weight, but isolated maternal hypertensive disorders are not. Fetal growth restriction, more than birth weight, could predispose to impaired lung development.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study

et al. 2016

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“…La mayor frecuencia de DBP en el sexo masculino sería otra señal que factores genéticos estarían involucrados en la patogenia de la DBP 11,51 . La forma por la cual el género masculino predispondría al desarrollo de DBP aún no esta claramente precisada.…”

Section: Factores Genéticosunclassified

Actualización en Presentación y Patogénesis de la Displasia Broncopulmonar

2009

Rev. chil. pediatr.

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Update on Presentation and Pathogenesis of Brochopulmonary DysplasiaBronchopulmonary dysplasia (BPD) remains as the most frequent chronic lung disease seen among babies with very low birth weight, contributing to their morbidity and mortality. An increase in the survival of very immature babies due to improvement in pre and post natal care, has resulted in an increase in the number of newborns with BDP, although there have been no changes in the actual incidence of the disease. Objective: To describe the evolution of DBP in recent decades, the current definition, and to describe and analyze the risk factors involved in the pathogenesis of this disease. Until a few years ago, the terms BPD and chronic lung disease were used as synonyms. After the workshop sponsored by the National Institute of Health in the United States in 2001, it was recommended that the term BPD be used to describe the pulmonary sequelae of immature babies. Classic severe BPD, as described by Northway et al over forty years ago, has evolved into milder forms of chronic pulmonary damage, the so-called "new BPD", characterized by impairment of alveolarización and vascularization of the immature lung in response to multiple injuries. BPD is a multifactorial disease where major risk factors are related to pulmonary immaturity, hyperoxia, baro/volutrauma, as well as inflamation and infection. Genetic susceptibility has recently been shown to be another important risk factor. Conclusion: Bronchopulmonary Dysplasia continues to be the most frequent sequelae affecting low birth weight infants. In the past four decades, the disease has been better defined, and new pathogenetic risk factors have been established. RESUMENLa Displasia Broncopulmonar (DBP) continúa siendo la enfermedad pulmonar crónica más frecuente que afecta al recién nacido de muy bajo peso, contribuyendo a su morbilidad y mortalidad. El aumento en la sobrevida de los recién nacidos muy inmaduros, debido a la mejoría en el cuidado pre y post natal, ha aumentado el número de recién nacidos con displasia, sin cambios en su incidencia. El objetivo de esta revisión es representar los cambios en la presentación clínica de la DBP en las últimas décadas y describir ACTUALIDAD CLINICAL OVERVIEW Rev Chil Pediatr 2009; 80 (3): 213-224

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Mechanisms of Sex Disparities in Cardiovascular Function and Remodeling

Chaudhari

Cushen

Osikoya

et al. 2018

Comprehensive Physiology

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Epidemiological studies demonstrate disparities between men and women in cardiovascular disease prevalence, clinical symptoms, treatments, and outcomes. Enrollment of women in clinical trials is lower than men, and experimental studies investigating molecular mechanisms and efficacy of certain therapeutics in cardiovascular disease have been primarily conducted in male animals. These practices bias data interpretation and limit the implication of research findings in female clinical populations. This review will focus on the biological origins of sex differences in cardiovascular physiology, health, and disease, with an emphasis on the sex hormones, estrogen and testosterone. First, we will briefly discuss epidemiological evidence of sex disparities in cardiovascular disease prevalence and clinical manifestation. Second, we will describe studies suggesting sexual dimorphism in normal cardiovascular function from fetal life to older age. Third, we will summarize and critically discuss the current literature regarding the molecular mechanisms underlying the effects of estrogens and androgens on cardiac and vascular physiology and the contribution of these hormones to sex differences in cardiovascular disease. Fourth, we will present cardiovascular disease risk factors that are positively associated with the female sex, and thus, contributing to increased cardiovascular risk in women. We conclude that inclusion of both men and women in the investigation of the role of estrogens and androgens in cardiovascular physiology will advance our understanding of the mechanisms underlying sex differences in cardiovascular disease. In addition, investigating the role of sex‐specific factors in the development of cardiovascular disease will reduce sex and gender disparities in the treatment and diagnosis of cardiovascular disease. © 2019 American Physiological Society. Compr Physiol 9:375‐411, 2019.

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Prenatal predictors of chronic lung disease in very preterm infants

Cited by 76 publications

References 33 publications

Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study

Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study

Actualización en Presentación y Patogénesis de la Displasia Broncopulmonar

Mechanisms of Sex Disparities in Cardiovascular Function and Remodeling

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