Prenatal vitamin D levels and child wheeze and asthma

Adams, Sarah J.; Adgent, Margaret A.; Gebretsadik, Tebeb; Hartman, Terryl J.; Vereen, Shanda; Ortiz, Christina; Tylavsky, Frances A.; Carroll, Kecia N.

doi:10.1080/14767058.2019.1607286

Cited by 16 publications

(6 citation statements)

References 47 publications

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“…Some studies have investigated the effect of VD supplementation on the mother with asthmatic history during pregnancy. It seems that sufficient serum 25(OH)D can reduce the risk of asthma in offspring born to asthmatic mothers [60]. Except that, COPD reveals no impact of VD on known molecular pathways.…”

Section: Discussionmentioning

confidence: 97%

Efficacy of vitamin D supplementation on COPD and asthma control: A systematic review and meta-analysis

Wang

Chen

et al. 2022

J Glob Health

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BackgroundThe role of vitamin D (VD) in the management of chronic obstructive pulmonary disease (COPD) and asthma remains largely undetermined. In the present meta-analysis, we aimed to comprehensively investigate the efficacy of VD in the treatment of COPD and asthma according to the latest update. MethodsThe PubMed, Embase, and Cochrane Library databases were searched from their inception to June 2, 2022. Randomized controlled trials (RCTs) comparing the efficacy of VD with placebo against COPD or asthma were included.Results A total of 11 RCTs consisting of 1183 COPD patients and 19 RCTs consisting of 2025 asthmatic patients were finally included. As for pulmonary function, FEV1/FVC was not changed significantly, while FEV1% was improved in the VD group. In the asthma subgroup, FEV1% was not changed significantly, while FEV1/FVC was improved in the VD group. For the questionnaire and rating scale, the mMRC (modified Medical Research Council) dyspnoea scale score for COPD and ACT (Asthma Control Test) score for asthma were not significantly changed, while the SGRQ (St. George's Respiratory Questionnaire) score for COPD was improved in the VD group. For inflammation indicators, IL-6 and IL-10 were statistically equivalent between the VD and placebo groups, while IgE, IL-5, and IL-10 (baseline VD deficiency subgroup) were improved in the VD group. The exacerbation, length of hospital stays, and mortality were statistically equivalent between the two groups.Conclusions VD supplementation improved the indicators of asthma and COPD, especially in pulmonary function, SGRQ scores, IL-5, and IgE.Registration The protocol could be found at PROSPERO with the registration number of CRD42020218058. Chronic obstructive pulmonary disease (COPD) has the highest mortality rate among chronic respiratory diseases [1]. COPD patients often show incomplete reversibility of airflow obstruction caused by emphysema and chronic bronchitis. It can eventually develop into severe diseases, such as pulmonary heart disease and respiratory failure. Currently, there is no good way to prevent development of the disease. Similarly, asthma is another common chronic inflammatory disease that can start at a young age. Like COPD, asthma can also develop into chronic airway limitation because of uncontrolled inflammation [2]. Because inflammation is crucial in pathogenesis of asthma, inflammation control is primary goal of asthma control [3]. Drug therapy includes bronchodilators, glucocorticoids and some-PAPERS

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Section: Discussionmentioning

confidence: 97%

Efficacy of vitamin D supplementation on COPD and asthma control: A systematic review and meta-analysis

Wang

Chen

et al. 2022

J Glob Health

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“…It is clear that, Vitamin D supplementation during pregnancy affects asthma occurrence in children, but meta-analyses and studies show conflicting results. Multivariable logistic regression found the association between maternal level of 25(OH)D during the second trimester and wheeze or asthma events in 4–6 years old children [ 32 ]. A meta-analysis of 15 prospective studies enrolling total of 12 758 participants found a non-linear (U-shaped) relationship between maternal 25-hydroxy vitamin D levels and risk of childhood asthma [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between vitamin D and asthma from gestational to adulthood period: a meta-analysis of randomized clinical trials

Sobczak

Pawliczak

2023

BMC Pulm Med

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Background Despite numerous studies investigating vitamin D, its impact on asthma is still unknown. The aim of our meta-analysis is to analyze the vitamin D supplementation influence on asthma prevention and treatment ranging from gestational to adulthood period. Methods Fifteen randomized clinical trials were included after database search. Studies contained the analyzed endpoints: the number of asthma and wheezing occurrence in gestational and infantile periods, the change of childhood/adult asthma control test score and forced expiratory volume in one second (FEV1) in childhood and adulthood periods. Random effects model was used to calculate effect sizes. Results Supplementation by women during pregnancy period decreased the wheezing occurrence in their children by 23% (RR = 0.77; 95% CI [0.64; 0.92]; p < 0.0049, I2 = 0%); whereas had no effect on given asthma parameters during the infantile period. Moreover, vitamin D administration had negative effect on the FEV1 change in children (MD = -3.84; 95% CI [-7.68; -0.01]; p = 0.0497; I2 = 95%), but had positive effect on the change of ACT score in adults (MD = 1.80; 95% CI [0.12; 3.49]; p = 0.0359; I2 = 99%). Conclusions Our meta-analysis showed the varying results depending on patient's life period. It is important to further investigate the role of vitamin D supplementation in asthma management.

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“…However, experiencing structural inequities could influence the placenta transcriptome (39). Plasma 25(OH)D concentrations levels have been linked to socioeconomic advantages and higher diet quality in this cohort previously (28,40). Thus, measures of multiple facets related to socioeconomic status and structural inequities, including NDI, education, and health insurance type were identified as confounding variables.…”

Section: Differentially Expressed Gene Identificationmentioning

confidence: 93%

Associations Between Prenatal Vitamin D and Placental Gene Expression

Parenti,

Melough,

Lapehn

et al. 2024

Preprint

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Background: Vitamin D is a hormone regulating gene transcription. Prenatal vitamin D has been linked to immune and vascular function in the placenta, a key organ of pregnancy. To date, studies of vitamin D and placental gene expression have focused on a limited number of candidate genes. Transcriptome-wide RNA sequencing can provide a more complete representation of the placental effects of vitamin D. Objective: We investigated the association between prenatal vitamin D levels and placental gene expression in a large, prospective pregnancy cohort. Methods: Participants were recruited in Shelby County, Tennessee in the Conditions Affecting Neurocognitive Development and Learning in Early childhood (CANDLE) study. Vitamin D level (plasma total 25-hydroxyvitatmin D, [25(OH)D]) was measured at mid-pregnancy (16-28 weeks' gestation) and delivery. Placenta samples were collected at birth. RNA was isolated and sequenced. We identified differentially expressed genes (DEGs) using adjusted linear regression models. We also conducted weighted gene co-expression network analysis (WGCNA). Results: The median 25(OH)D of participants was 21.8 ng/mL at mid-pregnancy (N=774, IQR: 15.4-26.5 ng/mL) and 23.6 ng/mL at delivery (N=753, IQR: 16.8-29.1 ng/mL). Placental expression of 25 DEGs was associated with 25(OH)D at mid-pregnancy, but no DEG was associated with 25(OH)D at delivery. DEGs were related to energy metabolism, cytoskeletal function, and RNA transcription. Using WGCNA, we identified 2 gene modules whose expression was associated with 25(OH)D at mid-pregnancy and 1 module associated with 25(OH)D at delivery. These modules were enriched for genes related to mitochondrial and cytoskeletal function, and were regulated by transcription factors includingARNT2,BHLHE40,FOSL2,JUND, andNFKB1. Conclusions: Our results indicate that 25(OH)D during mid-pregnancy, but not at delivery, is associated with placental gene expression at birth. Future research is needed to investigate a potential role of vitamin D in programming placental mitochondrial metabolism, intracellular transport, and transcriptional regulation during pregnancy.

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Prenatal vitamin D levels and child wheeze and asthma

Cited by 16 publications

References 47 publications

Efficacy of vitamin D supplementation on COPD and asthma control: A systematic review and meta-analysis

Efficacy of vitamin D supplementation on COPD and asthma control: A systematic review and meta-analysis

Relationship between vitamin D and asthma from gestational to adulthood period: a meta-analysis of randomized clinical trials

Associations Between Prenatal Vitamin D and Placental Gene Expression

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