Prenatal zinc reduces stress response in adult rat offspring exposed to lipopolysaccharide during gestation

Galvão, Marcella C.; Chaves-Kirsten, Gabriela P.; Queiroz‐Hazarbassanov, Nicolle; Carvalho, Virgínia Martins; Bernardi, Maria Martha; Kirsten, Thiago Berti

doi:10.1016/j.lfs.2014.10.019

Cited by 18 publications

(10 citation statements)

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“…Zinc and linoleic acid and their combination improved the neuronal loss in the midbrain caused by rotenone administration. The decreases in necrotic cells observed in the zinc treated group agrees with the studies of Galvão et al [ 15 ] who also observed a decrease in the number of necrotic cells in hippocampus as well as cortex of zinc supplemented group for both male and female pups, in a study investigating the effect of “Prenatal zinc in adult rat offspring exposed to lipopolysaccharide during gestation”. Linoleic acid effect on the midbrain corroborates with the studies of Beltz et al [ 3 ], who investigated the effect of Linoleic acid on hippocampal neurogenesis.…”

Section: Discussionsupporting

confidence: 89%

Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

et al. 2018

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BackgroundStudies have suggested the supplementation of Zinc and Linoleic acid in the management of neurodegenerative disorders but none has investigated the combined effects. Little is known about the neuroprotective effects of either Zinc or Linoleic acid or their combination against development of Parkinsonism. This study was designed to investigate the neuroprotective effects of Zinc and Linoleic acid in rotenone-induced Parkinsonism in rats.MethodsThirty-six young adult female rats weighing 100–150 g divided into six groups were used. Rats were induced with Parkinsonism by subcutaneous administration of rotenone (2.5 mg/kg) once a day for seven consecutive days. The rats received dimethyl sulfoxide (DMSO)/Olive oil or rotenone dissolved in DMSO/Olive oil. Groups III and IV received Zinc (30 mg/kg) or Linoleic acid (150 µl/kg) while group V received a combination of both, 2 weeks prior to rotenone injection. Groups II and VI served as negative (rotenone group) and positive (Levodopa groups) controls respectively. Oxidative stress levels were assessed by estimating Lipid peroxidation (MDA), total antioxidant capacity, Superoxide dismutase, reduced Glutathione (GSH), glutathione peroxidase and catalase in the midbrain. Histological examination was done to assess structural changes in the midbrain.ResultsThere was a significant prevention in lipid peroxidation and decrease in the antioxidant status in intervention-treated groups as compared to the rotenone treated group. In addition, histological examination revealed that Parkinsonian rat brains exhibited neuronal damage. Cell death and reduction in neuron size induced by rotenone was prevented by treatment with zinc, linoleic acid and their combination.ConclusionThese results suggest that zinc and linoleic acid and their combination showed significant neuroprotective activity most likely due to the antioxidant effect.

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Section: Discussionsupporting

confidence: 89%

Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

et al. 2018

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“…Given that maternal immune activation alters hypothalamic functions in rodent offspring (42,78,158), neurodevelopmentally acquired abnormalities in the hypothalamus may contribute to the emergence of a hyperphagic phenotype in offspring with prenatal infection (111,115). An alternative (but not mutually exclusive) mechanism underlying such changes in food intake may be related to changes in the mesocorticolimbic dopamine system.…”

Section: Do Neurodevelopmental Deficits Contribute To Peripheral Abnomentioning

confidence: 99%

Long-term pathological consequences of prenatal infection: beyond brain disorders

Labouesse

Langhans

Meyer

2015

American Journal of Physiology-Regulatory, Integrative and Comp

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“…The rat social repertoire includes a prolonged period of juvenile play that may provide a preclinical model system to explore social impairments in more detail than is possible with other rodent models [ 13 , 14 ]. The potential of the rat ASD model has been established in prenatal toxicology studies with valproate [ 15 – 17 ], and is rapidly expanding to explore genetic susceptibility [ 18 , 19 ], underlying neurobiology [ 20 ] and potential therapeutic interventions for ASD [ 21 – 23 ]. Although there is increasing interest in utilizing the laboratory rat as a preclinical tool for ASD research, the behavioral outcome measures that are employed in rat ASD models are highly variable and there is a clear need to establish a robust and replicable rat behavioral testing battery that is relevant to core and associated symptoms of ASD [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders

Weir

Silverman

et al. 2016

PLoS ONE

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The laboratory rat is emerging as an attractive preclinical animal model of autism spectrum disorder (ASD), allowing investigators to explore genetic, environmental and pharmacological manipulations in a species exhibiting complex, reciprocal social behavior. The present study was carried out to compare two commonly used strains of laboratory rats, Sprague-Dawley (SD) and Long-Evans (LE), between the ages of postnatal day (PND) 26–56 using high-throughput behavioral phenotyping tools commonly used in mouse models of ASD that we have adapted for use in rats. We detected few differences between young SD and LE strains on standard assays of exploration, sensorimotor gating, anxiety, repetitive behaviors, and learning. Both SD and LE strains also demonstrated sociability in the 3-chamber social approach test as indexed by spending more time in the social chamber with a constrained age/strain/sex matched novel partner than in an identical chamber without a partner. Pronounced differences between the two strains were, however, detected when the rats were allowed to freely interact with a novel partner in the social dyad paradigm. The SD rats in this particular testing paradigm engaged in play more frequently and for longer durations than the LE rats at both juvenile and young adult developmental time points. Results from this study that are particularly relevant for developing preclinical ASD models in rats are threefold: (i) commonly utilized strains exhibit unique patterns of social interactions, including strain-specific play behaviors, (ii) the testing environment may profoundly influence the expression of strain-specific social behavior and (iii) simple, automated measures of sociability may not capture the complexities of rat social interactions.

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Prenatal zinc reduces stress response in adult rat offspring exposed to lipopolysaccharide during gestation

Cited by 18 publications

References 61 publications

Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

Long-term pathological consequences of prenatal infection: beyond brain disorders

Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders

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