Prenatal ultrasound diagnosis of neural tube defects in the era of intrauterine repair – Eleven years’ experiences

Huang, Yu-Sin; Lussier, Eric C.; Olisova, Ksenia; Chang, Yian; Ko, Hsuan; Chang, Tung-Yao

doi:10.1016/j.tjog.2021.01.006

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…In contrast to previous studies that showed a normal cranial and CNS anatomy, we could show that signs of AC II malformation may be present in fetuses with CD 39–41 . In our study, small HC, cerebellar diameter <fifth percentile and lemon sign were present on prenatal US.…”

Section: Discussioncontrasting

confidence: 99%

“…In contrast to previous studies that showed a normal cranial and CNS anatomy, we could show that signs of AC II malformation may be present in fetuses with CD. [39][40][41] In our study, small HC, cerebellar diameter <fifth percentile and lemon sign were present on prenatal US. Although more subtle findings of AC II malformation can be seen on prenatal MRI, the presence of intracranial findings in CD may also be associated with the specific type of closed lesion, the anatomic level, and the size of the lesion.…”

Section: Patientsupporting

confidence: 51%

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Prenatal diagnosis and postnatal outcome of closed spinal dysraphism

Bedei,

Krispin,

Sanz Cortes

et al. 2023

Prenatal Diagnosis

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ObjectiveTo evaluate the prenatal diagnosis of closed dysraphism (CD) and its correlation with postnatal findings and neonatal adverse outcomes.MethodsA retrospective cohort study including pregnancies diagsnosed with fetal CD by prenatal ultrasound (US) and magnetic resonance imaging (MRI) at a single tertiary center between September 2011 and July 2021.ResultsCD was diagnosed prenatally and confirmed postnatally in 12 fetuses. The mean gestational age of prenatal imaging was 24.2 weeks, in 17% the head circumference was ≤fifth percentile and in 25% the cerebellar diameter was ≤fifth percentile. US findings included banana sign in 17%, and lemon sign in 33%. On MRI, posterior fossa anomalies were seen in 33% of cases, with hindbrain herniation below the foramen magnum in two cases. Mean clivus‐supraocciput angle (CSA) was 74°. Additional anomalies outside the CNS were observed in 50%. Abnormal foot position was demonstrated prenatally in 17%. Neurogenic bladder was present in 90% of patients after birth.ConclusionArnold Chiari II malformation and impaired motor function can be present on prenatal imaging of fetuses with CD and may be associated with a specific type of CD. Prenatal distinction of CD can be challenging. Associated extra CNS anomalies are frequent and the rate of neurogenic urinary tract dysfunction is high.

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Section: Discussioncontrasting

confidence: 99%

Section: Patientsupporting

confidence: 51%

Prenatal diagnosis and postnatal outcome of closed spinal dysraphism

Bedei,

Krispin,

Sanz Cortes

et al. 2023

Prenatal Diagnosis

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“…19 The most common chromosomal anomalies observed in MMCs are trisomy 13, trisomy 18, triploidy. 12 As regard maternal Serum Alpha-Fetoprotein (MSAFP) screening tests results among the study population, the present study showed that number of patients with MSAFP ≥ 2.0 MoM in the study population was 50 (25%). Number of patients with MSAFP < 2.0 MoM in the study population was 150 (75%).…”

Section: Discussionmentioning

confidence: 62%

Comparative study between 1st and 2nd trimester screening for neural tube defects using US markers and maternal serum alpha fetoportein

Ahmed

Sabry

El-Azeem³

2022

ijhs

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Background; Neural tube defects, the commonest central nervous system congenital anomalies, are a heterogeneous group of malformations resulting from failure of normal neural tube closure. Aim and objectives; to assess the potential value of combined maternal serum alpha-fetoprotein and ultrasound markers at 11-13weeks of gestation in early screening for fetal neural tube defects in comparison to the standard second trimester screening of neural tube defects. Subjects and methods; This prospective study will be conducted at the Prenatal Diagnosis and Fetal Medicine Department – National Research Centre and Obstetrics and Gynecology Department in Kasr Al Ainy Teaching Hospital. Result; Number of patients with MSAFP ≥ 2.0 MoM in the study population was 50 (25%). Number of patients with MSAFP < 2.0 MoM in the study population was 150 (75%). Conclusion; Combined maternal serum alpha-fetoprotein and ultrasound markers at 11-13 weeks of gestation can be used as early screening for fetal neural tube defects as well as the standard second trimester screening of neural tube defects, the second trimester ultrasound is more sensitive than that of the first trimester for the diagnoses of neural tube defects.

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“…13 Routine investigations for neural tube defects (NTDs) can be made with ultrasound as the screening test for the disease. 14,15 A high maternal serum Alpha-fetoprotein correlates positively with the disease. 16 An MRI is also performed in case of an inconclusive ultrasound.…”

Section: Introductionmentioning

confidence: 99%

Examining folic acid intake: a cross-sectional study of pregnancy-related practices

Khan,

Saad,

Syed

et al. 2024

Int J Res Med Sci

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Background: Folic acid supplementation during the periconceptional period is critical in preventing neural tube defects (NTDs) in the developing fetus. In Pakistan, a profound lack of awareness is seen regarding preventable pregnancy-related illnesses and the consequential high maternal and fetal mortality and morbidity rates. However, data from the surveys in the region of Sindh lacks inquiries regarding the baseline characteristics of the surveyed participants. Therefore, this study endeavoured to address this gap. Methods: Between October 2022 and April 2023, a cross-sectional study was conducted at two major tertiary care hospitals in Hyderabad and Jamshoro, Pakistan. A total of 374 participants, chosen by non-probability consecutive sampling, comprised the sample size. The association of demographic variables and knowledge, attitude, and practice of consumption of folic acid during pregnancy was determined using the χ2 test. A p value of less than 0.5 was considered statistically significant. Results: The mean age of the participants was 26.4±5.7 years. A total of 199 (53.20%) participants were literate, compared to 175 (46.79%) participants who were illiterate. Literate women fared better than illiterate women in all the metrics with a p-value of <0.001 and a Pearson correlation coefficient (r) of >0.7. Moreover, folic acid was consumed by only 38% of pregnant women during the periconceptional period. Conclusions: A substantial lack of knowledge regarding folic acid was found in the surveyed sample, significantly more marked in the illiterate faction. Additionally, the practice was rather unsatisfactory. However, the attitude remained encouraging.

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Prenatal ultrasound diagnosis of neural tube defects in the era of intrauterine repair – Eleven years’ experiences

Cited by 5 publications

References 30 publications

Prenatal diagnosis and postnatal outcome of closed spinal dysraphism

Prenatal diagnosis and postnatal outcome of closed spinal dysraphism

Comparative study between 1st and 2nd trimester screening for neural tube defects using US markers and maternal serum alpha fetoportein

Examining folic acid intake: a cross-sectional study of pregnancy-related practices

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