Prenatal Protein Malnutrition and Postnatal Brain Function<sup>a</sup>

Tonkiss, John; Galler, Janina R.; Morgane, Peter J.; Bronzino, Joseph D.; Austin-LaFrance, R.J.

doi:10.1111/j.1749-6632.1993.tb26124.x

Cited by 77 publications

(42 citation statements)

References 40 publications

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“…Prenatal protein malnutrition has been demonstrated to alter diverse anatomical and physiological parameters in the hippocampal formation and to affect performance on hippocampally mediated behavioral tasks Tonkiss et al, 1993;Galler et al, 1996). These effects persist to adulthood even following full dietary rehabilitation of the pups at parturition.…”

Section: Introductionmentioning

confidence: 97%

Electrophysiological properties of rat hippocampal principal cells are unaltered by prenatal protein malnutrition

1998

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Section: Introductionmentioning

confidence: 97%

Electrophysiological properties of rat hippocampal principal cells are unaltered by prenatal protein malnutrition

1998

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“…Our group has attempted to understand the consequences of malnutrition on the development of the brain in a rat model of prenatal protein malnutrition which exposes rats in utero to a low (6%) casein diet Morgane et al, 2002;Tonkiss et al, 1993). We have found that prenatal protein malnutrition, though affecting broad areas of the brain, particularly impacts the limbic formation (Morgane et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Stress-induced changes in extracellular dopamine and serotonin in the medial prefrontal cortex and dorsal hippocampus of prenatally malnourished rats

et al. 2007

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Prenatal protein malnutrition continues to be a significant problem in the world today. Exposure to prenatal protein malnutrition increases the risk of a number of neuropsychiatric disorders in adulthood including depression, schizophrenia and attentional deficit disorder. In the present experiment we have examined the effects of stress on extracellular serotonin (5-HT) and dopamine in the medial prefrontal cortex and dorsal hippocampus of rats exposed in utero to protein malnutrition. The medial prefrontal cortex and dorsal hippocampus were chosen as two limbic forebrain regions involved in learning and memory, attention and the stress response. Extracellular 5-HT and dopamine were determined in the medial prefrontal cortex and dorsal hippocampus of adult male Sprague-Dawley rats using dual probe in vivo microdialysis. Basal extracellular 5-HT did not differ between malnourished and well-nourished controls in either the medial prefrontal cortex or the dorsal hippocampus. Basal extracellular dopamine was significantly decreased in the medial prefrontal cortex of malnourished animals. Restraint stress (20 m) produced a significant rise in extracellular dopamine in the medial prefrontal cortex of well-nourished rats but did not alter release in malnourished rats. In malnourished rats, stress produced an increase in 5-HT in the hippocampus, whereas stress produced a decrease in 5-HT in the hippocampus of well-nourished rats. These data demonstrate that prenatal protein malnutrition alters dopaminergic neurotransmission in the medial prefrontal cortex as well as altering the dopaminergic and serotonergic response to stress. These changes may provide part of the bases for alterations in malnourished animals' response to stress.

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“…(Galler et al, 1996;Scrimshaw, 1998;Strupp & Levitsky, 1995;Tonkiss, Galler, Morgane, Bronzino, & Austin-Lafrance, 1993). Besides, literature reports show that PEM causes neurophysiological changes in the visual system (VS) of rats, for example: (1) retinal and lens damages (Bonavolonta, Ferrante, & Rosati, 1989;Bonavolonte, Ferrante, Terracciano, & Vecchione, 1991), (2) deficit in number and size-frequency distribution of the optic nerve fiber (Bedi & Warren, 1983), (3) decrease in the synapsesto-neuron ratio (Bedi & Warren, 1983;Bedi, Massey, & Smart, 1989;Gundappa & Desiraju, 1988) and structure changes in the pyramidal cells of the visual cortex (Díaz-Cintra, Cintra, Ortega, Kemper, & Morgane, 1990).…”

Section: Introductionmentioning

confidence: 99%

Contrast sensitivity function of sine-wave gratings in children with acute malnutrition.

Santos¹,

Alencar²,

Dias³

2009

Psychology & Neuroscience

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The aim of this study was to determine the contrast sensitivity curves of sine-wave gratings with spatial frequencies of 0.25, 1.0, 2.0 and 8.0 cycles per degree (cpd) of visual angle in 16 female subjects aged 7 to 9 years old, eight well-nourished and eight with acute protein-energy malnutrition (PEM). All participants had normal visual acuity and were free of identifiable ocular illness. Contrast threshold was measured using a temporal two-alternative forced-choice psychophysical method, at a distance of 150 cm of the stimuli, binocularly, with mean luminance of 40.1 cd/m2. We detected a general decline in contrast sensitivity for children with acute malnutrition at all spatial frequencies compared to well-nourished children. The malnourished group needed in average 1.37 times more contrast to detect the stimulus in comparison with the well-nourished one. Differences between the groups were statistically significant at all spatial frequencies (p < .001). These results suggest that acute PEM changes the visual perception for sine-wave gratings

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Prenatal Protein Malnutrition and Postnatal Brain Function^a

Cited by 77 publications

References 40 publications

Electrophysiological properties of rat hippocampal principal cells are unaltered by prenatal protein malnutrition

Electrophysiological properties of rat hippocampal principal cells are unaltered by prenatal protein malnutrition

Stress-induced changes in extracellular dopamine and serotonin in the medial prefrontal cortex and dorsal hippocampus of prenatally malnourished rats

Contrast sensitivity function of sine-wave gratings in children with acute malnutrition.

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Prenatal Protein Malnutrition and Postnatal Brain Functiona

Cited by 77 publications

References 40 publications

Electrophysiological properties of rat hippocampal principal cells are unaltered by prenatal protein malnutrition

Electrophysiological properties of rat hippocampal principal cells are unaltered by prenatal protein malnutrition

Stress-induced changes in extracellular dopamine and serotonin in the medial prefrontal cortex and dorsal hippocampus of prenatally malnourished rats

Contrast sensitivity function of sine-wave gratings in children with acute malnutrition.

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Prenatal Protein Malnutrition and Postnatal Brain Function^a