Prenylflavonoids counteract ovariectomy-induced disturbances in rats

Nowak, Beata; Matuszewska, Agnieszka; Popłoński, Jarosław; Nikodem, Anna; Filipiak, Jarosław; Tomanik, Magdalena; Dziewiszek, Wojciech; Danielewski, Maciej; Belowska-Bień, Kinga; Kłobucki, Marek; Sordon, Sandra; Jędrzejuk, Diana; Ceremuga, Ireneusz; Trocha, Małgorzata; Sozański, Tomasz; Piasecki, Tomasz; Bolanowski, Marek; Huszcza, Ewa; Szeląg, Adam

doi:10.1016/j.jff.2021.104742

Journal of Functional Foods

2021

DOI: 10.1016/j.jff.2021.104742

|View full text |Cite

Prenylflavonoids counteract ovariectomy-induced disturbances in rats

Beata Nowak

Agnieszka Matuszewska

Jarosław Popłoński

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Biotransformation of Xanthohumol by Entomopathogenic Filamentous Fungi

Łój,

Janeczko,

Bartmańska

et al. 2024

IJMS

View full text Add to dashboard Cite

Xanthohumol (1) is a major prenylated flavonoid in hops (Humulus lupulus L.) which exhibits a broad spectrum of health-promoting and therapeutic activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer effects. However, due to its lipophilic nature, it is poorly soluble in water and barely absorbed from the gastrointestinal tract, which greatly limits its therapeutic potential. One method of increasing the solubility of active compounds is their conjugation to polar molecules, such as sugars. Sugar moiety introduced into the flavonoid molecule significantly increases polarity, which results in better water solubility and often leads to greater bioavailability. Entomopathogenic fungi are well known for their ability to catalyze O-glycosylation reactions. Therefore, we investigated the ability of selected entomopathogenic filamentous fungi to biotransform xanthohumol (1). As a result of the experiments, one aglycone (2) and five glycosides (3–7) were obtained. The obtained (2″E)-4″-hydroxyxanthohumol 4′-O-β-D-(4‴-O-methyl)-glucopyranoside (5) has never been described in the literature so far. Interestingly, in addition to the expected glycosylation reactions, the tested fungi also catalyzed chalcone–flavanone cyclization reactions, which demonstrates chalcone isomerase-like activity, an enzyme typically found in plants. All these findings undoubtedly indicate that entomopathogenic filamentous fungi are still an underexploited pool of novel enzymes.

show abstract

Biotransformation of Xanthohumol by Entomopathogenic Filamentous Fungi

Łój,

Janeczko,

Bartmańska

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Prenylflavonoids counteract ovariectomy-induced disturbances in rats

Cited by 1 publication

References 38 publications

Biotransformation of Xanthohumol by Entomopathogenic Filamentous Fungi

Biotransformation of Xanthohumol by Entomopathogenic Filamentous Fungi

Contact Info

Product

Resources

About