Prenatal stress alters the developmental pattern of behavioral indices of sexual maturation and copulation in male rats

Hernández‐Arteaga, Enrique; Hernández‐González, Marisela; Rentería, Mayra Liliana Ramírez; Almanza-Sepúlveda, Mayra Linné; Guevara, Miguel Ángel; Silva, Marcela Arteaga; Jaime, Herlinda Bonilla

doi:10.1016/j.physbeh.2016.05.008

Cited by 21 publications

(15 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, prenatal metabolic stress (maternal undernutrition) and neonatal immune stress (the injection of lipopolysaccharides [LPS]) delayed PS in male rats and VO in female rats, indicating that these stressors disturb sexual maturation in both sexes. Similarly, subjecting mothers to psychological stress during pregnancy delayed PS in male offspring in rats, indicating that subjecting mothers to prenatal stress disturbs sexual maturation in male offspring . However, as for neonatal psychological stress, MS delayed PS in male rats in a previous study, but advanced it in the present study.…”

Section: Discussioncontrasting

confidence: 56%

“…Similarly, subjecting mothers to psychological stress during pregnancy delayed PS in male offspring in rats, indicating that subjecting mothers to prenatal stress disturbs sexual maturation in male offspring. 19 However, as for neonatal psychological stress, MS delayed PS in male rats in a previous study, 15 but advanced it in the present study. This is the first report that male rat's sexual maturation was accelerated.…”

Section: Discussionsupporting

confidence: 51%

See 1 more Smart Citation

The influence of psychological stress in early life on sexual maturation and sexual behavior in male and female rats

Yano

Matsuzaki

Iwasa

et al. 2019

Reprod Medicine & Biology

View full text Add to dashboard Cite

Purpose We studied the influence of psychological stress during the early neonatal period on sexual maturation and sexual behavior in rats. Methods Neonatal male and female rats were divided into control (C) and maternal separation (MS) groups (n = 20‐24 per group). The pups in the MS groups were placed in isolation cages for 240 minutes/d from postnatal days 2‐11. Vaginal opening (VO) in females and preputial separation (PS) in males (indicators of sexual maturation) were monitored, as was the estrous cycle in females. Thereafter, sexual behavior was monitored twice at 13 and 15 weeks of age. Results As for sexual maturation, the onset of PS occurred significantly earlier in the MS group than in the C group, whereas the onset of VO did not differ between the groups. The length of the estrous cycle did not differ between the groups. The frequencies of sexual behaviors did not differ between the groups in either sex. Conclusions In conclusion, early‐life psychological stress induced by MS advanced sexual maturation in male rats, whereas it did not affect sexual maturation in female rats. On the other hand, early‐life psychological stress might not affect sexual behavior in adulthood in either sex.

show abstract

Section: Discussioncontrasting

confidence: 56%

Section: Discussionsupporting

confidence: 51%

The influence of psychological stress in early life on sexual maturation and sexual behavior in male and female rats

Yano

Matsuzaki

Iwasa

et al. 2019

Reprod Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…Maternal separation during the period from PND2-10, which is a model of psychological stress, also prolonged the time to the first mount and intromission events, and reduced the number of ejaculation events in male rats (Rhees et al, 2001;Gerardin et al, 2005). Similarly, in another rat study maternal restraint stress during gestation prolonged the time to the first mounting/intromission events, reduced the number of ejaculation events, and suppressed the serum T level in male offspring (Gerardin et al, 2005;Pereira et al, 2006;Hernández-Arteaga et al, 2016). These studies indicated that psychological or immune stress in the prenatal or early neonatal period can suppress sexual behavior in adulthood in male rats.…”

Section: Discussionmentioning

confidence: 92%

“…This agrees with the study by Walker A et al, in which LPS injections were administered on PND3 and 5 (Walker et al, 2011). In addition, experiencing other kinds of stress, such as undernutrition, in the prenatal or early neonatal period can also delay sexual maturation in male rats (Chernoff et al, 2009; Hernández‐Arteaga et al, 2016). Female rats that were subjected to prenatal undernutrition also exhibited delayed sexual maturation (Iwasa et al, 2010a, b; Castellano et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

The reduction in sexual behavior induced by neonatal immune stress is not related to androgen levels in male rats

Mayila

Matsuzaki

Iwasa

et al. 2018

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

In male rats, immune stress in the early neonatal period delayed sexual maturation, reduced sexual behavior, suppressed the serum T concentration, and downregulated the hypothalamic mRNA expression levels of GnRH and the PR in adulthood. The delayed sexual maturation was presumed to have been caused by the reduction in the serum T concentration. However, the rats that experienced neonatal stress exhibited reduced sexual behavior irrespective of their serum T concentrations.

show abstract

“…(Rhees and Fleming, 1981), immobilization stress in rats once per day for 2h from 14.5 to 21.5 p.c. (Hernandez-Arteaga et al, 2016), various stress (light, heat, noise, handling) during the last week of gestation in mice (Meek et al, 2006) or overcrowding from days 12.5-17.5 p.c. in mice (Harvey and Chevins, 1984).…”

Section: Discussionmentioning

confidence: 99%

Injections to pregnant mice produce prenatal stress that affects aggressive behavior in their adult male offspring

Ogrizek

Grgurevic

Snoj

et al. 2018

Hormones and Behavior

View full text Add to dashboard Cite

Maternal stress could reprogram the developing fetal nervous system. A common target of maternal glucocorticoids is fetal neuro-endocrine axis. In the present study, pregnant mice were exposed to stress by injection and their male offspring were tested for sexual and aggressive behaviors in adult life. Three groups of pregnant mice were exposed to stress by sham syringe injection. The first group was injected on days 13, 14, and 15 p.c., the second group was injected on days 17 and 18 p.c., and the third group was injected daily from days 13 to 18 p.c. while control mice were not injected. Male offspring that were exposed to stress on days 13-18 p.c. and 17-18 p.c. were less aggressive and had lower blood testosterone levels in comparison to the control group. In male sexual behavior, there were no statistically significant differences between the groups. Body weight differed significantly with groups injected on days 13-18 p.c. and 13-15 p.c. having significantly higher body weight in adult life than the other two groups. After behavioral testing, brains were processed for immunohistochemical staining with antibodies against vasopressin (AVP) and calbindin (CALB). The expression of AVP and CALB in the lateral septum and in the preoptic area, respectively, did not differ between groups, suggesting that these two masculinization markers were not affected by prenatal stress. Present study therefore shows that even presumably mild and short prenatal stress weakens aggressive behavior of adult male mice, possibly due to reduced testosterone levels in blood.

show abstract

Prenatal stress alters the developmental pattern of behavioral indices of sexual maturation and copulation in male rats

Cited by 21 publications

References 54 publications

The influence of psychological stress in early life on sexual maturation and sexual behavior in male and female rats

The influence of psychological stress in early life on sexual maturation and sexual behavior in male and female rats

The reduction in sexual behavior induced by neonatal immune stress is not related to androgen levels in male rats

Injections to pregnant mice produce prenatal stress that affects aggressive behavior in their adult male offspring

Contact Info

Product

Resources

About