Preneoplastic changes in rabbit pancreatic duct cells produced by dimethylhydrazine

Elkort, Richard J.; Handler, Alfred H.; Mozden, Peter J.

doi:10.1002/ijc.2910160513

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…Phosphate-buffered saline was used as the DMH control and sesame oil was used for the B(a)P control. The effects of DMH have been reported previously [7,8]. The effects of B(a)P and MNU(T) will be described below.…”

Section: Carcinogenic Agentsmentioning

confidence: 84%

Carcinogen delivery into the pancreatic duct of rabbits by means of hollow fiber capsules

et al. 1977

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A technique is described for the delivery of various chemical agents chronically and in small doses directly into the duct of the rabbit pancreas. The feasibility of this technique is based on initial observations that implantation of a catheter delivery system in the pancreatic duct produces minimal interference with normal exocrine or endocrine pancreatic function while chronically delivering an encapsulated agent directly to the target tissues. A catheter permeation system has been designed which can be anchored in the main pancreatic duct of the New Zealand white rabbit without ligating the duct, and which will then continuously expose the ductal cells to chemical carcinogens over a 5-to 30-day period. Catheters have been successfully implanted in 177 rabbits. Examination of 37 control animals up to 182 weeks after implantation showed that, in the absence of ductal obstruction, neither the implantation procedure nor the presence of the catheter itself produced any permanent change in the morphologic structure of the pancreas. Benzo(a)pyrene produced hyperplasia, metaplasia, and adenosis, whereas methylnitrosourethane produced toxic pancreatitis and atrophy. The technique appears to be useful for evaluating the effect of carcinogens or other chemical agents when it is desirable to deliver a compound chronically and in small doses directly into the pancreatic juice.Anatomically, the pancreas is one of the most wellprotected organs in the mammalian abdomen. The disconcerting result of this natural advantage is that the pancreas is protected, not only from environmen-

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Section: Carcinogenic Agentsmentioning

confidence: 84%

Carcinogen delivery into the pancreatic duct of rabbits by means of hollow fiber capsules

et al. 1977

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“…Pancreatic cancer induction in rabbits was attempted by Elkort et al [87] in 1975 by dimethylhydrazine administration into the main pancreatic duct. The induced alterations were initially described as hyperplasia, dysplasia, and metaplasia of duct epithelium and progressed to periductal adenosis and adenoma formation between 34 and 48 weeks.…”

Section: Other Modelsmentioning

confidence: 99%

Experimental Animal Models in Pancreatic Carcinogenesis: Lessons for Human Pancreatic Cancer

Standop

Schneider

Ulrich

et al. 2001

Dig Dis

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The silent course of pancreatic cancer and its explosive fatal outcome have hindered studies of tumor histogenesis and the identification of early biochemical and genetic alterations that could help to diagnose the disease at a curable stage and develop therapeutic strategies. Experimental animal models provide important tools to assess risk factors, as well as preventive and therapeutic possibilities. Although several pancreatic cancer models presently exist, only models that closely resemble human tumors in morphological, clinical, and biological aspects present useful media for preclinical studies. Because an estimated 70% of human tumors are induced by carcinogens and because a significant association has been found between cigarette smoking and pancreatic cancer, chemically induced models are of particular value. Moreover, in such models the etiology, modifying factors, effects of diets, and naturally occurring products can be studied and early diagnostic, preventive, and therapeutic possibilities sought out. Many of the existing models are described in this review, and the advantages and shortcomings of each model and their clinical implications are discussed.

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Epithelial dysplasias in chronic pancreatitis

Volkholz

Stolte

Becker

1982

Virchows Arch. A Path. Anat. and Histol.

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The present 280 specimens of chronic pancreatitis were examined to determine the type and frequency of epithelial dysplasia of the duct system. The epitheilal dysplasias were divided into 3 degrees of severity according to cytological and histological criteria. Dysplasia was demonstrable in 40.1% of the 280 specimens. Of these 32.9% were classified as dysplasia grade I and 7.1% as dysplasia grade II. Dysplasia grade III did not occur. The epithelial proliferations were correlated with the topography, the stage of the scarring and the degree of obstruction of pancreatic secretion. An increase in dysplasia was evident in relation to the stage of the scarring and to the obstruction of secretory outflow. In correlation with the topography of the chronic pancreatitis there was the highest frequency of epithelial dysplasias in uniformly scarred glands (47.7%). Papillary and pseudopapillary hyperplasias with atypia were demonstrated in 17.9 vs. 4.5% of the cases with epithelial proliferations.

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Preneoplastic changes in rabbit pancreatic duct cells produced by dimethylhydrazine

Cited by 5 publications

References 2 publications

Carcinogen delivery into the pancreatic duct of rabbits by means of hollow fiber capsules

Carcinogen delivery into the pancreatic duct of rabbits by means of hollow fiber capsules

Experimental Animal Models in Pancreatic Carcinogenesis: Lessons for Human Pancreatic Cancer

Epithelial dysplasias in chronic pancreatitis

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