Prenatal Stress and Child Health: Immune Models and Mechanisms

O’Connor, Thomas G.; Sefair, Ana Vallejo

doi:10.1007/978-3-030-60159-1_7

Cited by 2 publications

(1 citation statement)

References 221 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…underlying these vulnerabilities include the dysregulation of the developing fetal and infant hypothalamic-pituitary-adrenocortical (HPA) axis and immune system, thought to engender postnatal airway in ammation while hindering airway and lung growth through epigenetic modi cations and placental nutrition 7 . Perhaps due to its established associations with these prenatal exposures and physiological mechanisms, prenatal maternal stress (PNMS) has become increasingly central to the narrative of the fetal origins of asthma, as demonstrated by several recent reviews [8][9][10][11] .…”

mentioning

confidence: 99%

Prenatal Maternal Stress and Pediatric Asthma Across Development: Adolescent Female-Specific Vulnerability

Pike,

Engel,

Lipner

et al. 2023

Child Psychiatry Hum Dev

View full text Add to dashboard Cite

Prenatal maternal stress (PNMS) is linked to physical sequelae in offspring, including childhood asthma.This study sought to examine the roles of objective and subjective PNMS in the development of asthma at offspring ages 5 and 15. The sample included 815 mother-child dyads from the Mater Misericordiae Mothers' Hospital-University of Queensland Study of Pregnancy. PNMS was measured via retrospective self-report during pregnancy and 3-5 days after birth. Postnatal maternal stress was measured at offspring age 5. Objective PNMS was associated with elevated asthma risk at age 5 (OR = 1.21, 95% CI = 1.00, 1.45, p = 0.05), albeit not above concurrent postnatal stress. Sex moderated the association between PNMS and asthma at age 15, controlling for postnatal stress. Sex strati ed analyses revealed a positive association between objective PNMS and age 15 asthma in females, but not males. Results provide evidence that PNMS may impact asthma outcomes in adolescence.

show abstract

mentioning

confidence: 99%

Prenatal Maternal Stress and Pediatric Asthma Across Development: Adolescent Female-Specific Vulnerability

Pike,

Engel,

Lipner

et al. 2023

Child Psychiatry Hum Dev

View full text Add to dashboard Cite

show abstract

Prenatal Maternal Stress and Pediatric Asthma Across Development: Adolescent Female-Specific Vulnerability

Pike

Engel

Lipner

et al. 2022

Preprint

View full text Add to dashboard Cite

Prenatal maternal stress (PNMS) is linked to physical sequelae in offspring, including childhood asthma. This study sought to examine the roles of objective and subjective PNMS in the development of asthma at offspring ages 5 and 15. The sample included 815 mother-child dyads from the Mater Misericordiae Mothers’ Hospital-University of Queensland Study of Pregnancy. PNMS was measured via retrospective self-report during pregnancy and 3–5 days after birth. Postnatal maternal stress was measured at offspring age 5. Objective PNMS was associated with elevated asthma risk at age 5 (OR = 1.21, 95% CI = 1.00, 1.45, p = 0.05), albeit not above concurrent postnatal stress. Sex moderated the association between PNMS and asthma at age 15, controlling for postnatal stress. Sex stratified analyses revealed a positive association between objective PNMS and age 15 asthma in females, but not males. Results provide evidence that PNMS may impact asthma outcomes in adolescence.

show abstract

Prenatal Stress and Child Health: Immune Models and Mechanisms

Cited by 2 publications

References 221 publications

Prenatal Maternal Stress and Pediatric Asthma Across Development: Adolescent Female-Specific Vulnerability

Prenatal Maternal Stress and Pediatric Asthma Across Development: Adolescent Female-Specific Vulnerability

Prenatal Maternal Stress and Pediatric Asthma Across Development: Adolescent Female-Specific Vulnerability

Contact Info

Product

Resources

About