Preoperative albumin to globulin ratio predicts survival in clear cell renal cell carcinoma patients

Chen, Zhe; Shao, Yingjie; Yao, Hongwei; Zhuang, Qianfeng; Wang, Kun; Zhou, Xing; Xu, Xianlin; He, Xiaozhou; Xu, Ran

doi:10.18632/oncotarget.15162

Cited by 53 publications

(71 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As mentioned, our analyses have shown that continuous PLR is an independent predictor of OS, but not CSS. However, in a study conducted by Chen et al, categorized PLR did not reach the level of statistical significance for either OS or CSS in multivariable analysis [40].…”

Section: Platelet-lymphocyte Ratiomentioning

confidence: 85%

Novel hematological biomarkers predict survival in renal cell carcinoma patients treated with nephrectomy

Rajwa¹,

Życzkowski²,

Paradysz³

et al. 2020

aoms

View full text Add to dashboard Cite

Introduction The association between novel blood-based inflammatory indices and patient survival has been reported with reference to various cancers. The aim of this study was to investigate the prognostic value of preoperative platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), derived neutrophil-lymphocyte ratio (dNLR) and lymphocyte-monocyte ratio (LMR) in patients with renal cell carcinoma (RCC) treated with nephrectomy. Material and methods From 2003 to 2012, 455 patients who underwent partial or radical nephrectomy for RCC were enrolled in the study. The study endpoints were overall survival (OS) and cancer-specific survival (CSS). Results The median follow-up was 70 months. Groups of patients with high levels of PLR, NLR and dNLR and a low level of LMR more often underwent radical nephrectomy, had a higher cancer stage in the TNM classification, and were more frequently diagnosed with tumor necrosis in histopathological examination. Both cancer-specific mortality and overall mortality were significantly higher in patients with high PLR, NLR and dNLR and low LMR. Multivariate analysis of CSS, adjusted for standard clinicopathological factors, identified only dNLR ( p = 0.006) as an independent prognostic factor. PLR ( p = 0.0002), dNLR ( p = 0.0003) and NLR ( p = 0.002), but not LMR ( p = 0.1), achieved prognostic significance in multivariable analysis regarding OS. Conclusions Only dNLR was an independent prognostic factor for CSS and OS. Nevertheless, our study indicates that all examined complete blood count-based biomarkers may be useful tools in managing RCC patients treated with a surgical approach.

show abstract

Section: Platelet-lymphocyte Ratiomentioning

confidence: 85%

Novel hematological biomarkers predict survival in renal cell carcinoma patients treated with nephrectomy

Rajwa¹,

Życzkowski²,

Paradysz³

et al. 2020

aoms

View full text Add to dashboard Cite

show abstract

“…Several studies have regarded dNLR as an inflammation marker that can reflect the severity of systematic inflammation in several cancers, such as non-small cell lung cancer, 11 colorectal cancer, 12 and breast cancer. 13 Serum albumin has been considered to have anti-inflammatory and possible immunomodulatory properties 14 ; therefore, if albumin synthesis was restricted by systematic inflammation, damage to the immune defense system of the patient could occur. 15 Moreover, previous ALB-dNLR score, Albumin-dNLR score; CRP, C-reactive protein; DAS28 score, 28-joint count Disease Activity Score; DMARDs, disease-modifying anti-rheumatic drugs; dNLR (Derived neutrophil to lymphocyte ratio), Neutrophil count to (Leukocyte-Neutrophil count) ratio; ESR, Erythrocyte sedimentation rate; NSAIDs, non-steroidal anti-inflammatory drugs; RF, rheumatoid factor.…”

Section: Discussionmentioning

confidence: 99%

The association between albumin‐dNLR score and disease activity in patients with rheumatoid arthritis

Chen

et al. 2018

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background Recently, clinical studies have described an association between albumin and the derived neutrophil to lymphocyte ratio (dNLR) with several diseases. This study was aimed to investigate the albumin‐dNLR (ALB‐dNLR) score in rheumatoid arthritis (RA) patients and assess its relationship with clinical and laboratory parameters of RA. Methods We retrospectively enrolled 127 RA patients, 155 osteoarthritis (OA) patients, and 155 healthy controls. The ALB‐dNLR score was based on serum albumin level, neutrophil count, and white cell count. The Spearman's rank test was used to measure the correlations between ALB‐dNLR score and disease activity as well as laboratory indexes. Results The ALB‐dNLR score was significantly higher in RA patients than in OA patients (P < 0.001) and in healthy controls (P < 0.001). The proportion of higher ALB‐dNLR score has been raised along with increased disease activity (P < 0.001). The Spearman's rank test showed that ALB‐dNLR score was positively associated with DAS28 score, CRP, ESR, IgA, and platelet count. Moreover, the receiver operating characteristic (ROC) curve showed that the area under the curve (AUC) of ALB‐dNLR was 0.693 (95% CI: 0.631‐0.755), which was higher than that of albumin (AUC: 0.625, 95% CI: 0.559‐0.692) and dNLR (AUC: 0.680, 95% CI: 0.617‐0.743) alone. Conclusions The results demonstrate that the ALB‐dNLR score increased in RA patients. The ALB‐dNLR score may be a useful marker to estimate the disease activity of RA patients.

show abstract

“…A preclinical study indicated that serum ALB could inhibit the growth of the breast cancer cell line MCF-7 by influencing autocrine growth regulatory factors. Studies also revealed that increased ALB and AGR were independently correlated with better survival in various cancers, including breast cancer (39)(40)(41)(42)(43)(44)(45), because ALB stabilizes DNA replication, increases the expression of major histocompatibility complex (MHC) II, and activates T cells (25,40,46).…”

Section: Discussionmentioning

confidence: 99%

Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients

et al. 2018

View full text Add to dashboard Cite

Transforming growth factor-β (TGF-β), interleukin-10 (IL-10), and forkhead box P3 (Foxp3) have important roles in breast cancer development. Previous studies confirmed a correlation between these immune molecules and tumor characteristics, but their association with nutritional status in breast cancer is largely unknown. We aimed to investigate the association between body mass index (BMI), hemoglobin, total protein, albumin, globulin (GLB), albumin/GLB ratio (AGR), pre-albumin, prognostic nutritional index, and TGF-β, IL-10, and Foxp3 mRNA expression in patients with breast cancer. Quantitative real-time PCR was used to detect the mRNA expression of TGF-β, IL-10, and Foxp3 in the peripheral blood of 107 patients with breast cancer and 21 healthy controls. We found that TGF-β mRNA levels were 2.6-fold, 3.2-fold, and 2.3-fold higher in patients with low BMI (<23), low AGR, and high GLB, respectively, than in their counterparts (P < 0.05). In addition, IL-10 mRNA expression levels in patients with normal BMI (<23) were 2.8-fold and 3.5-fold higher than in those who were overweight (23≤ BMI <25) and obese (BMI ≥ 25), respectively (P < 0.05). In addition, TGF-β, IL-10, and Foxp3 mRNA levels were significantly higher in patients with breast cancer than in healthy controls (P < 0.05). In summary, our results suggest that nutritional status, especially BMI, may strongly affect systematic immune function in patients with breast cancer. © 2018 IUBMB Life, 70(3):237-245, 2018.

show abstract

Preoperative albumin to globulin ratio predicts survival in clear cell renal cell carcinoma patients

Cited by 53 publications

References 30 publications

Novel hematological biomarkers predict survival in renal cell carcinoma patients treated with nephrectomy

Novel hematological biomarkers predict survival in renal cell carcinoma patients treated with nephrectomy

The association between albumin‐dNLR score and disease activity in patients with rheumatoid arthritis

Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients

Contact Info

Product

Resources

About