Prenatally detected congenital medulloblastoma

Moradi, Behnaz; Hamidian, Yaser; Soltanghoraee, Haleh; Katouli, Fatemeh Shakki

doi:10.1002/jcu.23278

J of Clinical Ultrasound

2022

DOI: 10.1002/jcu.23278

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Prenatally detected congenital medulloblastoma

Behnaz Moradi

Yaser Hamidian²,

Haleh Soltanghoraee

et al.

Abstract: We describe a congenital cerebellar mass in a fetus at 30 weeks GA. The lesion is detected at the prenatal third‐trimester ultrasound, confirmed by fetal MRI, and determined as medulloblastoma in postmortem pathologic evaluation.

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2024

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Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoids

Willott,

Nicholson,

Xiao

et al. 2024

Preprint

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Faithful genetically engineered in vivo models of medulloblastoma (MB) are currently available only for some molecular subgroups, in keeping with recent studies showing the unique role of human-specific progenitors in the development of G3 and G4 MB subgroups. We generated human cerebellar organoids (CbO) from expanded potential stem cells (EPSC) and characterised in depth their epigenetic and transcriptomic profile. We show the presence of sub compartment-specific cerebellar lineages linked to MB formation, including populations expressing signature genes of G3 and G4 MB cells-of-origin in a 1 month-old CbO. Moreover, we demonstrate that CbO sustains MB cells proliferation and invasion in a 3D co-culture model (CbO-MB) while preserving their molecular identity, and that treatment of CbO-MB with anti-tumour compounds recapitulate the efficacy of in vivo drug testing in PDX models.

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Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoids

Willott,

Nicholson,

Xiao

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Prenatally detected congenital medulloblastoma

Abstract: We describe a congenital cerebellar mass in a fetus at 30 weeks GA. The lesion is detected at the prenatal third‐trimester ultrasound, confirmed by fetal MRI, and determined as medulloblastoma in postmortem pathologic evaluation.

Cited by 1 publication

References 5 publications

Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoids

Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoids

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