Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds—a pilot study in sheep

Saadai, Payam; Nout, Yvette S.; Encinas, José Luis; Wang, Aijun; Downing, Timothy L.; Beattie, Michael S.; Bresnahan, Jacqueline C.; Li, Song; Farmer, Diana L.

doi:10.1016/j.jpedsurg.2011.09.014

Cited by 38 publications

(29 citation statements)

References 21 publications

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“…Several works demonstrated that electrospun fibrous membranes showed a minimized foreign body reaction in animal models in vivo, such as rat [15], rabbit [16] and sheep [17]. From our results, all membranes made of the blended polymers showed mild foreign body reaction, and the membrane with PCL had a lower inflammation than others, due to the less acidic products of degradation.…”

Section: Discussionsupporting

confidence: 54%

Bone regeneration potential of sub-microfibrous membranes with osteogenic induction of rBMSC for tissue engineering

Rhee¹,

Oh²,

Lim³

et al. 2017

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 54%

Bone regeneration potential of sub-microfibrous membranes with osteogenic induction of rBMSC for tissue engineering

Rhee¹,

Oh²,

Lim³

et al. 2017

Trop. J. Pharm Res

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“…Previously we have explored the use of natural materials [30] and synthetic scaffolds with and without drug-delivery for spinal cord regeneration [31, 32]. Electrospun nanofibrous patches, with rolipram immobilized to the surface via hydrophobic adsorption, showed anatomical as well as functional improvements after a T9-T11 level SCI.…”

Section: Introductionmentioning

confidence: 99%

Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair

Downing

Wang

Yan

et al. 2012

Journal of Controlled Release

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Spinal cord injury (SCI) remains a major challenge for regenerative medicine. Following SCI, axon growth inhibitors and other inflammatory responses prevent functional recovery. Previous studies have demonstrated that rolipram, an anti-inflammatory and cyclic adenosine monophosphate preserving small molecule, improves spinal cord regeneration when delivered systemically. However, more recent studies showed that rolipram has some adverse effects in spinal cord repair. Here, we developed a drug-delivery platform for the local delivery of rolipram into the spinal cord. The potential of drug-eluting microfibrous patches for continuous delivery of high and low-dose rolipram concentrations was characterized in vitro. Following C5 hemisections, athymic rats were treated with patches loaded with low and high doses of rolipram. In general, animals treated with low-dose rolipram experienced greater functional and anatomical recovery relative to all other groups. Outcomes from the high-dose rolipram treatment were similar to those with no treatment. In addition, high-dose treated animals experienced reduced survival rates suggesting that systemic toxicity was reached. With the ability to control the release of drug dosage locally within the spinal cord, drug-eluting microfibrous patches demonstrate the importance of appropriate local release-kinetics of rolipram, proving their usefulness as a therapeutic platform for the study and repair of SCI.

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“…Other groups are exploring the use of biomaterials such as gelatin microspheres and nanofibrous scaffolds as a means to maximize the unique benefits of prenatal MMC closure. 40,41 This research is preliminary, but supports further study into the benefits of a multifaceted approach to MMC repair. Finally, due to the maternal morbidity of open fetal surgery, less invasive methods of fetal MMC treatment continue to be investigated.…”

Section: New Directionsmentioning

confidence: 54%

Fetal Surgery for Myelomeningocele

Hirose¹,

Farmer²

2012

Clinics in Perinatology

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Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds—a pilot study in sheep

Cited by 38 publications

References 21 publications

Bone regeneration potential of sub-microfibrous membranes with osteogenic induction of rBMSC for tissue engineering

Bone regeneration potential of sub-microfibrous membranes with osteogenic induction of rBMSC for tissue engineering

Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair

Fetal Surgery for Myelomeningocele

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