Prenatally detected umbilical cord tumor as a sign of diffuse neonatal hemangiomatosis

Schwickert, Axel C.; Seeger, K.; Rancourt, Rebecca C.; Henrich, Wolfgang

doi:10.1002/jcu.22689

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…248 Interestingly, prenatal sonographic detection of an umbilical cord hemangioma was recently reported as an early sign of diffuse neonatal hemangiomatosis (DNH) with the newborn later diagnosed with multiple hemangiomas in the liver, intestines, skin and brain. 257 Although hemangiomas may occur at any point throughout the entire length of the umbilical cord, the fetal and placental insertion sites (both fixed and often sonographically depicted) should be scanned in detail.…”

Section: Angioma/hemangiomamentioning

confidence: 99%

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Current Perspectives of Prenatal Sonography of Umbilical Cord Morphology

Sherer¹,

Al-Haddad²,

Cheng³

et al. 2021

IJWH

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The umbilical cord constitutes a continuation of the fetal cardiovascular system anatomically bridging between the placenta and the fetus. This structure, critical in human development, enables mobility of the developing fetus within the gestational sac in contrast to the placenta, which is anchored to the uterine wall. The umbilical cord is protected by unique, robust anatomical features, which include: length of the umbilical cord, Wharton's jelly, two umbilical arteries, coiling, and suspension in amniotic fluid. These features all contribute to protect and buffer this essential structure from potential detrimental twisting, shearing, torsion, and compression forces throughout gestation, and specifically during labor and delivery. The arterial components of the umbilical cord are further protected by the presence of Hyrtl's anastomosis between the two respective umbilical arteries. Abnormalities of the umbilical cord are uncommon yet include excessively long or short cords, hyper or hypocoiling, cysts, single umbilical artery, supernumerary vessels, rarely an absent umbilical cord, stricture, furcate and velamentous insertions (including vasa previa), umbilical vein and arterial thrombosis, umbilical artery aneurysm, hematomas, and tumors (including hemangioma angiomyxoma and teratoma). This commentary will address current perspectives of prenatal sonography of the umbilical cord, including structural anomalies and the potential impact of future imaging technologies.

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Section: Angioma/hemangiomamentioning

confidence: 99%

Section: Umbilical Cord Tumorsmentioning

confidence: 99%

Current Perspectives of Prenatal Sonography of Umbilical Cord Morphology

Sherer¹,

Al-Haddad²,

Cheng³

et al. 2021

IJWH

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show abstract

“… 7 In few cases, prenatal ultrasound with color Doppler may facilitate the early diagnosis of DNH and help through the early referral to specialized centers for appropriate treatment. 8 …”

Section: Discussionmentioning

confidence: 99%

Unusual Case of Diffuse Neonatal Hemangiomatosis Case Report and Literature Review

El Mansoury,

El Yousfi,

Halfi

et al. 2024

Global Pediatric Health

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Diffuse neonatal hemangiomatosis (DNH) is an infrequent condition characterized by the simultaneous occurrence of multiple cutaneous hemangiomas and the involvement of 3 or more organs. DNH is suspected when multiple hemangiomas are identified on the skin of the infant. Although it is benign in nature, DNH can lead to critical and life-threatening complications. Diagnosis primarily relies on clinical evaluation with a significant emphasis on imaging techniques. In this case report, we present an unusual pediatric case of diffuse infantile hemangioendothelioma, for which the investigative approach included ultrasound and CT scans. These imaging methods were instrumental in revealing the presence of lesions in the liver, thyroid, and brain, ultimately playing a pivotal role in making the diagnosis of DNH. A positive clinical and biological improvement was observed with corticosteroid treatment during a 3-month follow-up.

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“…Cases of umbilical cord angiomyxomas seen in association with cutaneous or visceral hemangiomas, i.e., port wine skin lesions, and single umbilical artery have been reported. Some cases of multiple lesions of the newborn were described with multiple hemangiomas in the liver, intestines, skin, and brain [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Large Angiomyxoma of the Umbilical Cord-Uncomplicated Rupture of Tumor Membranes at 32 Weeks of Gestation

2022

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Background: When a tumor of the umbilical cord is prenatally visualized, it is possible to propose the diagnosis depending on the sonographic appearance of the tumor. Angiomyxoma of the umbilical cord appears as a complex solid-cystic mass that is made of angiomatous component and myxoid stroma. When the tumor is diagnosed, serial ultrasound and doppler examinations are used to monitor the tumor’s size and the overall fetal well-being including doppler investigations and fetal growth. Angiomyxomas are not associated with fetal chromosomal pathologies. The cases of intrauterine rupture and fetal death was described in the literature. Case presentation: A 28 years-old pregnant woman was referred to our clinic for second opinion because of visualized umbilical cord tumor during second trimester ultrasound screening. The tumor gradually increased in size until 34th week of gestation, when the rupture of the cystic component was observed. The fetal doppler studies was normal during the course of pregnancy, we observed decreased AC and decreased estimated fetal weight. At the gestational age of the 37 weeks the labor was induced and heathy male infant was born. Conclusions: For the first time to our knowledge, we demonstrate the case of uncomplicated rupture of the cystic component of the angiomyxoma that lead to the possibility to manage the pregnancy conservatively without any compromise of the fetus.

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Prenatally detected umbilical cord tumor as a sign of diffuse neonatal hemangiomatosis

Cited by 6 publications

References 9 publications

Current Perspectives of Prenatal Sonography of Umbilical Cord Morphology

Current Perspectives of Prenatal Sonography of Umbilical Cord Morphology

Unusual Case of Diffuse Neonatal Hemangiomatosis Case Report and Literature Review

Large Angiomyxoma of the Umbilical Cord-Uncomplicated Rupture of Tumor Membranes at 32 Weeks of Gestation

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