Prenatal thrombosis of the ductus arteriosus

Abstract

Spontaneous thrombus in the ductus arteriosus, without associated ductal aneurysm, is a rare condition. We report successful management with clinical and echocardiographic follow-up in a newborn with prenatal diagnosis.

Post-natal diagnosis and catheter-based management of premature fetal ductal closure presenting as unilateral pulmonary artery thrombosis and right ventricular failure

“…Newborns with ductal thrombosis have been reported to present with initial clinical stability followed by the onset of respiratory distress, need for increased ventilatory support, and progressive signs of right ventricular failure. [2][3][4] Risk factors for in utero thrombus development in this case include maternal diabetes and familial thrombophilia. 5 Prior reports have detailed extension of fetal ductal thrombus into the pulmonary arteries, but to our knowledge this is the first reported case of extension and embolisation leading to obstructive lesions in both the pulmonary and systemic circulations.…”

Spontaneous thrombosis of the arterial duct in a newborn with alloimmune thrombocytopaenia

“…It is caused by immunoglobulin G class antibodies against platelet antigens present in the newborn with consequent platelet destruction. 1 Immune thrombocytopenia is linked to both bleeding and thrombosis. 2 Spontaneous thrombus of the arterial duct, on the other hand, is a rare condition and a potential cause of fatal thromboembolism.…”