Prenatally diagnosed cystic neuroblastoma

Hamada, Y.; Ikebukuro, Kazuya; Sato, Masahito; Tanano, Akihide; Kato, Yasunori; Takada, Kohei; Hioki, Koshiro

doi:10.1007/s003830050518

Cited by 39 publications

(20 citation statements)

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“…10 The absence of a large aberrant vessel does not rule out, however, the diagnosis of pulmonary sequestration, and color Doppler imaging cannot clearly distinguish between adrenal hemorrhage and hemorrhage occurring within a cystic NB. 7,[11][12][13][14] Computed tomography and MRI are highly contributory to the diagnosis of suprarenal masses when they show a systemic vessel of a sequestration. 10 Magnetic resonance imaging may show two different intensities within the mass, with debris-fluid levels suggesting intracystic hemorrhage, but again it is unable to distinguish between adrenal hemorrhage and hemorrhage occurring within a cystic LRNB.…”

Section: Discussionmentioning

confidence: 99%

Outcome of suprarenal localized masses diagnosed during the perinatal period

Sauvat

Sarnacki

Brisse

et al. 2002

Cancer

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BACKGROUNDThe growing use of abdominal ultrasonography during pregnancy and in the postnatal period is leading to the discovery of an increasing number of suprarenal masses. The optimal diagnosis and treatment of these masses has not yet been determined.METHODSThe authors reviewed the files of patients with suprarenal masses detected prenatally or during the first 3 months of life, between 1986 and 1999, in the pediatric surgery and oncology departments of Paris hospitals.RESULTSThirty masses were detected prenatally and 23 postnatally. In the latter group of patients, the diagnosis was based on ultrasound in 8 cases and on the palpation of a mass in 15 cases, 13 of which were neuroblastoma. At birth, the masses were cystic in 19 cases, solid in 17, and mixed in 13. Sensitivities of methyliodobenzylguanidine and urinary catecholamine assay were 70% and 52% respectively. Surgery was performed in 38 cases with a median age of 42 days. Histologic analysis showed 31 neuroblastomas, 1 adrenal hemorrhage, 2 necrotic masses, 1 bronchogenic cyst, and 3 sequestrations. All the patients were alive and disease free, at a follow‐up ranging from 3 months to 13 years.CONCLUSIONSIn this series, 58% of the suprarenal masses diagnosed perinatally were localized neuroblastoma with a favorable outcome. All other cases either regressed spontaneously or turned out to be benign lesion. Thus, the management of these masses must strike a compromise between aggressive treatment and a wait‐and‐see attitude. This requires appropriate initial assessment and a close follow‐up in a specialized center. Cancer 2002;94:2474–80. © 2002 American Cancer Society.DOI 10.1002/cncr.10502

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Section: Discussionmentioning

confidence: 99%

Outcome of suprarenal localized masses diagnosed during the perinatal period

Sauvat

Sarnacki

Brisse

et al. 2002

Cancer

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“…In 90-95% of the cases, only one side is affected, with a right-side predominance [13]. Among the perinatal adrenal tumours and tumours of the early life, neuroblastomas are the most common malignant solid tumours in infants !1 year old [14], but cystic neuroblastomas are rare [15]. Presently, there is no specific examination to establish an accurate diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Prenatally Detected Cystic Adrenal Mass Associated with Beckwith-Wiedemann Syndrome

et al. 2004

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We report a case of a right-sided cystic adrenal mass, detected after the 21st week of gestation, associated with fetal macrosomia. The diagnosis of Beckwith-Wiedemann syndrome was evoked. Prenatal sonography and magnetic resonance imaging did not allow establishing the origin of the suprarenal mass. The differential diagnosis of cystic neuroblastoma, pseudocystic adrenal haemorrhage, and adrenocortical macrocysts was discussed. A laparotomy was performed 2 weeks after birth due to the increasing size of the tumour and due to its possible malignant origin. Histological findings were haemorrhagic lesions without evidence of malignancy and adrenal cortical cytomegaly. The diagnosis of an adrenocortical macrocyst component of Beckwith-Wiedemann syndrome was established.

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“…Although we fully agree with the waitand-see strategy adopted postnatally, we would like to point out that prenatal adrenal hemorrhage might correspond to the more frequently reported cystic neuroblastoma [2,3] . Differentiation between these two clinical entities may be very difficult without pathological study and is rendered more complicated by the fact that urinary catecholamines are not raised in prenatal cystic neuroblastomas [2,3] .…”

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confidence: 89%