2023
DOI: 10.21203/rs.3.rs-3303973/v1
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Prenatal stress increases corticosterone levels in offspring by impairing placental glucocorticoid barrier function

Hong-ya Liu,
Rui Wang,
Jia-shu Zhu
et al.

Abstract: Background: Exposure to high cortisol levels in fetus of prenatal stress (PS) has adverse effects on growth, which is related to placental glucocorticoid (GC) barrier. DNA methylation is a potential prenatal planning mechanism in embryonic stage, however, the epigenetic regulation of placental GC barrier related genes on the PS resulting higher GC is unclear. This study was to test the hypothesis that PS would elevate cortisol which was associated with GC-related placenta genes (11β-HSD2, P-gp, NR3C1, and FKBP… Show more

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