Prenatal vitamin D supplementation to prevent childhood asthma: 15-year results from the Vitamin D Antenatal Asthma Reduction Trial (VDAART)

Weiss, Scott T.; Mirzakhani, Hooman; Carey, Vincent J.; O’Connor, George T.; Zeiger, Robert S.; Bacharier, Leonard B.; Stokes, Jeffrey; Litonjua, Augusto A.

doi:10.1016/j.jaci.2023.10.003

Cited by 10 publications

(1 citation statement)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We analyzed data from participants in the VDAART clinical trial [39]. VDAART is a randomized controlled trial of Vitamin D supplementation during pregnancy to prevent asthma in offspring conducted in the United States (St. Louis, Boston, and San Diego; NCT00920621).…”

Section: Vdaart and Children's Characteristicsmentioning

confidence: 99%

Genotype-microbiome-metabolome associations in early childhood, and their link to BMI and childhood obesity

Aparicio,

Sun,

Gold

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

The influence of genotype on defining the human gut microbiome has been extensively studied, but definite conclusions have not yet been found. To fill this knowledge gap, we leverage data from children enrolled in the Vitamin D Antenatal Asthma Reduction Trial (VDAART) from 6 months to 8 years old. We focus on a pool of 12 genes previously found to be associated with the gut microbiome in independent studies, establishing a Bonferroni corrected significance level of p-value < 2.29 × 10−6. We identified significant associations between SNPs in the FHIT gene (known to be associated with obesity and type 2 diabetes) and obesity-related microbiome features, and the children’s BMI through their childhood. Based on these associations, we defined a set of SNPs of interest and a set of taxa of interest. Taking a multi-omics approach, we integrated plasma metabolome data into our analysis and found simultaneous associations among children’s BMI, the SNPs of interest, and the taxa of interest, involving amino acids, lipids, nucleotides, and xenobiotics. Using our association results, we constructed a quadripartite graph where each disjoint node set represents SNPs in the FHIT gene, microbial taxa, plasma metabolites, or BMI measurements. Network analysis led to the discovery of patterns that identify several genetic variants, microbial taxa and metabolites as new potential markers for obesity, type 2 diabetes, or insulin resistance risk.

show abstract

Section: Vdaart and Children's Characteristicsmentioning

confidence: 99%

Genotype-microbiome-metabolome associations in early childhood, and their link to BMI and childhood obesity

Aparicio,

Sun,

Gold

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Income effect of prenatal sunlight exposure: Empirical evidence from China

Wan,

Zhang,

2024

Health Economics

View full text Add to dashboard Cite

Despite a growing interest in the impacts of prenatal factors on adulthood quality of life, economists have not estimated the income effects of sunlight exposures by mothers during pregnancy. This paper estimates such effects using data from China General Social Survey and China National Meteorological Data Service Center. The results show that the income effects of prenatal sunlight exposure in the second trimester are significantly positive. The effects differ for individuals born in different months and the effects are larger for female employees, older employees, those born in rural areas, in the pre‐reform period, or whose mothers are less‐educated. Finally, we investigate the possible mechanisms via the human capital pathway, discovering that fetuses with longer sunlight exposure in the second trimester are healthier and do more exercises in adulthood. It is suggested that families, communities, policymakers should pay attention to prenatal sunlight exposure, especially for pregnant women in the developing world who are less educated or live in rural areas.

show abstract

Early-life risk factors which govern pro-allergic immunity

Ptaschinski,

Gibbs

2024

Semin Immunopathol

View full text Add to dashboard Cite

Allergic diseases affect up to 40% of the global population with a substantial rise in food allergies, in particular, over the past decades. For the majority of individuals with allergy fundamental programming of a pro-allergic immune system largely occurs in early childhood where it is crucially governed by prenatal genetic and environmental factors, including their interactions. These factors include several genetic aberrations, such as filaggrin loss-of-function mutations, early exposure to respiratory syncytial virus, and various chemicals such as plasticizers, as well as the influence of the gut microbiome and numerous lifestyle circumstances. The effects of such a wide range of factors on allergic responses to an array of potential allergens is complex and the severity of these responses in a clinical setting are subsequently not easy to predict at the present time. However, some parameters which condition a pro-allergic immune response, including severe anaphylaxis, are becoming clearer. This review summarises what we currently know, and don’t know, about the factors which influence developing pro-allergic immunity particularly during the early-life perinatal period.

show abstract

Prenatal vitamin D supplementation to prevent childhood asthma: 15-year results from the Vitamin D Antenatal Asthma Reduction Trial (VDAART)

Cited by 10 publications

References 62 publications

Genotype-microbiome-metabolome associations in early childhood, and their link to BMI and childhood obesity

Genotype-microbiome-metabolome associations in early childhood, and their link to BMI and childhood obesity

Income effect of prenatal sunlight exposure: Empirical evidence from China

Early-life risk factors which govern pro-allergic immunity

Contact Info

Product

Resources

About